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MCFD2 (NM_139279) Human Untagged Clone

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SKU
SC120717
MCFD2 (untagged)-Human multiple coagulation factor deficiency 2 (MCFD2), transcript variant 1
  $150.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol MCFD2
Synonyms F5F8D; F5F8D2; LMAN1IP; SDNSF
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF sequence for NM_139279 edited
ATGACCATGAGATCCCTGCTCAGAACCCCCTTCCTGTGTGGCCTGCTCTGGGCCTTTTGT
GCCCCAGGCGCCAGGGCTGAGGAGCCTGCAGCCAGCTTCTCCCAACCCGGCAGCATGGGC
CTGGATAAGAACACAGTGCACGACCAAGAGCATATCATGGAGCATCTAGAAGGTGTCATC
AACAAACCAGAGGCGGAGATGTCGCCACAAGAATTGCAGCTCCATTACTTCAAAATGCAT
GATTATGATGGCAATAATTTGCTTGATGGCTTAGAACTCTCCACAGCCATCACTCATGTC
CATAAGGAGGAAGGGAGTGAACAGGCACCACTAATGAGTGAAGATGAACTGATTAACATA
ATAGATGGTGTTTTGAGAGATGATGACAAGAACAATGATGGATACATTGACTATGCTGAA
TTTGCAAAATCACTGCAGTAG
5' Read Nucleotide Sequence
>OriGene 5' read for NM_139279 unedited
TTCAAATTTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGGGGCTGG
TGAGGCTCACGTTGGAGGGCTTCGCGTCTGCTTCGGAGACCGTAAGGATATTGATGACCA
TGAGATCCCTGCTCAGAACCCCCTTCCTGTGTGGCCTGCTCTGGGCCTTTTGTGCCCCAG
GCGCCAGGGCTGAGGAGCCTGCAGCCAGCTTCTCCCAACCCGGCAGCATGGGCCTGGATA
AGAACACAGTGCACGACCAAGAGCATATCATGGAGCATCTAGAAGGTGTCATCAACAAAC
CAGAGGCGGAGATGTCGCCACAAGAATTGCAGCTCCATTACTTCAAAATGCATGATTATG
ATGGCAATAATTTGCTTGATGGCTTAGAACTCTCCACAGCCATCACTCATGTCCATAAGG
AGGAAGGGAGTGAACAGGCACCACTAATGAGTGAAGATGAACTGATTAACATAATAGATG
GTGTTTTGAGAGATGATGACAAGAACAATGATGGATACATTGACTATGCTGAATTTGCAA
AATCACTGCAGTAGATGTTATTTGGCCATCTCCTGGTTATATACAAATGTGACCCGTGAT
AATGTGATTGAACACTTTAGTAATGCAAAATAACTCATTTCCAACTACTGCTGCAGCATT
TTGGTAAAAACCTGTAGCGATTCGTTACACTGGGGTGAGAAGAGATAAGAGAAATGAAAG
AGAAGAGAAATGGGACATCTAATAGTCCCTAAGTGCTATTAAATACCTTATTGGACAANG
GCTTGCTTCAGCATCTGTATTAGTCTGTATTAATGCTGCTGATAAAGACGTACCCGAGAC
TGGGAAGAAAAAGAAGTTTACTTGGACCTACAGTTNCACATGGCTGGNGGAGGCCTCAAA
TCATGGGCGGGAGGGAAAGGCACTTCTTACATGGNCAGCAGAAAAATGAGGAAGAAACAA
AGGGGAAACCCCTGAA
3' Read Nucleotide Sequence
>OriGene 3' read for NM_139279 unedited
GGTTTGNNNNNAATTCACTNTGNACCGNCGGCCGCATNCTGANGATCGATTTTTTTTTTT
TTTTTTTTGCTTCATCAGTTTTATTGGTCATATATCCAGNAATCATCATATATAAATCTT
TCAAAATAATGAGCTATTACAAGAATAGTTTACAAGTCAGCTCTGACTGCACAAATACTT
GACACAGGAAACCATTTTTACNAATACATATGTTTTCTTATAATACTGTNATAAAGAAAA
ATAAGTCTGTATACATCCTAACGACAAATTTTGTAGTCTCTTTTTCCCATTCAATCATCG
TTTCAAGGTTTCTAATACCGAACGTTCCTCCCATCCCATAAACCAATTTCAAACTGGCGG
CGTCTTTCATTTTCCAAACCCTAAAGAATTCACCGGGGAAAGGGGTTTTGGGGTCCCCTT
TTAAACTTCCCGAATTGAAAAAAAACCCGTGTCTTGGGCAAAAAAAGGGAAATTCAAACA
ATTCCCCCTGGAAGAAAAATCCATCGGAGAAAAAAATGGGTGGGGAAAAAATTTTTTACT
TCCCCCTAGGCAAGGCCCGGGGGGGGTTTTACCCCCCCGGGGAAAAAACCCGGCCATCCC
CAAAGATTGCCCACCAGGGGGGAAAAAAACCCCCCCCAACCCCGGGGGTAAAAAAGAAAA
AGCTGCCCCCCCCCTGGTTTGGGGAAACCACACCCCCTTTTGGGGGGGGCCCCCCCGGGG
GAGAGAAAAACAACAACCCCCCCCCCTTTTTTGGGGGGGGGGGGCGCCTTTTTTTTAAAA
ACCCCGCAAACGCGGGGGGAGGGGGCCCTTTTCTCCCCGCCGGTGGGTGTTTTCTTCCAA
GGGGGGGGGGGAGAGGAAAACTTTTTTCTCCCTGGTGGGTGGGGAGAGAAAC
Restriction Sites NotI-NotI |
ACCN NM_139279
Insert Size 4700 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_139279.3, NP_644808.1
RefSeq Size 4144 bp
RefSeq ORF 441 bp
Locus ID 90411
UniProt ID Q8NI22
Cytogenetics 2p21
Summary This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Apr 2016
Transcript Variant: This variant (1) encodes isoform A. Variants 1, 2, 3 and 4 encode the same isoform (A).
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Documents
Resources
"NM_139279" in other vectors (6)
SKU Description Size Price
RC202230 MCFD2 (Myc-DDK-tagged)-Human multiple coagulation factor deficiency 2 (MCFD2), transcript variant 1 10 ug
$150.00
RC202230L1 Lenti ORF clone of Human multiple coagulation factor deficiency 2 (MCFD2), transcript variant 1, Myc-DDK-tagged 10 ug
$450.00
RC202230L2 Lenti ORF clone of Human multiple coagulation factor deficiency 2 (MCFD2), transcript variant 1, mGFP tagged 10 ug
$450.00
RC202230L3 Lenti ORF clone of Human multiple coagulation factor deficiency 2 (MCFD2), transcript variant 1, Myc-DDK-tagged 10 ug
$450.00
RC202230L4 Lenti ORF clone of Human multiple coagulation factor deficiency 2 (MCFD2), transcript variant 1, mGFP tagged 10 ug
$450.00
RG202230 MCFD2 (tGFP-tagged) - Human multiple coagulation factor deficiency 2 (MCFD2), transcript variant 1 10 ug
$489.00

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