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KCTD11 (NM_001002914) Human Untagged Clone

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SKU
SC121957
KCTD11 (untagged)-Human potassium channel tetramerisation domain containing 11 (KCTD11)
  $300.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol KCTD11
Synonyms C17orf36; KCASH1; REN; REN/KCTD11
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC121957 sequence for NM_001002914 edited (data generated by NextGen Sequencing)
ATGCTGGGGGCCATGTTTAGGGCCGGCACCCCCATGCCCCCCAACCTCAATTCCCAAGGA
GGCGGCCACTACTTCATCGACCGGGATGGCAAGGCCTTCCGGCACATCCTCAATTTCCTG
AGGCTGGGCCGCCTGGACCTGCCCCGTGGGTACGGAGAGACAGCGCTGCTCAGGGCAGAG
GCTGACTTCTACCAGATCCGGCCCCTCCTGGATGCGCTGCGGGAACTGGAGGCCTCTCAG
GGGACCCCTGCACCCACAGCTGCCCTGCTCCACGCAGATGTAGATGTCAGCCCCCGCCTG
GTGCACTTCTCTGCTCGCCGGGGACCCCATCACTATGAGCTGAGCTCCGTCCAGGTGGAC
ACCTTCCGAGCCAACCTTTTCTGCACCGACTCTGAGTGTCTAGGTGCTTTGCGGGCCCGA
TTTGGTGTGGCCAGTGGGGATAGGGCAGAGGGGAGCCCACATTTTCATCTGGAGTGGGCC
CCCCGCCCCGTGGAACTCCCCGAGGTGGAGTATGGGAGACTGGGGCTGCAGCCGCTGTGG
ACTGGGGGGCCAGGAGAGCGGCGGGAGGTGGTGGGCACCCCAAGCTTCCTGGAGGAGGTG
CTGCGGGTGGCTCTCGAGCACGGCTTCCGACTAGACTCTGTCTTCCCCGACCCCGAAGAC
CTGCTCAACTCCAGGTCTCTGCGCTTTGTCCGGCACTGA

Clone variation with respect to NM_001002914.2
213 c=>t
5' Read Nucleotide Sequence
>OriGene 5' read for NM_001002914 unedited
CCCCCCATTCCCCCGCCCGTTGACGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTAT
ATAAGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCG
GCCGCGAATTCGGCACGAGGGTCTCTTAAAGGGCCCCGGGCCGCTGCCCTTAGGCCACTT
CCTGGGGGCGGAGAGGACCTCAGCGGCTGCGGCGACACCCAGGGAAGGCGGCGCGGCCGG
GTCCCGAAACTCCTGGCTGTTTCCATCAGAGCCCTCGGACACTCCCAGCCCGGGCTGAGC
ACGCATCGTCGCTCCCCGGCGGATACAAGGGGGCTCCGCCATCCGCTCCCGTCAGTTCGG
CCTCCATCTCCTGGGACCCGCGCCGGCAGCCAGGCCAGGCCTCTGAGTGGCCCCAGAGCC
CTGGCTGGACTCGTCCACGGCGGCAGCGATCTGCCCGGGGTCTCGGAGGCCATCCCTTCA
GAGTCGGCCCTGTGCTCGCCACCGTCACCTGCTGGTTGGATTCCGGAAACCCACTGTCTG
AAGACCACAGAGGGGTGTCGCTGACCACCCCAAATCGGATACGTCCAGACCTCAAGCTCC
CTTCCCCTCTCTGGCTGCCCTCTGCTCTTTTCATCTCTTCTCTCAACCTTTTGGGGATTT
CTGTGTCCTGACACCACCTCCCCATCCACCACCAAAGTAGCCGGGGGTGAGCCCCAAACC
TTACTGGNGTGTGCTCCACCTGTGCCTCCAACCCAGCGAATCTGACAGCTTCGACCCAAT
TCTGCCCACACCCAGAAAGTTCTGCCTTTTCTTTTCTTTTCGGNGNCTCCTGTACTTCCC
AAAATTCTCCTCCTCCTGTGCCCTCTTCGCCCCCTCCTATTGGGGCCCCGTGACCCTGCA
TGTTGGGGGGCAC
3' Read Nucleotide Sequence
>OriGene 3' read for NM_001002914 unedited
NNNCCGTTCTACTATGNACGCGGCCGCATTCTAGNGATCGGTTTTTTTTTTTTTTTTTTG
TGGTTCCAAAAGCAGTTTTATTTTTCTTCTTGTAAATCATGACCAGTGAGAAATAATGTG
TGCCCCACCCCCCACCAGTGAAGAAGCTGTGCGTGAGTATCCCACCCGCTCTGGGACCCA
GAAATCCCATCCCTTCCCATCTCCTCCCCCACTGTCCCAAACTCTTCGTCTCCTCTCTCT
GCCCTGGGCGGGCTTGGGCCTTCCCCAGCTATCTCCTAGCAACAGGTCCATGGTTGCCTC
AGCAACCAAGAGTTCCATACAGGCCTCAGAGGCCCAGCTAAGCCCAGTGACTTCTCTTAC
CTCTCACCAGGAAGATCCCAGTGACTCAAACCCCAACAGGCCCCTCCTGGCTACGTGGTG
ATGCATATACATGCGTGCACATAAACACACACACACACACACACACACACACACACACCC
TGTGATTAAACTACTAATTGTCAACCACCTCACAGGTATACCACAGACACACCCTGTGCC
AAAAGAGTCGCTTGGGAACCCCAAACAGGCCTGGACATGCGGACATCACAGACCCTGTGG
TCAGCAACACAGATATGAACCCGGGTGCCCCGGGCCTATTCATCATTCAGCCTCACGGGG
TGGTTTTCCCGCGCACCTGGAAAAAGGGCCGGACCCCCAGATACTACCCTTTTTCCCTGG
GCAACCTGGCCATAGTTGGGAATTTTTCCAGAGAAGGGAGGTTCCAACCCCTTGGCATGG
GGACTGGCCAACTCCCTTAATAAACCAAGGGGGGGGGGGGGCTTTTGCCCCCCCCAGGGA
GGGTGGGGAAAATA
Restriction Sites NotI-NotI |
ACCN NM_001002914
Insert Size 3000 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001002914.1, NP_001002914.1
RefSeq Size 2780 bp
RefSeq ORF 699 bp
Locus ID 147040
UniProt ID Q693B1
Cytogenetics 17p13.1
Protein Families Ion Channels: Other
Summary Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.UniProtKB/Swiss-Prot Function
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"NM_001002914" in other vectors (6)
SKU Description Size Price
RC205782 KCTD11 (Myc-DDK-tagged)-Human potassium channel tetramerisation domain containing 11 (KCTD11) 10 ug
$300.00
RC205782L1 Lenti ORF clone of Human potassium channel tetramerisation domain containing 11 (KCTD11), Myc-DDK-tagged 10 ug
$600.00
RC205782L2 Lenti ORF clone of Human potassium channel tetramerisation domain containing 11 (KCTD11), mGFP tagged 10 ug
$600.00
RC205782L3 Lenti ORF clone of Human potassium channel tetramerisation domain containing 11 (KCTD11), Myc-DDK-tagged 10 ug
$600.00
RC205782L4 Lenti ORF clone of Human potassium channel tetramerisation domain containing 11 (KCTD11), mGFP tagged 10 ug
$600.00
RG205782 KCTD11 (tGFP-tagged) - Human potassium channel tetramerisation domain containing 11 (KCTD11) 10 ug
$489.00 $500.00

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