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CDX2 (NM_001265) Human Untagged Clone

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SKU
SC122588
CDX2 (untagged)-Human caudal type homeobox 2 (CDX2)
  $300.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol CDX2
Synonyms CDX-3; CDX2/AS; CDX3
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_001265 edited
GGGACCGCCTCGGAGGCAGAAGAGCCGCGAGGAGCCAGCGGAGCACCGCGGGCTGGGGCG
CAGCCACCCGCCGCTCCTCGAGTCCCCTCGCCCCTTTCCCTTCGTGCCCCCCGGCAGCCT
CCAGCGTCGGTCCCCAGGCAGCATGGTGAGGTCTGCTCCCGGACCCTCGCCACCATGTAC
GTGAGCTACCTCCTGGACAAGGACGTGAGCATGTACCCTAGCTCCGTGCGCCACTCTGGC
GGCCTCAACCTGGCGCCGCAGAACTTCGTCAGCCCCCCGCAGTACCCGGACTACGGCGGT
TACCACGTGGCGGCCGCAGCTGCAGCGGCAGCGAACTTGGACAGCGCGCAGTCCCCGGGG
CCATCCTGGCCGGCAGCGTATGGCGCCCCACTCCGGGAGGACTGGAATGGCTACGCGCCC
GGAGGCGCCGCGGCCGCCGCCAACGCCGTGGCTCACGGCCTCAACGGTGGCTCCCCGGCC
GCAGCCATGGGCTACAGCAGCCCCGCAGACTACCATCCGCACCACCACCCGCATCACCAC
CCGCACCACCCGGCCGCCGCGCCTTCCTGCGCTTCTGGGCTGCTGCAAACGCTCAACCCC
GGCCCTCCTGGGCCCGCCGCCACCGCTGCCGCCGAGCAGCTGTCTCCCGGCGGCCAGCGG
CGGAACCTGTGCGAGTGGATGCGGAAGCCGGCGCAGCAGTCCCTCGGCAGCCAAGTGAAA
ACCAGGACGAAAGACAAATATCGAGTGGTGTACACGGACCACCAGCGGCTGGAGCTGGAG
AAGGAGTTTCACTACAGTCGCTACATCACCATCCGGAGGAAAGCCGAGCTAGCCGCCACG
CTGGGGCTCTCTGAGAGGCAGGTTAAAATCTGGTTTCAGAACCGCAGAGCAAAGGAGAGG
AAAATCAACAAGAAGAAGTTGCAGCAGCAACAGCAGCAGCAGCCACCACAGCCGCCTCCG
CCGCCACCACAGCCTCCCCAGCCTCAGCCAGGTCCTCTGAGAAGTGTCCCAGAGCCCTTG
AGTCCGGTGTCTTCCCTGCAAGCCTCAGTGTCTGGCTCTGTCCCTGGGGTTCTGGGGCCA
ACTGGGGGGGTGCTAAACCCCACCGTCACCCAGTGACCCACCGGGGTCTGCAGCGGCAGA
GCAATTCCAGGCTGAGCCATGAGGAGCGTGGACTCTGCTAGACTCCTCAGGAGAGACCCC
TCCCCTCCCACCCACAGCCATAGACCTACAGACCTGGCTCTCAGAGGAAAAATGGGAGCC
AGGAGTAAGACAAGTGGGATTTGGGGCCTCAAGAAATATACTCTCCCAGATTTTTACTTT
TTCCCATCTGGCTTTTTCTGCCACTGAGGAGACAGAAAGCCTCCGCTGGGCTTCATTCCG
GACTGGCAGAAGCATTGCCTGGACTGACCACACCAACCAGGCCTTCATCCTCCTCCCCAG
CTCTTCTCTTCCTAGATCTGCAGGCTACACCTCTGGCTAGAGCCGAGGGGAGAGAGGGAC
TCAAGGGAAAGGCAAGCTTGAGGCCAAGATGGCTGCTGCCTGCTCATGGCCCTCGGAGGT
CCAGCTGGGCCTCCTGCCTCCGGGCAGGCAAGGTTTACACTGCGGAAGCCAAAGGCAGCT
AAGATAGAAAGCTGGACTGACCAAAGACTGCAGAACCCCCAGGTGGCCTGCGTCTTTTTT
CTCTTCCCTTCCCAGACCAGGAAAGGCTTGGCTGGTGTATGCACAGGGTGTGGTATGAGG
GGGTGGTTATTGGACTCCAGGCCTGACCAGGGGGCCCGAACAGGGACTTGTTTAGAGAGC
CTGTCACCAGAGCTTCTCTGGGCTGAATGTATGTCAGTGCTATAAATGCCAGAGCCAACC
TGGACTTCCTGTCATTTTCACAATCTTGGGGCTGATGAAGAAGGGGGTGGGGGGAGTTTG
TGTTGTTGTTGCTGCTGTTTGGGTTGTTGGTCTGTGTAACATCCAAGCCAGAGTTTTTAA
AGCCTTCTGGATCCATGGGGGGAGAAGTGATATGGTGAAGGGAAGTGGGGAGTATTTGAA
CACAGTTGAATTTTTTCTAAAAAGAAAAAGAGATAAATGAGCTTTCCAGAAAAAAAAAAA
AAAAAAAA
5' Read Nucleotide Sequence
>OriGene 5' read for NM_001265 unedited
TTGAAGACGTCGGTATTGTATACGACTCACTAAGGCGGCCGCGNAATTCGCACGGGGGGA
CCGCCTCGGNAGCAGAAGAGCCGCGAGGAGCCAGCGGAGCACCGCGGGCTGGGGCGCAGC
CACCCGCCGCTCCTCGAGTCCCCTCGCCCCTTTCCCTTCGTGCCCCCCGGCAGCCTCCAG
CGTCGGTCCCCAGGCAGCATGGTGAGGTCTGCTCCCGGACCCTCGCCACCATGTACGTGA
GCTACCTCCTGGACAAGGACGTGAGCATGTACCCTAGCTCCGTGCGCCACTCTGGCGGCC
TCAACCTGGCGCCGCAGAACTTCGTCAGCCCCCCGCAGTACCCGGACTACGGCGGTTACC
ACGTGGCGGCCGCAGCTGCAGCGGCAGCGAACTTGGACAGCGCGCAGTCCCCGGGGCCAT
CCTGGCCGGCAGCGTATGGCGCCCCACTCCGGGAGGACTGGAATGGCTACGCGCCCGGAG
GCGCCGCGGCCGCCGCCAACGCCGTGGCTCACGGCCTCAACGGTGGCTCCCCGGCCGCAG
CCATGGGCTACAGCAGCCCCGCAGACTACCATCCGCACCACCACCCGCATCACCACCCGC
ACCACCCGGCCGCCGCGCCTTCCTGCGCTTCTGGGCTGCTGCAAACGCTCAACCCCGGCC
CTCCTGGGCCCGCCGCCACCGCTGCCGCCGAGCAGCTGTCTCCCGGCGGCCAGCGGCGGA
ACCTGTGCGAGTGGATGCGGAAGCCGGCGCAGCAGTCCCTCGGCAGCCAAGTGAAAACCA
GGACGAAAGACAATATCGAGTGGTGTACACGGACCACCAGCGGCTGGAGCTGGAGAAGGA
GTTTCACTACAGTCGCTACATCACCATCCGTAGGAAAGCCGAG
Restriction Sites Please inquire |
ACCN NM_001265
Insert Size 2108 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001265.2, NP_001256.1
RefSeq Size 2108 bp
RefSeq ORF 942 bp
Locus ID 1045
UniProt ID Q99626
Cytogenetics 13q12.2
Protein Families Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transcription Factors
Summary This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. provided by RefSeq, Jan 2012
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Documents
Resources
"NM_001265" in other vectors (6)
SKU Description Size Price
RC204883 CDX2 (Myc-DDK-tagged)-Human caudal type homeobox 2 (CDX2) 10 ug
$300.00
RC204883L1 Lenti ORF clone of Human caudal type homeobox 2 (CDX2), Myc-DDK-tagged 10 ug
$600.00
RC204883L2 Lenti ORF clone of Human caudal type homeobox 2 (CDX2), mGFP tagged 10 ug
$600.00
RC204883L3 Lenti ORF clone of Human caudal type homeobox 2 (CDX2), Myc-DDK-tagged 10 ug
$600.00
RC204883L4 Lenti ORF clone of Human caudal type homeobox 2 (CDX2), mGFP tagged 10 ug
$600.00
RG204883 CDX2 (tGFP-tagged) - Human caudal type homeobox 2 (CDX2) 10 ug
$489.00 $500.00

file-alt Citations

Cancer-associated fibroblast-derived exosomal microRNA-24-3p enhances colon cancer cell resistance to MTX by down-regulating CDX2/HEPH axis
Zhang, Shi, Liu et al
J Cell Mol Med (2021)
Cited by 69
AI Summary: OriGene products pCMV6-XL5-CDX2 and pCMV6-XL5-HEPH expression plasmids were used to overexpress CDX2 and HEPH in colon cancer cells, enabling the study to investigate how these genes impact methotrexate resistance mediated by exosomal miR-24-3p.
Snippet: After 18 hours, expres- sion plasmids pCMV6-XL5-CDX2 (CDX2) and pCMV6-XL5-HEPH (HEPH) (OriGene Technologies, Rockville, MD, USA) and small inter- fering RNAs (siRNA) targeting CDX2 (si-CDX2) and HEPH (si-HEPH) were used for transfection, which;- After 18 hours, expres- sion plasmids pCMV6-XL5-CDX2 (CDX2) and pCMV6-XL5-HEPH (HEPH) (OriGene Technologies, Rockville, MD, USA) and small inter- fering RNAs (siRNA) targeting CDX2 (si-CDX2) and HEPH (si-HEPH) were used for transfection, which
Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition
Sakuma, Aoki, Kannagi
Proc Natl Acad Sci U S A (2012) 109 (20), 7776-81 DOI: 10.1073/pnas.1111135109
Cited by 168
AI Summary: In this study, OriGene products were used for gene knockdown and overexpression experiments, specifically employing OriGene’s c-Myc shRNA plasmid and CDX2 cDNA clone, to demonstrate the roles of c-Myc and CDX2 in regulating E-selectin ligand expression during EMT in colon cancer cells.
Showing 1-2 of 2 papers.
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