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GPATCH3 (NM_022078) Human Untagged Clone

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SKU
SC122923
GPATCH3 (untagged)-Human G patch domain containing 3 (GPATCH3)
  $490.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol GPATCH3
Synonyms GPATC3
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_022078 edited
CCAAGATGGCGGTGCCCGGCGAGGCGGAGGAGGAGGCGACAGTTTACCTGGTAGTGAGCG
GTATCCCCTCCGTGTTGCGCTCGGCCCATTTACGGAGCTATTTTAGCCAGTTCCGAGAAG
AGCGCGGCGGTGGCTTCCTCTGTTTCCACTACCGGCATCGGCCTGAGCGGGCCCCTCCGC
AGGCCGCTCCTAACTCTGCCCTAATTCCTACCGACCCAGCCGCTGAGGGCCAGCTTCTCT
CTCAGACTTCGGCCACCGATGTCCGGCCTCTCTCCACTCGAGACTCTACTCCAATCCAGA
CCCGCACCTGCTGCTGCGTCATCTCGGTAAGGGGGTTGGCTCAAGCTCAGAGGCTTATTC
GCATGTACTCGGGCCGCCGGTGGCTGGATTCTCACGGGACTTGGCTACCGGGTCGCTGTC
TCATCCGCAGACTTCGGCTACCTACGGAGGCATCAGGTCTGGGCTCCTTTCCCTTCAAGA
CCCGGAAGGAACTGCAGAGTTGGAAGGCAGAGAATGAAGCCTTCACCCTGGCTGACCTGA
AGCAACTGCCGGAGCTGAACCCACCAGTGCTGATGCCCAGAGGGAATGTGGGGACTCCCC
TGCGGGTCTTTTTGGAGTTGATCCGGGCCTGCCGCCTACCCCCTCGGATCATCACCCAGC
TGCAGCTCCAGTTCCCCAAGACAGGTTCCTCCCGGCGCTACGGCAATGTGCCTTTTGAGT
ATGAGGACTCAGAGACTGTGGAGCAGGAAGAGCTTGTGTATACAGCAGAGGGTGAAGAAA
TACCCCAAGGAACCTACCTGGCAGATATACCAGCCAGCCCCTGTGGAGAGCCTGAGGAAG
AAGTGGGGAAGGAAGAGGAAGAAGAGTCTCACTCAGATGAGGACGATGACCGGGGTGAGG
AATGGGAACGGCATGAAGCGCTGCATGAGGACGTGACCGGGCAGGAGCGGACCACTGAGC
AGCTCTTTGAGGAGGAGATTGAGCTCAAGTGGGAGAAGGGTGGCTCTGGCCTGGTGTTTT
ATACTGATGCCCAGTTCTGGCAGGAGGAAGAAGGAGATTTTGATGAACAGACAGCCGATG
ACTGGGATGTGGACATGAGTGTGTACTATGACAGAGATGGTGGAGACAAGGATGCCCGAG
ACTCTGTCCAAATGCGTCTGGAACAGAGACTCCGAGATGGACAGGAAGATGGCTCTGTGA
TCGAACGCCAGGTGGGCACCTTTGAGCGCCACACCAAGGGCATTGGGCGGAAGGTGATGG
AGCGGCAGGGCTGGGCTGAGGGCCAGGGCCTGGGCTGCAGGTGCTCAGGGGTGCCTGAGG
CCCTGGATAGTGATGGCCAACACCCCAGATGCAAGCGTGGATTGGGGTACCATGGAGAGA
AGCTACAGCCATTTGGGCAACTGAAGAGGCCCCGTAGAAATGGCTTGGGGCTCATCTCCA
CCATCTATGATGAGCCTCTACCCCAAGACCAGACGGAGTCACTGCTCCGCCGCCAGCCAC
CCACCAGCATGAAGTTTCGGACAGACATGGCCTTTGTGAGGGGTTCCAGTTGTGCTTCAG
ACAGCCCCTCATTGCCTGACTGACCGGGTTGGGGGCTTCCTTTCATAGCTACATGATGAA
AACCCTCTGCCCTGGCCTCATCTACCACTGAAGCAGAAAGGAGTCTGGGAGCAGCAGTCT
TCGTGGCTGGTTCAGGGTGTTTTGTTCCGAGCCTGCCTGCCTGCCGGTTCTATACCTCAG
GGGCATTTTTACAAAAAGCCCCCTCCCGTCCCCTCCCCTTGGATATTAGGGGTAACGACC
GCTTGTCTTTGGTCTCTAACCCTAATCTCTGGGCTTGCCCTTTGCCTCCTGCAGAACTTT
GAAAAGCTGGGTTGAGTGAGGCTATCAGCACAGCCTTCCTTGGGGACTCTGAAGGTGTCC
CCACGAAGGCCAGAAAGGGGGAAAGGGACCTGGGCGAGGAGAGGATTTGTGGTGCTTGGA
AGAGCCGGCCTTGGGTGGGCCCTCCACCGCCTCTACCCTCACTGGGTGGGACTGCCAGCG
GAGAGTCCGCGGGAGGTGGCTTGGGTGTGCGACGTCACGGAAGAATAAAGACGTTTACTA
CTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AA
5' Read Nucleotide Sequence
>OriGene 5' read for NM_022078 unedited
NNGGGGGGAGTACAACATTTGTNATACGACTCACTATAGGCGGCCGCGNAATTCGCACNG
GCCAATAGGCGGTGCCCGGCGAGGCGGAGGAGGAGGCGACAGTTTACCTGGTAGTGAGCG
GTATCCCCTCCGTGTTGCGCTCGGCCCATTTACGGAGCTATTTTAGCCAGTTCCGAGAAG
AGCGCGGCGGTGGCTTCCTCTGTTTCCACTACCGGCATCGGCCTGAGCGGGCCCCTCCGC
AGGCCGCTCCTAACTCTGCCCTAATTCCTACCGACCCAGCCGCTGAGGGCCAGCTTCTCT
CTCAGACTTCGGCCACCGATGTCCGGCCTCTCTCCACTCGAGACTCTACTCCAATCCAGA
CCCGCACCTGCTGCTGCGTCATCTCGGTAAGGGGGTTGGCTCAAGCTCAGAGGCTTATTC
GCATGTACTCGGGCCGCCGGTGGCTGGATTCTCACGGGACTTGGCTACCGGGTCGCTGTC
TCATCCGCAGACTTCGGCTACCTACGGAGGCATCAGGTCTGGGCTCCTTTCCCTTCAAGA
CCCGGAAGGAACTGCAGAGTTGGAAGGCAGAGAATGAAGCCTTCACCCTGGCTGACCTGA
AGCAACTGCCGGAGCTGAACCCACCAGTGCTGATGCCCAGAGGGAATGTGGGGACTCCCC
TGCGGGTCTTTTTGGAGTTGATCCGGGCCTGCCGCCTACCCCCTCGGATCATCACCCAGC
TGCAGCTCCAGTTCCCCAAGACAGGTTCCTCCCGGCGCTACGGCAATGTGCCTTTTGAGT
ATGAGGACTCANAGACTGTGGAGCAGGAAGAGCTTGTGTATACAGCAGAGGGTGAAGGAA
TACCCC
Restriction Sites Please inquire |
ACCN NM_022078
Insert Size 2171 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_022078.1, NP_071361.1
RefSeq Size 2123 bp
RefSeq ORF 1578 bp
Locus ID 63906
UniProt ID Q96I76
Cytogenetics 1p36.11
Summary Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768).UniProtKB/Swiss-Prot Function
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"NM_022078" in other vectors (4)
SKU Description Size Price
RC203010 GPATCH3 (Myc-DDK-tagged)-Human G patch domain containing 3 (GPATCH3) 10 ug
$489.00
RC203010L3 Lenti ORF clone of Human G patch domain containing 3 (GPATCH3), Myc-DDK-tagged 10 ug
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RC203010L4 Lenti ORF clone of Human G patch domain containing 3 (GPATCH3), mGFP tagged 10 ug
$789.00
RG203010 GPATCH3 (tGFP-tagged) - Human G patch domain containing 3 (GPATCH3) 10 ug
$489.00 $689.00

file-alt Citations

Whole-Exome Sequencing of Congenital Glaucoma Patients Reveals Hypermorphic Variants in GPATCH3, a New Gene Involved in Ocular and Craniofacial Development
Ferre-Fernández, Aroca-Aguilar, Medina-Trillo et al
Sci Rep (2017) 7, 46175 DOI: 10.1038/srep46175
AI Summary: OriGene’s GPATCH3 cDNA clone (NM_022078, SC122923) was used as the source of wild-type GPATCH3 coding sequence for functional studies in this paper.
Snippet: The wild-type GPATCH3 coding sequence obtained from a commercial cDNA (Origene, NM_022078, SC122923) was subcloned into the XbaI and BamHI restriction sites of the modified mammalian cell expression vector pcDNA3.1(-) (Cterminal Myc-Tagged)8 by ... Cite SaveSaving
FigureFigureFigure
Showing 1-1 of 1 papers.
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