SGLT2 (SLC5A2) (NM_003041) Human Untagged Clone
SKU
SC303267
SLC5A2 (untagged)-Human solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2)
$616.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | SGLT2 |
| Synonyms | SGLT2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_003041 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_003041.2, NP_003032.1 |
| RefSeq Size | 2271 bp |
| RefSeq ORF | 2019 bp |
| Locus ID | 6524 |
| UniProt ID | P31639 |
| Cytogenetics | 16p11.2 |
| Protein Families | Transmembrane |
| Summary | This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. provided by RefSeq, Feb 2015 Transcript Variant: This variant (1) is the longer, protein-coding transcript. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_003041" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC224822 | SLC5A2 (Myc-DDK-tagged)-Human solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2) | 10 ug |
$615.00
|
|
| RC224822L1 | Lenti ORF clone of Human solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2), Myc-DDK-tagged | 10 ug |
$915.00
|
|
| RC224822L2 | Lenti ORF clone of Human solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2), mGFP tagged | 10 ug |
$915.00
|
|
| RC224822L3 | Lenti ORF clone of Human solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2), Myc-DDK-tagged | 10 ug |
$915.00
|
|
| RC224822L4 | Lenti ORF clone of Human solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2), mGFP tagged | 10 ug |
$915.00
|
|
| RG224822 | SLC5A2 (tGFP-tagged) - Human solute carrier family 5 (sodium/glucose cotransporter), member 2 (SLC5A2) | 10 ug |
$789.00
$815.00
|
|
Citations
The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties
Guo, Hu, DeOrazio et al
Bioorg. Med. Chem. (2014) 22 (13), 3414-22 DOI: 10.1016/j.bmc.2014.04.036
Guo, Hu, DeOrazio et al
Bioorg. Med. Chem. (2014) 22 (13), 3414-22 DOI: 10.1016/j.bmc.2014.04.036
Cited by 43
AI Summary: OriGene Technologies supplied the synthesized cDNAs for human SGLT1 (SLC5A1, NM_000343.1) and SGLT2 (SLC5A2, NM_003041.2), which were essential for generating the cell lines used to evaluate the potency and selectivity of the novel SGLT2 inhibitors described in the study.
Snippet: The cDNAs for the human genes of SGLT1 (SLC5A1—solute carrier family 5 sodium/glucose co-transporter member 1;Accession #NM_000343.1) or SGLT2 (SLC5A2—member 2;Accession #NM_003041.2) were synthesized (OriGene Technologies, Inc.) and sub-cloned into the mammalian expression vector, pcDNA3.1 (Invitrogen Corp., Carlsbad, CA) using standard molecular biology techniques. CHO-K1 cells transfected with pcDNA3.1 (Invitrogen Corp., Carlsbad, CA) containing either the full-length hSGLT1 or hSGLT2 using Lipofectamine 2000 (Invitrogen Corp., Carlsbad, CA) were selected for stable incorporation of the construct by resistance to the selective pressure of Geneticin
Showing 1-1 of 1 papers.
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