YAP1 (NM_006106) Human Untagged Clone
$686.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | YAP1 |
| Synonyms | COB1; YAP; YAP2; YAP65; YKI |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_006106 |
| Insert Size | 4700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_006106.2, NP_006097.1 |
| RefSeq Size | 5128 bp |
| RefSeq ORF | 1365 bp |
| Locus ID | 10413 |
| Cytogenetics | 11q22.1 |
| Domains | WW |
| Protein Families | Druggable Genome |
| Summary | This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Aug 2013 Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks two alternate exons in the coding region, compared to variant 9. The encoded protein (isoform 2) represents the YAP1-1alpha isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_006106" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC214393 | YAP1 (Myc-DDK-tagged)-Human Yes-associated protein 1 (YAP1), transcript variant 2 | 10 ug |
$686.00
|
|
| RC214393L1 | Lenti-ORF clone of YAP1 (Myc-DDK-tagged)-Human Yes-associated protein 1 (YAP1), transcript variant 2 | 10 ug |
$986.00
|
|
| RC214393L2 | Lenti-ORF clone of YAP1 (mGFP-tagged)-Human Yes-associated protein 1 (YAP1), transcript variant 2 | 10 ug |
$986.00
|
|
| RC214393L3 | Lenti-ORF clone of YAP1 (Myc-DDK-tagged)-Human Yes-associated protein 1 (YAP1), transcript variant 2 | 10 ug |
$986.00
|
|
| RC214393L4 | Lenti-ORF clone of YAP1 (mGFP-tagged)-Human Yes-associated protein 1 (YAP1), transcript variant 2 | 10 ug |
$986.00
|
|
| RG214393 | YAP1 (tGFP-tagged) - Human Yes-associated protein 1 (YAP1), transcript variant 2 | 10 ug |
$886.00
|
|
Citations
Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation
Kakiuchi, Takahara, Kasugai et al
Carcinogenesis (2016)
Kakiuchi, Takahara, Kasugai et al
Carcinogenesis (2016)
Cited by 23
AI Summary: OriGene contributed to this study by providing wild-type YAP cDNA (product SC127739), which was used to investigate the role of YAP activation in mesothelial cell transformation and mesothelioma development.
Snippet: MSCV-PGK-BSD vector. Wild type (YAP wt ) and mutant (YAP S127A ) YAP cDNAs were purchased from OriGene (SC127739;Rockville, MD) and Addgene (78715;Cambridge, MA), respectively. Flag-tagged versions of YAP wt and YAP S127A were inserted into the ... Cite SaveSaving
Showing 1-1 of 1 papers.
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