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GATA4 (NM_002052) Human Untagged Clone

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SKU
SC124037
GATA4 (untagged)-Human GATA binding protein 4 (GATA4)
  $457.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol GATA4
Synonyms ASD2; TACHD; TOF; VSD1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC124037 sequence for NM_002052 edited (data generated by NextGen Sequencing)
ATGTATCAGAGCTTGGCCATGGCCGCCAACCACGGGCCGCCCCCCGGTGCCTACGAGGCGGGCGGCCCCG
GCGCCTTCATGCACGGCGCGGGCGCCGCGTCCTCGCCAGTCTACGTGCCCACACCGCGGGTGCCCTCCTC
CGTGCTGGGCCTGTCCTACCTCCAGGGCGGAGGCGCGGGCTCTGCGTCCGGAGGCGCCTCGGGCGGCAGC
TCCGGTGGGGCCGCGTCTGGTGCGGGGCCCGGGACCCAGCAGGGCAGCCCGGGATGGAGCCAGGCGGGAG
CCGACGGAGCCGCTTACACCCCGCCGCCGGTGTCGCCGCGCTTCTCCTTCCCGGGGACCACCGGGTCCCT
GGCGGCCGCCGCCGCCGCTGCCGCGGCCCGGGAAGCTGCGGCCTACAGCAGTGGCGGCGGAGCGGCGGGT
GCGGGCCTGGCGGGCCGCGAGCAGTACGGGCGCGCCGGCTTCGCGGGCTCCTACTCCAGCCCCTACCCGG
CTTACATGGCCGACGTGGGCGCGTCCTGGGCCGCAGCCGCCGCCGCCTCCGCCGGCCCCTTCGACAGCCC
GGTCCTGCACAGCCTGCCCGGCCGGGCCAACCCGGCCGCCCGACACCCCAATCTCGATATGTTTGACGAC
TTCTCAGAAGGCAGAGAGTGTGTCAACTGTGGGGCTATGTCCACCCCGCTCTGGAGGCGAGATGGGACGG
GTCACTATCTGTGCAACGCCTGCGGCCTCTACCACAAGATGAACGGCATCAACCGGCCGCTCATCAAGCC
TCAGCGCCGGCTGTCCGCCTCCCGCCGAGTGGGCCTCTCCTGTGCCAACTGCCAGACCACCACCACCACG
CTGTGGCGCCGCAATGCGGAGGGCGAGCCTGTGTGCAATGCCTGCGGCCTCTACATGAAGCTCCACGGGG
TCCCCAGGCCTCTTGCAATGCGGAAAGAGGGGATCCAAACCAGAAAACGGAAGCCCAAGAACCTGAATAA
ATCTAAGACACCAGCAGCTCCTTCAGGCAGTGAGAGCCTTCCTCCCGCCAGCGGTGCTTCCAGCAACTCC
AGCAACGCCACCACCAGCAGCAGCGAGGAGATGCGTCCCATCAAGACGGAGCCTGGTCTGTCATCTCACT
ACGGGCACAGCAGCTCCGTGTCCCAGACGTTCTCAGTCAGTGCGATGTCTGGCCATGGGCCCTCCATCCA
CCCTGTCCTCTCGGCCCTGAAGCTCTCCCCACAAGGCTATGCGTCTCCCGTCAGCCAGTCTCCACAGACC
AGCTCCAAGCAGGACTCTTGGAACAGCCTGGTCTTGGCCGACAGTCACGGGGACATAATCACTGCGTAA

Clone variation with respect to NM_002052.3
353 c=>n;354 g=>n;355 g=>n;356 c=>n;357 c=>n;358 g=>n;359 c=>n;360 c=>n;361 g=>n;1107 c=>t
5' Read Nucleotide Sequence
>OriGene 5' read for NM_002052 unedited
GGTCAGATTTGTATACGACTCATATAGGCGGCCGCGAATTCGCACGAGCGCAGGGCCGCG
AGAGGCTTCGTCGCCGCTGCAGCTCCGGGGGCTCCCAGGGGAGCGTGCGCGGAACCTCCA
GGCCCAGCAGGACCCCGGCTGCGGCGAGGAGGAAGGAGCCAGCCTAGCAGCTTCTGCGCC
TGTGGCCGCGGGTGTCCTGGAGGCCTCTCGGTGTGACGAGTGGGGGACCCGAAGGCTCGT
GCGCCACCTCCAGGCCTGGACGCTGCCCTCCGTCTTCTGCCCCCAATAGGTGCGCCGGAC
CTTCAGGCCCTGGGGTGAATTCAGCTGCTCCTACATCAGCTTCCGGAACCACCAAAAATT
CAAATTGGGATTTTCCGGAGTAAACAAGAGCCTAGAGCCCTTTGCTCAATGCTGGATTTA
ATACGTATATATTTTTAAGCGAGTTGGTTTTTTCCCCTTTGATTTTTGATCTTCGCGACA
GTTCCTCCCACGCATATTATCGTTGTTGCCGTCGTTTTCTCTCCCCGCGTGGCTCCTTGA
CCTGCGAGGGAGAGAGAGGACACCGAAGCCGGGAGCTCGCAGGGACCATGTATCAGAGCT
TGGCCATGGCCGCCAACCACGGGCCGCCCCCCGGTGCCTACGAGGCGGGCGGCCCCGGCG
CCTTCATGCACGGCGCGGGCGCCGCGTCCTCGCCAGTCTACGTGCCCACACCGCGGGGTG
CCCTCCTCCGTGCTGGGCCTGTCCTACCTCCAGGGCGGAGGCGCGGGCTCTGCGTCCGGG
AGCGCCCTCGGCGGCAGCTCCGGGTGGGGCCCGGTCTGTTGCCGGGCCCGGNACCCCACA
GGGCAGCCCGGGGAGGACCCAGCGCGGGGCCAACGAGCCGCTTACCCCCCGCCGCCGTGT
CTCCCGCCCTTTTCCTCG
3' Read Nucleotide Sequence
>OriGene 3' read for NM_002052 unedited
GCATGGCAACTTCCAGGCCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGG
ATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTGT
TTTTTAAAGAGGAATACAGATAAATTTATTAGTTAAATACTGATTTTCCAGCCATTTCAC
CTTAAGACAATGTTAACAGGTTTGTGGGTTAGGGAGGGTATACGAGGGGGCCTTTGGAAG
AAAACAATGTAAATGATGATTAAAACAGAATCTTGGTTCAAAGGTATTCTCTGCTACAGC
CAGTAGGATTTTGGAGTGAGGGGTCTGGGCGTGTGGGGAGGCGTAGTAATGCCACAGTCA
GCTACAGCTCTGCTGAGAAAGAGGAAGGAGTCTCCATGAGCTCCAGCATCAGGGGCAGAA
ACAGCAATGTGCAGAGGAGAACGCGGCAGATCCCGGAGCAGCTCAGAGTCGGAGGCTCCC
TCCAGGCCCCCCTGCCGTGTCTTAGCAGTCGTCTTCTTTCCAGGAATTCTGTTGTGTTGT
GTTTGTTTGCTTCGAATTCGTGTTGCAGAATCTCTGGCTTTTTGCCTCCTGGACAAAAGA
CTTCTGCCGGGGCGAAGCTGCAAGTCCTTGAGGACTCTGGCTTGCATCTTGACCAAGGGT
AGGAGGACCAACAGACCACAGGTGGGCCACCTTGGGACACTCTGCCCCTGACAGGAATTT
GTCACTTACCTCTCCCAGAAGACCTCAGGCTGGCTGATGCTGCCAATGCTTGACACAAAC
GTTTGTTTTCTAAACCTTTATTTGACCGTGACAAGGCTCATGACTCAGGGGTCGTTGTAA
TCCAACCTTGTTCAGGAAAAATTCAACG
Restriction Sites Please inquire |
ACCN NM_002052
Insert Size 3600 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_002052.2, NP_002043.2
RefSeq Size 3372 bp
RefSeq ORF 1329 bp
Locus ID 2626
UniProt ID P43694
Cytogenetics 8p23.1
Protein Families Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors
Summary This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. provided by RefSeq, Apr 2015
Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
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Documents
Resources
"NM_002052" in other vectors (6)
SKU Description Size Price
RC210945 GATA4 (Myc-DDK-tagged)-Human GATA binding protein 4 (GATA4) 10 ug
$457.00
RC210945L1 Lenti ORF clone of Human GATA binding protein 4 (GATA4), Myc-DDK-tagged 10 ug
$757.00
RC210945L2 Lenti ORF clone of Human GATA binding protein 4 (GATA4), mGFP tagged 10 ug
$757.00
RC210945L3 Lenti ORF clone of Human GATA binding protein 4 (GATA4), Myc-DDK-tagged 10 ug
$757.00
RC210945L4 Lenti ORF clone of Human GATA binding protein 4 (GATA4), mGFP tagged 10 ug
$757.00
RG210945 GATA4 (tGFP-tagged) - Human GATA binding protein 4 (GATA4) 10 ug
$489.00 $657.00

file-alt Citations

Direct Reprogramming of Human Fibroblasts to Hepatocyte-Like Cells by Synthetic Modified mRNAs
Simeonov, Uppal
PLoS ONE (2014) 9 (6), e100134 DOI: 10.1371/journal.pone.0100134
Cited by 92
AI Summary: OriGene contributed plasmids containing human open reading frames (ORFs) for C/EBPA, FOXA1, FOXA2, FOXA3, GATA4, GATA6, HHEX, HNF1A, HNF1B, HNF4A, and HNF6A, which were used as templates for generating the synthetic mRNAs essential for direct reprogramming of human fibroblasts to hepatocyte-like cells in this study.
Snippet: Open reading frame (ORF) PCR amplifications of DNA encoding C/EBPA FOXA1, FOXA2, FOXA3, GATA4, GATA6, HHEX, HNF1A, HNF1B, HNF4A, and HNF6Awere templated from DNA plasmids containing each of the respective human ORFs (Origene, Rockville, ... Cite SaveSaving
FigureFigureFigure
A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas
Agnihotri, Wolf, Munoz et al
J. Exp. Med. (2011) 208 (4), 689-702 DOI: 10.1084/jem.20102099
Cited by 95
AI Summary: In this study, OriGene’s GATA4 expression plasmid (RC210307) and GATA4 shRNA (TF311647) were used to modulate GATA4 levels in glioblastoma and astrocyte cells, enabling the authors to demonstrate the tumor suppressor role of GATA4 in repressing malignant astrocytoma formation.
FigureFigureFigure
GATA4 is a regulator of astrocyte cell proliferation and apoptosis in the human and murine central nervous system
Agnihotri, Wolf, Picard et al
Oncogene (2009) 28 (34), 3033-46 DOI: 10.1038/onc.2009.159
Cited by 61
AI Summary: OriGene products contributed to this study by providing the GATA4 expression plasmid (OriGene, Cat# RC210377) and GATA4 shRNA constructs (OriGene, Cat# TG312894), which were used for GATA4 overexpression and knockdown experiments to investigate its role in astrocyte proliferation and apoptosis.
Loss of GATA5 expression due to gene promoter methylation induces growth and colony formation of hepatocellular carcinoma cells
Xia, Gong, Zhang et al
Oncology … (2016)
Snippet: Expression vector and gene transfection. Full-length GATA4 and GATA5 cDNA were purchased from Orignene Tech- nologies, Inc. (Rockville, MD, USA) and subcloned into pCMV6‑XL4 (OriGene Technologies, Inc.) in Escherichia coli DH5α cells (Invitrogen Life ... Cite SaveSaving
Showing 1-4 of 4 papers.
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