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ITGA8 (NM_003638) Human Untagged Clone

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SKU
SC303358
ITGA8 (untagged)-Human integrin, alpha 8 (ITGA8)
  $926.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol ITGA8
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>SC303358 representing NM_003638.
Blue=Insert sequence Red=Cloning site Green=Tag(s)

GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
ATGTCGCCCGGGGCCAGCCGCGGTCCCCGGGGAAGCCAGGCGCCGCTGATCGCGCCCCTCTGCTGCGCC
GCGGCCGCGCTGGGGATGTTGCTGTGGTCCCCCGCCTGTCAGGCGTTCAACCTGGACGTGGAAAAGCTC
ACAGTGTACAGCGGCCCCAAGGGCAGCTACTTCGGCTACGCCGTGGACTTCCACATACCCGACGCCCGC
ACAGCGAGTGTCTTGGTGGGGGCGCCCAAAGCCAACACCAGCCAGCCCGATATCGTGGAAGGGGGAGCC
GTCTATTACTGTCCTTGGCCCGCGGAGGGGTCTGCGCAGTGCAGGCAGATACCGTTTGACACCACCAAC
AACAGAAAGATCAGAGTTAATGGAACCAAAGAACCTATCGAGTTCAAATCCAATCAGTGGTTTGGAGCA
ACAGTGAAAGCTCACAAAGGAAAAGTTGTGGCCTGTGCTCCTTTATATCACTGGAGAACTCTTAAACCG
ACACCAGAAAAGGACCCAGTTGGCACCTGCTATGTAGCAATTCAGAACTTCAGCGCCTATGCCGAGTTC
TCTCCTTGCCGGAACAGCAATGCTGATCCGGAAGGCCAGGGTTACTGCCAAGCAGGATTTAGTCTGGAT
TTTTATAAGAATGGAGACCTTATTGTGGGAGGACCTGGGAGTTTCTACTGGCAAGGACAAGTGATCACT
GCCAGTGTTGCAGATATCATTGCAAATTACTCATTCAAGGATATCCTCAGGAAACTGGCAGGAGAAAAG
CAGACGGAAGTGGCTCCAGCTTCCTATGATGACAGTTACCTTGGATACTCAGTTGCTGCTGGGGAGTTT
ACTGGGGATTCTCAGCAAGAATTGGTTGCTGGAATTCCAAGAGGAGCACAGAATTTTGGATATGTTTCC
ATCATTAACTCTACGGATATGACGTTTATTCAGAATTTCACGGGAGAACAGATGGCATCTTATTTTGGA
TATACCGTTGTCGTATCAGATGTTAACAGTGATGGACTGGATGATGTCCTGGTTGGGGCACCTCTCTTT
ATGGAACGTGAATTTGAGAGCAACCCCAGAGAAGTAGGGCAAATCTACCTGTATTTGCAAGTGAGCTCT
CTCCTCTTCAGAGACCCCCAGATCCTCACTGGCACCGAGACGTTTGGGAGATTCGGTAGTGCTATGGCA
CACTTAGGAGACCTGAACCAAGATGGATACAATGACATTGCCATCGGAGTGCCTTTTGCAGGCAAGGAT
CAAAGAGGCAAAGTGCTCATTTATAATGGGAACAAAGATGGCTTAAACACCAAGCCTTCCCAAGTTCTG
CAAGGAGTGTGGGCCTCACATGCTGTCCCTTCCGGATTTGGCTTTACTTTAAGAGGAGATTCAGACATA
GACAAGAATGATTACCCAGATTTGATTGTGGGTGCATTTGGAACAGGAAAAGTCGCTGTTTACAGAGCA
AGACCGGTTGTGACTGTAGATGCCCAGCTTCTGCTGCACCCAATGATTATCAATCTTGAAAATAAAACT
TGCCAGGTTCCAGACTCTATGACATCTGCTGCCTGCTTTTCTTTAAGAGTATGTGCATCTGTCACAGGC
CAGAGCATTGCAAACACAATAGTCTTGATGGCAGAGGTGCAATTAGATTCCCTGAAACAGAAAGGAGCT
ATTAAACGGACGCTCTTCCTTGATAACCATCAGGCTCATCGCGTCTTCCCTCTTGTGATAAAAAGGCAG
AAATCCCACCAGTGCCAGGATTTCATCGTTTACCTTCGAGATGAAACTGAATTCCGAGATAAATTATCT
CCAATCAACATTAGTTTGAATTACAGTTTGGACGAATCCACCTTTAAAGAAGGCCTGGAAGTGAAACCA
ATATTGAACTACTACAGAGAAAACATTGTTAGTGAACAGGCTCACATTCTGGTGGACTGTGGAGAAGAC
AATCTGTGTGTTCCTGACTTGAAGCTGTCGGCTAGACCAGATAAGCATCAGGTAATCATTGGAGATGAA
AATCACCTTATGCTCATAATAAATGCAAGAAATGAAGGGGAAGGAGCATATGAAGCTGAACTCTTTGTA
ATGATACCAGAAGAGGCAGATTATGTTGGAATCGAACGCAACAACAAGGGATTTCGACCACTGAGCTGT
GAGTACAAGATGGAAAATGTAACCAGGATGGTGGTGTGTGACCTTGGGAACCCTATGGTGTCTGGAACA
AATTATTCCCTGGGCCTCCGATTTGCAGTTCCACGTCTTGAGAAAACAAACATGAGCATTAACTTCGAT
CTCCAAATCAGAAGTTCCAACAAGGACAATCCAGACAGCAATTTTGTGAGCCTGCAAATCAACATCACT
GCTGTAGCGCAGGTGGAAATAAGAGGAGTGTCACACCCTCCGCAGATTGTTCTGCCCATTCATAACTGG
GAACCAGAAGAGGAGCCCCACAAAGAGGAGGAGGTTGGACCATTGGTGGAACATATTTATGAGCTGCAC
AATATTGGACCAAGTACCATCAGTGACACCATCCTGGAGGTGGGCTGGCCTTTCTCTGCCCGGGATGAA
TTTCTTCTCTATATTTTCCATATTCAAACTCTGGGACCTCTGCAGTGCCAACCAAATCCTAATATCAAT
CCACAGGATATAAAGCCTGCTGCCTCCCCAGAGGACACCCCTGAGCTCAGCGCCTTTTTGCGAAACTCT
ACTATTCCTCATCTTGTCAGGAAGAGGGATGTACATGTGGTCGAATTCCACAGACAGAGCCCTGCAAAA
ATACTGAATTGTACAAATATCGAGTGTTTACAAATCTCCTGTGCAGTGGGACGACTCGAAGGAGGAGAA
AGCGCAGTCCTGAAAGTCAGGTCACGATTATGGGCCCACACCTTCCTCCAGAGAAAAAATGATCCCTAT
GCTCTTGCATCCCTGGTGTCCTTTGAAGTTAAGAAGATGCCTTATACAGATCAGCCAGCAAAACTCCCA
GAAGGAAGCATAGCAATTAAGACATCAGTTATTTGGGCAACTCCGAATGTTTCCTTCTCAATCCCATTA
TGGGTAATAATACTAGCAATACTTCTTGGATTGTTGGTTCTCGCCATTTTAACCTTAGCTTTATGGAAG
TGTGGATTCTTTGACAGAGCCAGACCTCCTCAGGAGGACATGACCGACAGGGAACAGCTGACAAATGAC
AAGACCCCTGAGGCATGA
ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT
TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites SgfI-MluI |
ACCN NM_003638
Insert Size 3192 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_003638.2
RefSeq Size 6982 bp
RefSeq ORF 3192 bp
Locus ID 8516
UniProt ID P53708
Cytogenetics 10p13
Protein Families Druggable Genome, Transmembrane
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton
MW 117.4 kDa
Summary Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Apr 2014
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
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"NM_003638" in other vectors (4)
SKU Description Size Price
RC218936 ITGA8 (Myc-DDK-tagged)-Human integrin, alpha 8 (ITGA8) 10 ug
$925.00
RC218936L3 Lenti ORF clone of Human integrin, alpha 8 (ITGA8), Myc-DDK-tagged 10 ug
$1,225.00
RC218936L4 Lenti ORF clone of Human integrin, alpha 8 (ITGA8), mGFP tagged 10 ug
$1,225.00
RG218936 ITGA8 (tGFP-tagged) - Human integrin, alpha 8 (ITGA8) 10 ug
$1,125.00

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