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VR1 (TRPV1) (NM_080704) Human Untagged Clone

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SKU
SC128105
TRPV1 (untagged)-Human transient receptor potential cation channel, subfamily V, member 1 (TRPV1), transcript variant 1
  $769.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol VR1
Synonyms VR1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC128105 sequence for NM_080704 edited (data generated by NextGen Sequencing)
ATGAAGAAATGGAGCAGCACAGACTTGGGGGCAGCTGCGGACCCACTCCAAAAGGACACC
TGCCCAGACCCCCTGGATGGAGACCCTAACTCCAGGCCACCTCCAGCCAAGCCCCAGCTC
TCCACGGCCAAGAGCCGCACCCGGCTCTTTGGGAAGGGTGACTCGGAGGAGGCTTTCCCA
GTGGATTGCCCTCACGAGGAAGGTGAGCTGGACTCCTGCCCGACCATCACAGTCAGCCCT
GTTATCACCATCCAGAGGCCAGGAGACGGCCCCACCGGTGCCAGGCTGCTGTCCCAGGAC
TCTGTCGCCGCCAGCACCGAGAAGACCCTCAGGCTCTATGATCGCAGGAGTATCTTTGAA
GCCGTTGCTCAGAATAACTGCCAGGATCTGGAGAGCCTGCTGCTCTTCCTGCAGAAGAGC
AAGAAGCACCTCACAGACAACGAGTTCAAAGACCCTGAGACAGGGAAGACCTGTCTGCTG
AAAGCCATGCTCAACCTGCACGACGGACAGAACACCACCATCCCCCTGCTCCTGGAGATC
GCGCGGCAAACGGACAGCCTGAAGGAGCTTGTCAACGCCAGCTACACGGACAGCTACTAC
AAGGGCCAGACAGCACTGCACATCGCCATCGAGAGACGCAACATGGCCCTGGTGACCCTC
CTGGTGGAGAACGGAGCAGACGTCCAGGCTGCGGCCCATGGGGACTTCTTTAAGAAAACC
AAAGGGCGGCCTGGATTCTACTTCGGTGAACTGCCCCTGTCCCTGGCCGCGTGCACCAAC
CAGCTGGGCATCGTGAAGTTCCTGCTGCAGAACTCCTGGCAGACGGCCGACATCAGCGCC
AGGGACTCGGTGGGCAACACGGTGCTGCACGCCCTGGTGGAGGTGGCCGACAACACGGCC
GACAACACGAAGTTTGTGACGAGCATGTACAATGAGATTCTGATGCTGGGGGCCAAACTG
CACCCGACGCTGAAGCTGGAGGAGCTCACCAACAAGAAGGGAATGACGCCGCTGGCTCTG
GCAGCTGGGACCGGGAAGATCGGGGTCTTGGCCTATATTCTCCAGCGGGAGATCCAGGAG
CCCGAGTGCAGGCACCTGTCCAGGAAGTTCACCGAGTGGGCCTACGGGCCCGTGCACTCC
TCGCTGTACGACCTGTCCTGCATCGACACCTGCGAGAAGAACTCGGTGCTGGAGGTGATC
GCCTACAGCAGCAGCGAGACCCCTAATCGCCACGACATGCTCTTGGTGGAGCCGCTGAAC
CGACTCCTGCAGGACAAGTGGGACAGATTCGTCAAGCGCATCTTCTACTTCAACTTCCTG
GTCTACTGCCTGTACATGATCATCTTCACCATGGCTGCCTACTACAGGCCCGTGGATGGC
TTGCCTCCCTTTAAGATGGAAAAAATTGGAGACTATTTCCGAGTTACTGGAGAGATCCTG
TCTGTGTTAGGAGGAGTCTACTTCTTTTTCCGAGGGATTCAGTATTTCCTGCAGAGGCGG
CCGTCGATGAAGACCCTGTTTGTGGACAGCTACAGTGAGATGCTTTTCTTTCTGCAGTCA
CTGTTCATGCTGGCCACCGTGGTGCTGTACTTCAGCCACCTCAAGGAGTATGTGGCTTCC
ATGGTATTCTCCCTGGCCTTGGGCTGGACCAACATGCTCTACTACACCCGCGGTTTCCAG
CAGATGGGCATCTATGCCGTCATGATAGAGAAGATGATCCTGAGAGACCTGTGCCGTTTC
ATGTTTGTCTACGTCGTCTTCTTGTTCGGGTTTTCCACAGCGGTGGTGACGCTGATTGAA
GACGGGAAGAATGACTCCCTGCCGTCTGAGTCCACGTCGCACAGGTGGCGGGGGCCTGCC
TGCAGGCCCCCCGATAGCTCCTACAACAGCCTGTACTCCACCTGCCTGGAGCTGTTCAAG
TTCACCATCGGCATGGGCGACCTGGAGTTCACTGAGAACTATGACTTCAAGGCTGTCTTC
ATCATCCTGCTGCTGGCCTATGTAATTCTCACCTACATCCTCCTGCTCAACATGCTCATC
GCCCTCATGGGTGAGACTGTCAACAAGATCGCACAGGAGAGCAAGAACATCTGGAAGCTG
CAGAGAGCCATCACCATCCTGGACACGGAGAAGAGCTTCCTTAAGTGCATGAGGAAGGCC
TTCCGCTCAGGCAAGCTGCTGCAGGTGGGGTACACACCTGATGGCAAGGACGACTACCGG
TGGTGCTTCAGGGTGGACGAGGTGAACTGGACCACCTGGAACACCAACGTGGGCATCATC
AACGAAGACCCGGGCAACTGTGAGGGCGTCAAGCGCACCCTGAGCTTCTCCCTGCGGTCA
AGCAGAGTTTCAGGCAGACACTGGAAGAACTTTGCCCTGGTCCCCCTTTTAAGAGAGGCA
AGTGCTCGAGATAGGCAGTCTGCTCAGCCCGAGGAAGTTTATCTGCGACAGTTTTCAGGG
TCTCTGAAGCCAGAGGACGCTGAGGTCTTCAAGAGTCCTGCCGCTTCCGGGGAGAAGTGA

Clone variation with respect to NM_080704.3
180 g=>a;1406 c=>t;1753 a=>g
5' Read Nucleotide Sequence
>OriGene 5' read for NM_080704 unedited
NGGGGGTTCGAATTTGTATACGACTCATATAGGCGGCCGCGATTGATCCGCAGGATGAAG
AAATGGAGCAGCACAGACTTGGGGGCAGCTGCGGACCCACTCCAAAGGACACCTGCCCAG
ACCCCCTGGATGGAGACCCTAACTCCAGGCCACCTCCAGCCAAGCCCCAGCTCTCCACGG
CCAAGAGCCGCACCCGGCTCTTTGGGAAGGGTGACTCGGAGGAGGCTTTCCCAGTGGATT
GCCCTCACGAGGAAGGTGAGCTGGACTCCTGCCCGACCATCACAGTCAGCCCTGTTATCA
CCATCCAGAGGCCAGGAGACGGCCCCACCGGTGCCAGGCTGCTGTCCCAGGACTCTGTCG
CCGCCAGCACCGAGAAGACCCTCAGGCTCTATGATCGCAGGAGTATCTTTGAAGCCGTTG
CTCAGAATAACTGCCAGGATCTGGAGAGCCTGCTGCTCTTCCTGCAGAAGAGCAAGAAGC
ACCTCACAGACAACGAGTTCAAAGACCCTGAGACAGGGAAGACCTGTCTGCTGAAAGCCA
TGCTCAACCTGCACGACGGACAGAACACCACCATCCCCCTGCTCCTGGAGATCGCGCGGC
AAACGGACAGCCTGAAGGAGCTTGTCAACGCCAGCTACACGGACAGCTACTACAAGGGCC
AGACAGCACTGCACATCGCCATCGAGAGACGCAACATGGCCCTGGTGACCCTCCTGGTGG
AGAACGGAGCAGACGTCCAGGCTGCGGCCCATGGGGACTTCTTTAAGAAAACCAAAGGGC
GGCCTGGATTCTACTTCGGTGAACTGCCCCTGTCCCTGGCCGCGTGCACCAACCAGCTGG
GCATCGTGAAGTTCCTGCTGCAGAACTCCTGC
Restriction Sites Please inquire |
ACCN NM_080704
Insert Size 3900 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_080704.2, NP_542435.2
RefSeq Size 4163 bp
RefSeq ORF 2520 bp
Locus ID 7442
UniProt ID Q8NER1
Cytogenetics 17p13.2
Protein Families Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
Protein Pathways Neuroactive ligand-receptor interaction
Summary Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. provided by RefSeq, Jul 2008
Transcript Variant: This variant (1) contains a different segment in the 5' UTR, compared to variant 3. Variants 1-4 all encode the same protein.
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Documents
Resources
"NM_080704" in other vectors (6)
SKU Description Size Price
RC217653 TRPV1 (Myc-DDK-tagged)-Human transient receptor potential cation channel, subfamily V, member 1 (TRPV1), transcript variant 1 10 ug
$589.00 $768.00
RC217653L1 Lenti ORF clone of Human transient receptor potential cation channel, subfamily V, member 1 (TRPV1), transcript variant 1, Myc-DDK-tagged 10 ug
$1,068.00
RC217653L2 Lenti ORF clone of Human transient receptor potential cation channel, subfamily V, member 1 (TRPV1), transcript variant 1, mGFP tagged 10 ug
$1,068.00
RC217653L3 Lenti ORF clone of Human transient receptor potential cation channel, subfamily V, member 1 (TRPV1), transcript variant 1, Myc-DDK-tagged 10 ug
$1,068.00
RC217653L4 Lenti ORF clone of Human transient receptor potential cation channel, subfamily V, member 1 (TRPV1), transcript variant 1, mGFP tagged 10 ug
$1,068.00
RG217653 TRPV1 (tGFP-tagged) - Human transient receptor potential cation channel, subfamily V, member 1 (TRPV1), transcript variant 1 10 ug
$789.00 $968.00

file-alt Citations

Molecular signaling of synthetic cannabinoids: Comparison of CB1 receptor and TRPV1 channel activation
Andersen, Walsh
Eur J Pharmacol (2021) 907, 174301 DOI: 10.1016/j.ejphar.2021.174301
Cited by 14
AI Summary: In this study, OriGene products—specifically, the CB1 receptor cDNA (NM_016083) and TRPV1 channel cDNA (NM_080706)—were used to express these proteins in cells, enabling the authors to assess how different synthetic cannabinoids activate CB1 and TRPV1 channels.
FigureFigure
Molecular signaling of synthetic cannabinoids: Comparison of CB1 receptor and TRPV1 channel activation
Andersen, Walsh
European Journal of Pharmacology (2021) 907, 174301 DOI: 10.1016/j.ejphar.2021.174301
Cited by 14
AI Summary: In this study, OriGene's human TRPV1 channel cDNA (#SC128105) was used to transiently transfect HEK293T cells, enabling the researchers to assess the activation of TRPV1 channels by synthetic cannabinoids.
Snippet: HEK293T cells were cultured as above with the addition of 2 mM glutamine to the media and transiently transfected with the human TRPV1 channel (Origene cDNA #SC128105) or GFP using Lipofectamine 2000 (Invitrogen);HEK293T cells were cultured as above with the addition of 2 mM glutamine to the media and transiently transfected with the human TRPV1 channel (Origene cDNA #SC128105) or GFP using Lipofectamine 2000 (Invitrogen)
Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel
Long, Fatehi, Soni et al
J. Physiol. (Lond.) (2020)
AI Summary: OriGene contributed to this study by providing the human TRPV1 gene in the pCMV6 vector (OriGene, cat#: SC128105), which was used for transfection into HEK293T cells to investigate the effects of vitamin D on TRPV1 channel activity.
Snippet: with 5% CO2. The human TRPV1 gene in pCMV6 vector (Origene, cat#: SC128105 USA) was co-transfected with a GFP or mCherry vector into HEK293T cells for visual identification of transfected cells. Point mutations were
Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa
Moon, Kim, Son et al
PLoS ONE (2015) 10 (5), e0127060 DOI: 10.1371/journal.pone.0127060
Cited by 15
AI Summary: OriGene contributed to this study by providing the hTRPV1 clone (NCBI accession number: NG_029716.1), which was used for transient transfection experiments to assess the activity of compounds from Agastache rugosa on hTRPV1-expressing cells.
Snippet: The hTRPV1 used for transient transfection was cloned by OriGene (Rockville, MD, USA;NCBI accession number: NG_029716.1). The hTRPV1 construct was cloned into pEAK10 (Edge Biosystems, Gaithersburg, MD, USA) and the nucleotide sequence of the hTRPV1 ... Cite SaveSaving
FigureFigureFigure
Intracellular Long-Chain Acyl CoAs Activate TRPV1 Channels
Yu, Carter, Youssef et al
PLoS ONE (2014) 9 (5), e96597 DOI: 10.1371/journal.pone.0096597
Cited by 20
AI Summary: OriGene contributed to this study by providing the full-length human TRPV1 DNA construct, which was used for site-directed mutagenesis experiments to investigate TRPV1 channel regulation.
Snippet: and Felix ratio-metric software (Photon Technologies International, NJ, USA). Site-directed Mutagenesis. The full-length human TRPV1 DNA construct was purchased from OriGene (OriGene Technologies, Rockville, MD, US. Cite SaveSaving
FigureFigureFigure
Furanocoumarins are a Novel Class of Modulators for the TRPV1 Channel
Chen, Sun, Gianaris et al
J. Biol. Chem. (2014)
AI Summary: OriGene Technologies contributed to this study by providing the human TRPV1 cDNA clone (transcript variant 1, accession number NM_080704.2), which was essential for investigating how furanocoumarins modulate the TRPV1 channel.
Snippet: TRPV1 cDNA clone was purchased from OriGene Technologies (Rockville, MD;transcript variant 1). The accession number of the human TRPV1 cDNA is NM_080704.2. 4 μg TRPV1 and 0.25 μg pEYFP-C1 (Clontech Laboratories, Inc., Mountain View, CA) plasmids ... Cite SaveSaving
Showing 1-6 of 6 papers.
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