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IREB2 (NM_004136) Human Untagged Clone

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SKU
SC128101
IREB2 (untagged)-Human iron-responsive element binding protein 2 (IREB2)
  $883.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol IREB2
Synonyms ACO3; IRE-BP 2; IRE-BP2; IRP2; IRP2AD; NDCAMA
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC128101 sequence for NM_004136 edited (data generated by NextGen Sequencing)
ATGGACGCCCCAAAAGCAGGATACGCCTTTGAGTACCTTATTGAAACATTAAATGACAGT
TCACATAAGAAGTTCTTCGATGTATCTAAACTTGGCACCAAGTATGATGTTCTGCCTTAC
TCAATACGGGTCTTGTTGGAAGCTGCTGTACGAAATTGTGATGGCTTTTTAATGAAGAAG
GAAGATGTTATGAACATTTTAGACTGGAAAACCAAACAAAGCAATGTTGAAGTGCCCTTT
TTCCCTGCCCGTGTTCTTCTTCAAGATTTTACTGGAATACCAGCAATGGTGGATTTTGCT
GCTATGAGGGAGGCAGTGAAAACTCTTGGAGGTGATCCTGAGAAAGTCCATCCTGCTTGT
CCGACAGATCTTACAGTTGACCATTCTTTACAAATTGACTTCAGTAAATGTGCAATACAG
AATGCACCAAATCCTGGAGGTGGTGACCTGCAGAAAGCAGGAAAGCTCTCTCCACTTAAA
GTGCAGCCTAAGAAGCTTCCCTGCAGAGGCCAGACTACCTGCCGAGGATCTTGTGATTCT
GGAGAACTAGGCCGAAACTCAGGAACATTTTCTTCGCAGATTGAGAATACACCCATCCTG
TGTCCTTTTCATTTGCAACCAGTGCCTGAACCTGAAACAGTGTTAAAAAATCAAGAAGTA
GAATTCGGCAGAAATCGAGAGAGGCTTCAGTTTTTTAAGTGGAGTTCAAGAGTTTTTAAG
AATGTGGCAGTGATCCCTCCTGGAACTGGAATGGCTCATCAAATAAACTTAGAATATTTG
TCAAGAGTGGTTTTTGAAGAAAAAGACCTCCTCTTCCCAGACAGTGTAGTCGGCACAGAT
TCACACATAACGATGGTGAATGGTTTAGGGATTCTGGGGTGGGGGGTTGGAGGCATTGAA
ACAGAAGCAGTTATGCTTGGTCTGCCAGTTTCTCTTACTTTACCAGAGGTGGTTGGATGT
GAGTTAACTGGGTCATCAAACCCTTTTGTTACATCCATAGATGTTGTTCTTGGTATTACA
AAGCACCTCAGGCAAGTAGGAGTGGCTGGAAAGTTTGTTGAGTTTTTTGGAAGTGGAGTT
TCACAATTATCTATAGTTGATCGAACTACAATAGCAAACATGTGTCCGGAATATGGTGCT
ATCCTCAGCTTTTTCCCTGTTGACAATGTGACATTAAAACATTTAGAACATACAGGTTTT
AGCAAAGCCAAACTCGAATCAATGGAAACATACCTTAAAGCTGTGAAATTGTTTCGAAAT
GACCAGAATTCTTCAGGAGAACCTGAATACTCCCAGGTGATCCAGATTAATCTGAATTCA
ATAGTTCCATCTGTTAGTGGTCCAAAAAGACCTCAGGATAGAGTTGCTGTGACAGATATG
AAAAGCGATTTCCAGGCTTGCTTAAATGAAAAGGTTGGATTTAAAGGCTTCCAAATTGCA
GCTGAAAAACAAAAGGATATTGTCTCCATTCATTATGAAGGAAGTGAATATAAGCTGTCT
CATGGATCAGTGGTCATTGCTGCAGTTATCAGTTGTACCAATAATTGCAATCCATCTGTC
ATGCTTGCTGCAGGTCTTTTGGCTAAAAAGGCTGTTGAAGCTGGTCTGCGTGTTAAACCT
TATATAAGAACAAGTTTATCTCCAGGCAGTGGGATGGTTACACATTACCTCAGTTCAAGT
GGAGTATTACCATATCTAAGTAAGCTTGGATTTGAAATCGTTGGCTATGGATGTTCAACT
TGTGTGGGAAATACAGCACCCTTATCAGACGCAGTTTTAAATGCAGTAAAACAGGGTGAT
TTGGTTACCTGTGGAATTTTATCTGGAAACAAAAATTTTGAAGGTCGTCTTTGTGATTGT
GTTCGTGCCAATTATCTTGCCTCTCCACCCTTAGTGGTAGCTTATGCCATAGCAGGCACA
GTGAATATAGATTTCCAGACAGAACCTTTAGGTACTGACCCCACCGGCAAGAACATTTAC
CTGCATGATATTTGGCCTAGTCGAGAAGAAGTTCATCGAGTAGAGGAAGAACATGTTATA
CTATCCATGTTTAAAGCATTAAAAGATAAAATAGAAATGGGGAATAAACGGTGGAATTCC
TTAGAAGCACCGGATTCAGTTTTGTTTCCATGGGACTTAAAGTCTACTTATATCAGATGC
CCTTCATTTTTTGATAAACTTACCAAAGAGCCAATTGCACTCCAGGCTATTGAAAATGCC
CATGTCTTATTATATTTGGGAGACTCTGTCACAACAGATCATATATCACCTGCAGGAAGT
ATCGCTAGGAATAGTGCTGCCGCTAAGTATTTGACAAACAGAGGCCTTACCCCTCGTGAA
TTCAACTCTTACGGAGCTCGAAGAGGTAATGATGCTGTAATGACAAGAGGCACTTTTGCA
AATATCAAGCTTTTTAATAAGTTTATTGGAAAACCAGCTCCTAAAACAATTCATTTTCCA
TCAGGACAGACGCTAGATGTATTTGAGGCTGCAGAGCTGTACCAGAAAGAAGGTATCCCA
CTGATTATTTTAGCAGGAAAGAAATATGGTTCAGGAAACTCCAGAGACTGGGCTGCCAAA
GGACCGTATTTACTGGGTGTGAAAGCTGTTTTGGCTGAAAGTTATGAAAAAATACACAAA
GATCATTTGATTGGAATTGGCATAGCTCCACTTCAGTTCCTTCCAGGAGAAAATGCAGAT
TCCTTGGGCCTCTCCGGTAGAGAAACATTTTCTTTAACATTTCCTGAAGAACTGTCTCCT
GGAATTACATTGAATATACAGACAAGCACTGGAAAAGTATTCAGCGTGATTGCTTCGTTT
GAAGATGATGTGGAAATAACATTATACAAACATGGAGGATTATTAAACTTTGTGGCACGA
AAATTCTCATAG

Clone variation with respect to NM_004136.2
2616 c=>t
5' Read Nucleotide Sequence
>OriGene 5' read for NM_004136 unedited
CAATTCCCCCGCCCGTTGCCGCATTGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAA
GCAGAGTTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCG
CGAATTCGGCACGAGGCCCTTCTTCCCCCGCTGGCCCCCTCCCCGGAGGGATAATATGGT
CTCCGGCGATGGACGCCCCAAAAGCAGGATACGCCTTTGAGTACCTTATTGAAACATTAA
ATGACAGTTCACATAAGAAGTTCTTCGATGTATCTAAACTTGGCACCAAGTATGATGTTC
TGCCTTACTCAATACGGGTCTTGTTGGAAGCTGCTGTACGAAATTGTGATGGCTTTTTAA
TGAAGAAGGAAGATGTTATGAACATTTTAGACTGGAAAACCAAACAAAGCAATGTTGAAG
TGCCCTTTTTCCCTGCCCGTGTTCTTCTTCAAGAGTTTACTGGAATACCAGCAATGGTGG
ATTTTGCTGCTATGAGGGAGGCAGTGAAAACTCTTGGAGGTGATCCTGAGAAAGTCCATC
CTGCTTGTCCGACAGATCTTACAGTTGACCATTCTTTACAAATTGACTTCAGTAAATGTG
CAATACAGAATGCACCAAATCCTGGAGGTGGTGACCTGCAGAAAGCAGGAAAGCTCTCTC
CACTTAAAGTGCAGCCTAAGAAGCTTCCCTGCAGAGGCCAGACTACCTGCCGAGGATCTT
GTGATTCTGGAGACTAGGCCGAAACTCAGGACATTTTCTTCGCAGATTGAGAGACACCCA
TNCTGTGTCCTTTTCATTTGCAACCAGTGCCCTGACCTGAAACAGTGTTAAANCATCAAG
AAGTAGTATTCTGCTGACATCGAGAGAGGCTTCAGTTNTTTCAAGTGGAGTTCAAGACGT
TTTCGAGTGTGGCAGTGATCCTTCTGNAAACTGCATGGCTCATCCAATAACTTAGATAAT
TGTCA
3' Read Nucleotide Sequence
>OriGene 3' genomic read for NM_004136 unedited
TAGGATCGAGTTTTTTTTTTTTTTTTTTGGTAACACAAAATTACCCAAGGTATAGTAAAC
AAAGAAGACACAGACAATAAAAACTAACAGATGCCACATTTTGCAAACATAGCATTTGGC
TAGAGGCAGAATTATAAGGTATACATATTAAAACATACATCCNAGACTCTCCTCCTCAAT
TTGAACCAATGTTATCAAGTTTTACTTCATGNNTATAGCCAAAAAAATTAGAGAACTTGA
TTTGTCCTGAAATCAGAATTGCTTGATTATTACTGACCAGTNAACTGGAATGGGAAGTTT
AATCAAAGTTGCCAGGTTTACACCACCCCCGAAAACCTGCGGGGAGACCGTGGGCCGGCC
CAAAAAATTATAAAGATGCTTTTAAAAACATAGCCGCCGGTGGGGGCCCACCCGGATCCC
ACCTTTGGGGGCCCAGGGGGGGGTTCCAGGGCGAGAAATTTTATTTGGCGCCCCGGGGAA
ACCCCCCCTCCAAAAAACAAAAAAAAATGGGCGGGGGGGGCACCCCTTTTCCCCCCCCCC
CGGAGGGGGGGGGGGGGAACCCCCCCCCCCCGGGGCGGGGTTTTTTTAAAAAAAAATACC
CTTTTTTTTCCCCCCCCCCCGGGGGAACAACCCTCTAAAAAAAACCACCCAAATTTTTTT
TTTTCCCCCCCAACAGGGGGAAAATTTTTTTTAAAAAAACAAAGGGTTTTTTCTTCTCCG
GGTGTTTCCCCCCAACGGTTTTGGAGGAA
Restriction Sites NotI-NotI |
ACCN NM_004136
Insert Size 4700 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_004136.1, NP_004127.1
RefSeq Size 3928 bp
RefSeq ORF 2892 bp
Locus ID 3658
UniProt ID P48200
Cytogenetics 15q25.1
Protein Families Druggable Genome
Summary The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Aug 2017
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Documents
Resources
"NM_004136" in other vectors (6)
SKU Description Size Price
RC221385 IREB2 (Myc-DDK-tagged)-Human iron-responsive element binding protein 2 (IREB2) 10 ug
$882.00
RC221385L1 Lenti ORF clone of Human iron-responsive element binding protein 2 (IREB2), Myc-DDK-tagged 10 ug
$1,182.00
RC221385L2 Lenti ORF clone of Human iron-responsive element binding protein 2 (IREB2), mGFP tagged 10 ug
$1,182.00
RC221385L3 Lenti ORF clone of Human iron-responsive element binding protein 2 (IREB2), Myc-DDK-tagged 10 ug
$1,182.00
RC221385L4 Lenti ORF clone of Human iron-responsive element binding protein 2 (IREB2), mGFP tagged 10 ug
$1,182.00
RG221385 IREB2 (tGFP-tagged) - Human iron-responsive element binding protein 2 (IREB2) 10 ug
$789.00 $1,082.00

file-alt Citations

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