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SLC22A8 (NM_004254) Human Untagged Clone

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SKU
SC122673
SLC22A8 (untagged)-Human solute carrier family 22 (organic anion transporter), member 8 (SLC22A8), transcript variant 1
  $808.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol SLC22A8
Synonyms OAT3
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_004254 edited
AGCTTGTTAGAGCTGAGCTGCCCTACTACAGCAGCTGCCGGCCCCTAGGACAGAGCAGGG
ACCTCAACTACACTGATCACCAGCCCCATCGGATCCAGACCCGGCCACCAGCTCTGGCTC
GTCTTGCCCCAGTGCCATGACCTTCTCGGAGATCCTGGACCGTGTGGGAAGCATGGGCCA
TTTCCAGTTCCTGCATGTAGCCATACTGGGCCTCCCGATCCTCAACATGGCCAACCACAA
CCTGCTGCAGATCTTCACAGCCGCCACCCCTGTCCACCACTGTCGCCCGCCCCACAATGC
CTCCACAGGGCCTTGGGTGCTCCCCATGGGCCCAAATGGGAAGCCTGAGAGGTGCCTCCG
TTTTGTACATCCGCCCAATGCCAGCCTGCCCAATGACACCCAGAGGGCCATGGAGCCATG
CCTGGATGGCTGGGTCTACAACAGCACCAAGGACTCCATTGTGACAGAGTGGGACTTGGT
GTGCAACTCCAACAAACTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGGTATACTGAT
TGGAGGGCTCGTGCTTGGAGACCTGTCTGACAGGTTTGGCCGCAGGCCCATCCTGACCTG
CAGCTACCTGCTGCTGGCAGCCAGCGGCTCCGGTGCAGCCTTCAGCCCCACCTTCCCCAT
CTACATGGTCTTCCGCTTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCTGAGCACCGT
CATCTTGAATGTGGAATGGGTGCCTACCCGGATGCGGGCCATCATGTCGACAGCACTCGG
GTACTGCTACACCTTTGGCCAGTTCATTCTGCCCGGCCTGGCCTACGCCATCCCCCAGTG
GCGTTGGCTGCAGTTAACTGTGTCCATTCCCTTCTTCGTCTTCTTCCTATCATCCTGGTG
GACACCAGAGTCCATACGCTGGTTGGTCTTGTCTGGAAAGTCCTCGAAGGCCCTGAAGAT
ACTCCGGCGGGTGGCTGTCTTCAATGGCAAGAAGGAAGAGGGAGAAAGGCTCAGCTTGGA
GGAGCTCAAACTCAACCTGCAGAAGGAGATCTCCTTGGCCAAGGCCAAGTACACCGCAAG
TGACCTGTTCCGGATACCCATGCTGCGCCGCATGACCTTCTGTCTTTCCCTGGCCTGGTT
TGCTACCGGTTTTGCCTACTATAGTTTGGCTATGGGTGTGGAAGAATTTGGAGTCAACCT
CTACATCCTCCAGATCATCTTTGGTGGGGTCGATGTCCCAGCCAAGTTCATCACCATCCT
CTCCTTAAGCTACCTGGGCCGGCATACCACTCAGGCCGCTGCCCTGCTCCTGGCAGGAGG
GGCCATCTTGGCTCTCACCTTTGTGCCCTTGGACTTGCAGACCGTGAGGACAGTATTGGC
TGTGTTTGGGAAGGGATGCCTATCCAGCTCCTTCAGCTGCCTCTTCCTCTACACAAGTGA
ATTATACCCCACAGTCATCAGGCAAACAGGTATGGGCGTAAGTAACCTGTGGACCCGCGT
GGGAAGCATGGTGTCCCCGCTGGTGAAAATCACGGGTGAGGTACAGCCCTTCATCCCCAA
TATCATCTACGGGATCACCGCCCTCCTCGGGGGCAGTGCTGCCCTCTTCCTGCCTGAGAC
CCTGAATCAGCCCTTGCCAGAGACTATCGAAGACCTGGAAAACTGGTCCCTGCGGGCAAA
GAAGCCAAAGCAGGAGCCAGAGGTGGAAAAGGCCTCCCAGAGGATCCCTCTACAGCCTCA
CGGACCAGGCCTGGGCTCCAGCTGAGGACAACGGAACCCCCTTTCCCTGCCCTCCAGAGA
CTGATCCTAGCCAGGCACCTTAGGAGTATAGGGAGGCCCCATATAGGTCCATCCTCCTAG
GATGAAGCCTTCTGAGAGCTTGGTGAAGGTGTCTCCATCACCACCACCAGAGCCTCCTGC
CCAGCCCTGGCCAGTTCAAAGTTTCAGCCATCCCTGCCCTTGTTCTCCCTGCAACCCAGG
CCCTGCCATTCTTCTGTCTAGCCCTTCCCCACTGGCCACCTTCCCCCACTGTCCCGGTCC
TCTTCCCCTGAGGTCCCCTGATATCCCCTGGCTCAGTCCTAACAAGACTGAGTCTTAACA
AGATGAGAAGTCCTCCCCTTCTTGCCTCCCACACTTTTCTTTGATGGGAGGTTTCAATAA
ACAGCGATAAGAACTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
5' Read Nucleotide Sequence
>OriGene 5' read for NM_004254 unedited
NNGGGAGTTCAGAATTTGTAATACGACTCACTATNAGGGCGGCCGCGNAATTCGCCATTA
CGGCCGGGGAGCTTGTTAGAGCTGAGCTGCCCTACTACAGCAGCTGCCGGCCCCTAGGAC
AGAGCAGGGACCTCAACTACACTGATCACCAGCCCCATCGGATCCAGACCCGGCCACCAG
CTCTGGCTCGTCTTGCCCCAGTGCCATGACCTTCTCGGAGATCCTGGACCGTGTGGGAAG
CATGGGCCATTTCCAGTTCCTGCATGTAGCCATACTGGGCCTCCCGATCCTCAACATGGC
CAACCACAACCTGCTGCAGATCTTCACAGCCGCCACCCCTGTCCACCACTGTCGCCCGCC
CCACAATGCCTCCACAGGGCCTTGGGTGCTCCCCATGGGCCCAAATGGGAAGCCTGAGAG
GTGCCTCCGTTTTGTACATCCGCCCAATGCCAGCCTGCCCAATGACACCCAGAGGGCCAT
GGAGCCATGCCTGGATGGCTGGGTCTACAACAGCACCAAGGACTCCATTGTGACAGAGTG
GGACTTGGTGTGCAACTCCAACAAACTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGG
TATACTGATTGGAGGGCTCGTGCTTGGAGACCTGTCTGACAGGTTTGGCCGCAGGCCCAT
CCTGACCTGCAGCTACCTGCTGCTGGCAGCCAGCGGCTCCGGTGCAGCCTTCAGCCCCAC
CTTCCCCATCTACATGGTCTTCCGCTTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCT
GAGCACCGTCATCTTTGATGTGGAATGGGTGCCTACCCGGATGCGGGCCATCATGTCGAC
AGCACTCGGGTACTGCTACACCTTTGGCCAGTTCATTCTGNCCGGNCTGGCCTACNGCAT
TCCCCATGGCGTTGGC
Restriction Sites Please inquire |
ACCN NM_004254
Insert Size 2200 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_004254.2, NP_004245.2
RefSeq Size 2207 bp
RefSeq ORF 1629 bp
Locus ID 9376
UniProt ID Q8TCC7
Cytogenetics 11q12.3
Protein Families Transmembrane
Summary This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. provided by RefSeq, May 2010
Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform 1).
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Documents
Resources
"NM_004254" in other vectors (6)
SKU Description Size Price
RC205056 SLC22A8 (Myc-DDK-tagged)-Human solute carrier family 22 (organic anion transporter), member 8 (SLC22A8), transcript variant 1 10 ug
$757.00
RC205056L1 Lenti ORF clone of Human solute carrier family 22 (organic anion transporter), member 8 (SLC22A8), transcript variant 1, Myc-DDK-tagged 10 ug
$1,057.00
RC205056L2 Lenti ORF clone of Human solute carrier family 22 (organic anion transporter), member 8 (SLC22A8), transcript variant 1, mGFP tagged 10 ug
$1,057.00
RC205056L3 Lenti ORF clone of Human solute carrier family 22 (organic anion transporter), member 8 (SLC22A8), transcript variant 1, Myc-DDK-tagged 10 ug
$1,057.00
RC205056L4 Lenti ORF clone of Human solute carrier family 22 (organic anion transporter), member 8 (SLC22A8), transcript variant 1, mGFP tagged 10 ug
$1,057.00
RG205056 SLC22A8 (tGFP-tagged) - Human solute carrier family 22 (organic anion transporter), member 8 (SLC22A8), transcript variant 1 10 ug
$957.00

file-alt Citations

Potential Interaction of Pinocembrin with Drug Transporters and Hepatic Drug-Metabolizing Enzymes
Sangkapat, Boonnop, Pimta et al
Pharmaceuticals (2025) 18 (1), 42-42 DOI: 10.3390/ph18010042
Cited by 2
AI Summary: OriGene products, specifically the hOAT1 expression plasmid (#SC303532), hOAT3 expression plasmid (#SC122673), and the pCMV6 vector, were used to generate cell lines overexpressing human OAT1 and OAT3, enabling the study of pinocembrin’s interactions with these drug transporters.
Snippet: ells overexpressing hOAT1 (hOAT1-MDCK) and hOAT3 (OAT3-MDCK), the parent MDCK cells were transfected with the expression plasmids of hOAT1 (# SC303532) or hOAT3 (# SC122673) or an empty pCMV6 vector (OriGene Technologies, Inc., Rockville, MD, USA). After transfection, the hOAT1-MDCK and hOAT3-MDCK cells were selected by complete MEM containing 700 µg/mL G418 for eight weeks. The Chinese hamster o
Estrone sulphate uptake by the microvillous membrane of placental syncytiotrophoblast is coupled to glutamate efflux
Lofthouse, Cleal, O'Kelly et al
Biochem. Biophys. Res. Commun. (2018)
AI Summary: OriGene contributed plasmids containing the cDNAs of human SLC22A6 (OAT1), SLC22A8 (OAT3), SLC22A9 (OAT7), SLC02A1 (OATP2A1), SLC02B1 (OATP2B1), and SLC04A1 (OATP4A1), which were used to overexpress these transporters in Xenopus oocytes for functional studies in the paper.
Snippet: Plasmids containing the cDNA of human SLC22A6 (OAT1), SLC22A8 (OAT3), SLC22A9 (OAT7), SLC02A1 (OATP2A1), SLC02B1 (OATP2B1), and SLC04A1 (OATP4A1) obtained from Origene (Origene, USA) were linearized using restriction enzymes (Promega
Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir
Stray, Bam, Birkus et al
Antimicrob. Agents Chemother. (2013) 57 (10), 4982-9 DOI: 10.1128/AAC.00712-13
AI Summary: OriGene contributed to this study by providing the MRP4 (SC121947) cDNA construct, which was used to transiently transfect HEK293T cells for evaluating the effect of cobicistat on tenofovir transport by renal anion transporters.
Snippet: and MRP4 (SC121947) were obtained from Origene (Rockville, MD). HEK293T cells were seeded in 6-well plates 24 h prior to transfection. Subconfluent cells were transiently transfected with the above cDNA constructs using Lipofectamine 2000 (Life Technologies, Carlsbad
Carrier-mediated transport of quercetin conjugates: involvement of organic anion transporters and organic anion transporting polypeptides
Wong, Akiyama, Abe et al
Biochem. Pharmacol. (2012) 84 (4), 564-70 DOI: 10.1016/j.bcp.2012.05.011
Cited by 50
AI Summary: OriGene contributed OAT2 and OAT4 expression plasmids, which were used to generate HEK293 cells expressing these transporters for functional studies of quercetin conjugate uptake.
Snippet: accession number: NM_004254) and OAT4 (Genebank accession number: NM_018484.2) expression plasmids were obtained from Origene (Rockville, MD ... and significant expression of OAT2 and OAT4, but low expression of OATP1B1 (data not shown), in good agreement with
Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)
Wong, Botting, Orfila et al
Biochem. Pharmacol. (2011) 81 (7), 942-9 DOI: 10.1016/j.bcp.2011.01.004
Cited by 107
AI Summary: OriGene contributed OAT1 (SLC22A6, NM_153276) and OAT3 (SLC22A8, NM_004254) expression plasmids, which were used to generate cells overexpressing these transporters for studying flavonoid conjugate uptake and their effects on drug-induced cytotoxicity.
Snippet: OAT1 (SLC22A6 transcript variant 2, Genebank Accession Number: NM_153276) and OAT3 (SLC22A8 transcript variant 1, Genebank Accession Number: NM_004254) expression plasmids were obtained from Origene (Rockville, MD).
Showing 1-5 of 5 papers.
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