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RUNX2 (NM_004348) Human Untagged Clone

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SKU
SC123971
RUNX2 (untagged)-Human runt-related transcription factor 2 (RUNX2), transcript variant 3
  $473.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol RUNX2
Synonyms AML3; CBFA1; CCD; CCD1; OSF-2; OSF2; PEA2aA; PEBP2A1; PEBP2A2; PEBP2aA; PEBP2aA1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC123971 sequence for NM_004348 edited (data generated by NextGen Sequencing)
ATGCGTATTCCCGTAGATCCGAGCACCAGCCGGCGCTTCAGCCCCCCCTCCAGCAGCCTG
CAGCCCGGCAAAATGAGCGACGTGAGCCCGGTGGTGGCTGCGCAACAGCAGCAGCAACAG
CAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGGAGGCGGCG
GCGGCGGCTGCGGCGGCGGCGGCGGCTGCGGCGGCGGCAGCTGCAGTGCCCCGGTTGCGG
CCGCCCCACGACAACCGCACCATGGTGGAGATCATCGCCGACCACCCGGCCGAACTCGTC
CGCACCGACAGCCCCAACTTCCTGTGCTCGGTGCTGCCCTCGCACTGGCGCTGCAACAAG
ACCCTGCCCGTGGCCTTCAAGGTGGTAGCCCTCGGAGAGGTACCAGATGGGACTGTGGTT
ACTGTCATGGCGGGTAACGATGAAAATTATTCTGCTGAGCTCCGGAATGCCTCTGCTGTT
ATGAAAAACCAAGTAGCAAGGTTCAACGATCTGAGATTTGTGGGCCGGAGTGGACGAGGC
AAGAGTTTCACCTTGACCATAACCGTCTTCACAAATCCTCCCCAAGTAGCTACCTATCAC
AGAGCAATTAAAGTTACAGTAGATGGACCTCGGGAACCCAGAAGGCACAGACAGAAGCTT
GATGACTCTAAACCTAGTTTGTTCTCTGACCGCCTCAGTGATTTAGGGCGCATTCCTCAT
CCCAGTATGAGAGTAGGTGTCCCGCCTCAGAACCCACGGCCCTCCCTGAACTCTGCACCA
AGTCCTTTTAATCCACAAGGACAGAGTCAGATTACAGACCCCAGGCAGGCACAGTCTTCC
CCGCCGTGGTCCTATGACCAGTCTTACCCCTCCTACCTGAGCCAGATGACGTCCCCGTCC
ATCCACTCTACCACCCCGCTGTCTTCCACACGGGGCACTGGGCTTCCTGCCATCACCGAT
GTGCCTAGGCGCATTTCAGATGATGACACTGCCACCTCTGACTTCTGCCTCTGGCCTTCC
ACTCTCAGTAAGAAGAGCCAGGCAGGTGCTTCAGAACTGGGCCCTTTTTCAGACCCCAGG
CAGTTCCCAAGCATTTCATCCCTCACTGAGAGCCGCTTCTCCAACCCACGAATGCACTAT
CCAGCCACCTTTACTTACACCCCGCCAGTCACCTCAGGCATGTCCCTCGGTATGTCCGCC
ACCACTCACTACCACACCTACCTGCCACCACCCTACCCCGGCTCTTCCCAAAGCCAGAGT
GGACCCTTCCAGACCAGCAGCACTCCATATCTCTACTATGGCACTTCGTCAGGATCCTAT
CAGTTTCCCATGGTGCCGGGGGGAGACCGGTCTCCTTCCAGAATGCTTCCGCCATGCACC
ACCACCTCGAATGGCAGCACGCTATTAAATCCAAATTTGCCTAACCAGAATGATGGTGTT
GACGCTGATGGAAGCCACAGCAGTTCCCCAACTGTTTTGAATTCTAGTGGCAGAATGGAT
GAATCTGTTTGGCGACCATATTGA

Clone variation with respect to NM_004348.3
5' Read Nucleotide Sequence
>OriGene 5' read for NM_004348 unedited
ACTGCAGTGCACTTNCGAGAGNATATGGCGAACGCGAACTGGGGGCCAGGTCTCGCCTTC
ACCCCCCCAATTTCCTCCTTGCCCTTTATTTCCACCCTCCTCCCCCTCCCCCGGCGGGTT
CGCTAACTTGTGGCTGTGGGTGATGCGTATTCCCGTAGATCCGAGCACCAGCCGGCGCTT
CAGCCCCCCCTCCAGCAGCCTGCAGCCCGGCAAAATGAGCGACGTGAGCCCGGTGGTGGC
TGCGCAACAGCAGCAGCAACAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAACAGCA
GCAGCAGCAGCAGGAGGCGGCGGCGGCGGCTGCGGCGGCGGCGGCGGCTGCGGCGGCGGC
AGCTGCAGTGCCCCGGTTGCGGCCGCCCCACGACAACCGCACCATGGTGGAGATCATCGC
CGACCACCCGGCCGAACTCGTCCGCACCGACAGCCCCAACTTCCTGTGCTCGGTGCTGCC
CTCGCACTGGCGCTGCAACAAGACCCTGCCCGTGGCCTTCAAGGTGGTAGCCCTCGGAGA
GGTACCAGATGGGACTGTGGTTACTGTCATGGCGGGTAACGATGAAAATTATTCTGCTGA
GCTCCGGAATGCCTCTGCTGTTATGAAAAACCAAGTAGCAAGGTTCAACGATCTGAGATT
TGTGGGCCGGAGTGGACGAGGCAAGAGTTTCACCTTGACCATAACCGTCTTCACAATCCT
CCCCAGTAGCTACCTAT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_004348 unedited
GTATTCTTTGTACCCGCCTGACAGTTACCACAGTCCCATCTGGTAGCTCTCCGAGGGCTA
CCACCTTGAAGGCCACGGGCAGGGTTTTGTTGCAGCGCCAGTGCGAGGGCAGCACCGAGC
ACAGGAAGTTGGGGCTGTCGGTGCGGACGAGTTCGGCCGGGTGGTCGGCGATGATCTCCA
CCATGGTGCGGTTGTCGTGGGGCGGCCGCAACCGGGGCACTGCAGCTGCCGCCGCCGCAG
CCGCCGCCGCCGCCGCAGCCGCCGCCGCCGCCTCCTGCTGCTGCTGCTGCTGTTGCTGCT
GCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTGTTGCGCAGCCACCACCGGGC
TCACGTCGCTCATTTTGCCGGGCTGCAGGCTGCTGGAGGGGGGGCTGAAGCGCCGGCTGG
TGCTCGGATCTACGGGAATACGCATCACAACAGCCACAAGTTAGCGAAGTGGCCGGGGGA
GGGGGAGGAGGGTGGAAATGAGGGGCAAGGAGGAAATTGGGGGGGTGAANGCNANNACNN
GNTGCNGAANGNNNGANNNGCCCNAGAGTGAATCGAGATTACAAGAATTTTGGACAGGAT
TTACTAAATGCGACGCTTCGCTTATAGAACAAGTAGCCTACAACACCATGTCTCGACTGG
CATATCGGTGACCATTTTTCACGTCCTCTACCGCGGGCCCTGGTGTATTAATCTGAACGA
GACTGTGTTATGGGAGAGAGGACGACCTCGCCTTGACGTTGTCGAAGACGCGCCGCAGAT
GCCAATATGAGGTCACTGATGTTGGAATCGTCGAGTAATTGGGACGATTGCAGACAGCT
Restriction Sites NotI-NotI |
ACCN NM_004348
Insert Size 5000 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_004348.3, NP_004339.3
RefSeq Size 5720 bp
RefSeq ORF 1524 bp
Locus ID 860
Cytogenetics 6p21.1
Domains Runt
Protein Families Druggable Genome, Transcription Factors
Summary This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. provided by RefSeq, Jul 2016
Transcript Variant: This variant (3) is transcribed from an alternate promoter (P2) and contains a different segment for the 5' UTR and 5' coding region than variant 1. It encodes a protein (isoform c) with a shorter and distinct N-terminus when it is compared to isoform a.
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Documents
Resources
"NM_004348" in other vectors (6)
SKU Description Size Price
RC213097 RUNX2 (Myc-DDK-tagged)-Human runt-related transcription factor 2 (RUNX2), transcript variant 3 10 ug
$472.00
RC213097L1 Lenti ORF clone of Human runt-related transcription factor 2 (RUNX2), transcript variant 3, Myc-DDK-tagged 10 ug
$772.00
RC213097L2 Lenti ORF clone of Human runt-related transcription factor 2 (RUNX2), transcript variant 3, mGFP tagged 10 ug
$772.00
RC213097L3 Lenti ORF clone of Human runt-related transcription factor 2 (RUNX2), transcript variant 3, Myc-DDK-tagged 10 ug
$772.00
RC213097L4 Lenti ORF clone of Human runt-related transcription factor 2 (RUNX2), transcript variant 3, mGFP tagged 10 ug
$772.00
RG213097 RUNX2 (tGFP-tagged) - Human runt-related transcription factor 2 (RUNX2), transcript variant 3 10 ug
$489.00 $672.00

file-alt Citations

Deregulation of RUNX2 by miR-320a deficiency impairs steroidogenesis in cumulus granulosa cells from polycystic ovary syndrome (PCOS) patients
Zhang, Wang, Yan et al
Biochem. Biophys. Res. Commun. (2016)
AI Summary: OriGene contributed to this study by providing the pCMV6-XL4-RUNX2 plasmid, which was used to investigate the regulatory effects of RUNX2 in cumulus granulosa cells related to PCOS.
Snippet: Reporter assay. pLightSwitch-Luc-Blank, pLightSwitch-Luc-RUNX2/3′UTR, pLightSwitch-Luc-CYP11A1 and pLightSwitch-Luc-CYP19A1 were obtained from SwitchGear Genomics (Shanghai, China). pCMV6-XL4-RUNX2 was purchased from OriGene (Rockville, ... Cite SaveSaving
Showing 1-1 of 1 papers.
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