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CES2 (NM_003869) Human Untagged Clone

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SKU
SC128182
CES2 (untagged)-Human carboxylesterase 2 (CES2), transcript variant 1
  $581.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol CES2
Synonyms CE-2; CES2A1; iCE; PCE-2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC128182 sequence for NM_003869 edited (data generated by NextGen Sequencing)
ATGACTGCTCAGTCCCGCTCTCCTACCACACCCACCTTTCCCGGCCCAAGCCAGCGCACC
CCGCTGACTCCCTGCCCAGTCCAAACTCCAAGGCTGGGCAAGGCACTGATCCACTGCTGG
ACAGACCCGGGGCAGCCTCTGGGTGAACAGCAGCGTGTCCGCCGGCAGCGAACCGAGACC
AGCGAGCCGACCATGCGGCTGCACAGACTTCGTGCGCGGCTGAGCGCGGTGGCCTGTGGG
CTTCTGCTGCTTCTTGTCCGGGGCCAGGGCCAGGACTCAGCCAGTCCCATCCGGACCACA
CACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAA
ACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCT
GAGCCCCCTGAATCTTGGAGTGGTGTGAGGGATGGAACCACCCATCCGGCCATGTGTCTA
CAGGACCTCACCGCAGTGGAGTCAGAGTTTCTTAGCCAGTTCAACATGACCTTCCCTTCC
GACTCCATGTCTGAGGACTGCCTGTACCTCAGCATCTACACGCCGGCCCATAGCCATGAA
GGCTCTAACCTGCCGGTGATGGTGTGGATCCACGGTGGTGCGCTTGTTTTTGGCATGGCT
TCCTTGTATGATGGTTCCATGCTGGCTGCCTTGGAGAACGTGGTGGTGGTCATCATCCAG
TACCGCCTGGGTGTCCTGGGCTTCTTCAGCACTGGAGACAAGCACGCAACCGGCAACTGG
GGCTACCTGGACCAAGTGGCTGCACTACGCTGGGTCCAGCAGAATATCGCCCACTTTGGA
GGCAACCCTGACCGTGTCACCATTTTTGGCGAGTCTGCGGGTGGCACGAGTGTGTCTTCG
CTTGTTGTGTCCCCCATATCCCAAGGACTCTTCCACGGAGCCATCATGGAGAGTGGCGTG
GCCCTCCTGCCCGGCCTCATTGCCAGCTCAGCTGATGTCATCTCCACGGTGGTGGCCAAC
CTGTCTGCCTGTGACCAAGTTGACTCTGAGGCCCTGGTGGGCTGCCTGCGGGGCAAGAGT
AAAGAGGAGATTCTTGCAATTAACAAGCCTTTCAAGATGATCCCCGGAGTGGTGGATGGG
GTCTTCCTGCCCAGGCACCCCCAGGAGCTGCTGGCCTCTGCCGACTTTCAGCCTGTCCCT
AGCATTGTTGGTGTCAACAACAATGAATTCGGCTGGCTCATCCCCAAGGTCATGAGGATC
TATGATACCCAGAAGGAAATGGACAGAGAGGCCTCCCAGGCTGCTCTGCAGAAAATGTTA
ACGCTGCTGATGTTGCCTCCTACATTTGGTGACCTGCTGAGGGAGGAGTACATTGGGGAC
AATGGGGATCCCCAGACCCTCCAAGCGCAGTTCCAGGAGATGATGGCGGACTCCATGTTT
GTGATCCCTGCACTCCAAGTAGCACATTTTCAGTGTTCCCGGGCCCCTGTGTACTTCTAC
GAGTTCCAGCATCAGCCCAGCTGGCTCAAGAACATCAGGCCACCGCACATGAAGGCAGAC
CATGGTGATGAGCTTCCTTTTGTTTTCAGAAGTTTCTTTGGGGGCAACTACATTAAATTC
ACTGAGGAAGAGGAGCAGCTAAGCAGGAAGATGATGAAGTACTGGGCCAACTTTGCGAGA
AATGGGAACCCCAATGGCGAGGGTCTGCCACACTGGCCGCTGTTCGACCAGGAGGAGCAA
TACCTGCAGCTGAACCTACAGCCTGCGGTGGGCCGGGCTCTGAAGGCCCACAGGCTCCAG
TTCTGGAAGAAGGCGCTGCCCCAAAAGATCCAGGAGCTCGAGGAGCCTGAAGAGAGACAC
ACAGAGCTGTAG

Clone variation with respect to NM_003869.5
5' Read Nucleotide Sequence
>OriGene 5' read for NM_003869 unedited
TTTAGGCTCCATTTGTATACCACTTACTATAGGCGGCCGCGNATTCANATCCACAAGTTT
GTACAAAAAAGCAGCTTGTAAAACGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAG
GCCTGGGTGGCGAATTCGGCACGAGGGTCGCGCGAGGGACACGCCGCGTTGTGGGTTCTC
GGCCTGAGGTGCGAGAGAAGCGGTGACCGCGGCCCTGGCTGCTCGGACCCGGGAACATGA
TGGTCGCTGGAGCAGAAGGCGCTGAGAAGGGACCACGGCGGCGCTGGGTCGTGCGAGCCA
GTAGCGGGCTGAAACGTAGAGGCCAGAACCAGGTCTCAGGGGGCACTAAAGGCGGTCGGA
GGTAATCCCCACACCGCTTCCTCCTGGAAGTCAGGCTGGCCGGGAGCTCCCGTATCCAGG
ACGGTTGGTCGCCTCTGGCCTGGCAGGGATCCTAGTGTCTCGGGACCTCCCGGTGACGCG
CCTGCCTCCCCTGCTGCACCATAGGCCCCGGGAGTACGGCGTCCCCCACAGCTTGAACCG
GCGGGGGCTCGTGAAATGTTGTGCAGGGGGATAATTGACCATGGCCGTGGTCTTCGCGGG
AGGTGAGGAAACTTGAAGCCACCCGTGAAAAGGGGGGCCCTCCTTTAGAAATGCCCGCGT
CACCTGTCCCTTTCAAAAAATGGCCGTGCCTTGATAGGGAGGGGACCGCGGGAAACCTTT
ACCCCCCTCTACTTTTAAAGAAAATTAGGGCCCCCTTAAGGGGTAACCCCGGGAAACTGG
GTCCTCTGCAACAGAAGGGGGAATCTTCCCAATTTGAGGGGGGCCGAAACCTCCTTTCCT
GCCTTTTGTAAGAGGGGTTCTCTTTCCCCCAATCAAATGCTTCTCCCACTTTCTCCCTTT
CGGGGTGATTCCCTAACCCG
Restriction Sites Please inquire |
ACCN NM_003869
Insert Size 3200 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_003869.4, NP_003860.2
RefSeq Size 3957 bp
RefSeq ORF 1872 bp
Locus ID 8824
UniProt ID O00748
Cytogenetics 16q22.1
Domains COesterase
Protein Families Druggable Genome
Protein Pathways Drug metabolism - other enzymes
Summary This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.provided by RefSeq, Oct 2010
Transcript Variant: This variant (1) encodes the longest isoform (1) and contains a longer 5' UTR than some of the other variants. This variant represent use of an alternate promote that is used in some tissues, and uses a downstream start codon. The upstream start codon is not well conserved. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data.
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Documents
Resources
"NM_003869" in other vectors (6)
SKU Description Size Price
RC203009 CES2 (Myc-DDK-tagged)-Human carboxylesterase 2 (CES2), transcript variant 1 10 ug
$580.00
RC203009L1 Lenti ORF clone of Human carboxylesterase 2 (CES2), transcript variant 1, Myc-DDK-tagged 10 ug
$880.00
RC203009L2 Lenti ORF clone of Human carboxylesterase 2 (CES2), transcript variant 1, mGFP tagged 10 ug
$880.00
RC203009L3 Lenti ORF clone of Human carboxylesterase 2 (CES2), transcript variant 1, Myc-DDK-tagged 10 ug
$880.00
RC203009L4 Lenti ORF clone of Human carboxylesterase 2 (CES2), transcript variant 1, mGFP tagged 10 ug
$880.00
RG203009 CES2 (tGFP-tagged) - Human carboxylesterase 2 (CES2), transcript variant 1 10 ug
$489.00 $780.00

file-alt Citations

Metabolism and Pharmacokinetics of the Anti-HCV Nucleotide Prodrug GS-6620
Murakami, Wang, Babusis et al
Antimicrob. Agents Chemother. (2014)
AI Summary: OriGene Technologies' expression plasmids (pcDNA3.1-CatA, pcDNA3.1-Ces1, pcDNA3.1-Ces2, pcDNA3.1-Hint2, and pcDNA3.1-Hint3) were used to study the roles of specific enzymes in the metabolism and activation of the anti-HCV prodrug GS-6620.
Snippet: with 0.5 µg pcDNA3.1 or pcDNA3.1-CatA, pcDNA3.1-Ces1, pcDNA3.1-Ces2, 128 pcDNA3.1-Hint2 or pcDNA3.1-Hint3 (Origene Technologies;Rockville, MD) 129 expression plasmids using 1 µL/well TransIT -293 Transfection Reagent (Mirus, 130 Madison, WI). ... Cite SaveSaving
Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity
Wong, Cheng, Xie et al
J. Pharmacol. Exp. Ther. (2012) 340 (2), 422-32 DOI: 10.1124/jpet.111.188508
Cited by 44
AI Summary: OriGene contributed CES1 and CES2 expression plasmids, which were used to study how these human carboxylesterases metabolize phospho-NSAIDs and affect their anticancer activity.
Snippet: NM_003869.4) expression plasmids were obtained from Origene (Rockville, MD). ... cells toward phospho-NSAIDs;whereas high CES2 expression in HepG2 cells was consistent with significant hydrolysis of phospho-aspirins (MDC-46 and MDC-22) that are good substrates of
Showing 1-2 of 2 papers.
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