EPOR (NM_000121) Human Untagged Clone
$711.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | EPOR |
| Synonyms | EPO-R |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_000121 |
| Insert Size | 2000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_000121.2, NP_000112.1 |
| RefSeq Size | 1849 bp |
| RefSeq ORF | 1527 bp |
| Locus ID | 2057 |
| UniProt ID | P19235 |
| Cytogenetics | 19p13.2 |
| Domains | FN3 |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway |
| Summary | This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.provided by RefSeq, May 2010 Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_000121" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC211341 | EPOR (Myc-DDK-tagged)-Human erythropoietin receptor (EPOR), transcript variant 1 | 10 ug |
$709.00
|
|
| RC211341L1 | Lenti-ORF clone of EPOR (Myc-DDK-tagged)-Human erythropoietin receptor (EPOR), transcript variant 1 | 10 ug |
$1,009.00
|
|
| RC211341L2 | Lenti-ORF clone of EPOR (mGFP-tagged)-Human erythropoietin receptor (EPOR), transcript variant 1 | 10 ug |
$1,009.00
|
|
| RC211341L3 | Lenti-ORF clone of EPOR (Myc-DDK-tagged)-Human erythropoietin receptor (EPOR), transcript variant 1 | 10 ug |
$1,009.00
|
|
| RC211341L4 | Lenti-ORF clone of EPOR (mGFP-tagged)-Human erythropoietin receptor (EPOR), transcript variant 1 | 10 ug |
$1,009.00
|
|
| RG211341 | EPOR (tGFP-tagged) - Human erythropoietin receptor (EPOR), transcript variant 1 | 10 ug |
$909.00
|
|
Citations
Engineering of erythropoietin receptor for use as an affinity ligand
Hatayama, Ide
Protein Expr. Purif. (2015) 111, 1-8 DOI: 10.1016/j.pep.2015.03.005
Hatayama, Ide
Protein Expr. Purif. (2015) 111, 1-8 DOI: 10.1016/j.pep.2015.03.005
Cited by 5
AI Summary: OriGene’s human EPOR cDNA was used as the template for PCR amplification to engineer and express recombinant erythropoietin receptor variants in this study.
Showing 1-1 of 1 papers.
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