IL37 (NM_014439) Human Untagged Clone
SKU
SC122809
IL37 (untagged)-Human interleukin 1 family, member 7 (zeta) (IL1F7), transcript variant 1
$450.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | IL37 |
| Synonyms | FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H; IL-1H4; IL-1RP1; IL-23; IL-37; IL1F7; IL1H4; IL1RP1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_014439 |
| Insert Size | 760 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_014439.3, NP_055254.2 |
| RefSeq Size | 787 bp |
| RefSeq ORF | 657 bp |
| Locus ID | 27178 |
| UniProt ID | Q9NZH6 |
| Cytogenetics | 2q14.1 |
| Protein Families | Druggable Genome, Secreted Protein |
| Summary | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. provided by RefSeq, Jul 2008 Transcript Variant: This variant (1) encodes the longest isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_014439" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC204638 | IL37 (Myc-DDK-tagged)-Human interleukin 1 family, member 7 (zeta) (IL1F7), transcript variant 1 | 10 ug |
$450.00
|
|
| RC204638L1 | Lenti ORF clone of Human interleukin 1 family, member 7 (zeta) (IL1F7), transcript variant 1, Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC204638L2 | Lenti ORF clone of Human interleukin 1 family, member 7 (zeta) (IL1F7), transcript variant 1, mGFP tagged | 10 ug |
$750.00
|
|
| RC204638L3 | Lenti ORF clone of Human interleukin 1 family, member 7 (zeta) (IL1F7), transcript variant 1, Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC204638L4 | Lenti ORF clone of Human interleukin 1 family, member 7 (zeta) (IL1F7), transcript variant 1, mGFP tagged | 10 ug |
$750.00
|
|
| RG204638 | IL37 (tGFP-tagged) - Human interleukin 1 family, member 7 (zeta) (IL1F7), transcript variant 1 | 10 ug |
$650.00
|
|
Citations
IL-37 inhibits IL-18-induced tubular epithelial cell expression of pro-inflammatory cytokines and renal ischemia-reperfusion injury
Yang, Zhang, Lian et al
Kidney Int. (2014)
Yang, Zhang, Lian et al
Kidney Int. (2014)
Cited by 105
AI Summary: OriGene’s pCMV6-XL5-IL-37 plasmid was used to transfect tubular epithelial cells, enabling the study of IL-37’s role in suppressing pro-inflammatory cytokine expression and renal injury in this research.
Snippet: conjugated secondary antibody (Sigma) was used. Cell transfection. PT-2 TECs were transfected with pCMV6-XL5-IL-37 (OriGene, Rockville, MD) or pCMV6-XL5 empty vector using Lipofectamine (Invitrogen). After 24 h, the medium ... Cite SaveSaving
Showing 1-1 of 1 papers.
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