GATA2 (NM_032638) Human Untagged Clone
$686.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | GATA2 |
| Synonyms | DCML; IMD21; MONOMAC; NFE1B |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_032638 |
| Insert Size | 1443 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_032638.3, NP_116027.2 |
| RefSeq Size | 3383 bp |
| RefSeq ORF | 1443 bp |
| Locus ID | 2624 |
| UniProt ID | P23769 |
| Cytogenetics | 3q21.3 |
| Domains | GATA |
| Protein Families | Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors |
| Summary | This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.provided by RefSeq, Mar 2009 Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_032638" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC208554 | GATA2 (Myc-DDK-tagged)-Human GATA binding protein 2 (GATA2), transcript variant 2 | 10 ug |
$686.00
|
|
| RC208554L1 | Lenti ORF clone of Human GATA binding protein 2 (GATA2), transcript variant 2, Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC208554L2 | Lenti ORF clone of Human GATA binding protein 2 (GATA2), transcript variant 2, mGFP tagged | 10 ug |
$986.00
|
|
| RC208554L3 | Lenti ORF clone of Human GATA binding protein 2 (GATA2), transcript variant 2, Myc-DDK-tagged | 10 ug |
$986.00
|
|
| RC208554L4 | Lenti ORF clone of Human GATA binding protein 2 (GATA2), transcript variant 2, mGFP tagged | 10 ug |
$986.00
|
|
| RG208554 | GATA2 (tGFP-tagged) - Human GATA binding protein 2 (GATA2), transcript variant 2 | 10 ug |
$886.00
|
|
| SC321007 | GATA2 (untagged)-Human GATA binding protein 2 (GATA2), transcript variant 2 | 10 ug |
$686.00
|
|
Citations
GATA2 Germline Mutations Impair GATA2 Transcription, Causing Haploinsufficiency: Functional Analysis of the p.Arg396Gln Mutation
Cortés-Lavaud, Landecho, Maicas et al
J. Immunol. (2015) 194 (5), 2190-8 DOI: 10.4049/jimmunol.1401868
Cortés-Lavaud, Landecho, Maicas et al
J. Immunol. (2015) 194 (5), 2190-8 DOI: 10.4049/jimmunol.1401868
Cited by 32
Transcription Factors with Conserved Binding Sites Near ATOH1 on the POU4F3 Gene Enhance the Induction of Cochlear Hair Cells
Ikeda, Pak, Chavez et al
Mol. Neurobiol. (2014)
Ikeda, Pak, Chavez et al
Mol. Neurobiol. (2014)
Cited by 46
AI Summary: OriGene contributed to this study by providing all the plasmids used for transfection, including those encoding the transcription factors tested for their effects on cochlear hair cell induction.
Snippet: 2). All plasmids were purchased from OriGene (Rockville, MD, USA). Five days after transfection, GFP fluorescence was evaluated, and immunolabelling was carried out to detect myosin 7A+, which in the inner ear is a specific marker for the HC phenotype [18]. ... Cite SaveSaving
Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia
Hahn, Chong, Carmichael et al
Nat. Genet. (2011) 43 (10), 1012-7 DOI: 10.1038/ng.913
Hahn, Chong, Carmichael et al
Nat. Genet. (2011) 43 (10), 1012-7 DOI: 10.1038/ng.913
Cited by 606
AI Summary: OriGene's pCMV6-XL6-GATA2 expression clone was used to generate mutant GATA2 constructs, enabling the functional analysis of heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia in this study.
Snippet: constructs. An expression clone (pCMV6-XL6-GATA2) containing a 3.7-kb GATA2 cDNA insert was obtained from OriGene, and p.Thr354Met, p.Thr355del and p.Leu359Val mutants were generated by site-directed mutagenesis.
Showing 1-3 of 3 papers.
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