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Lipoprotein lipase (LPL) (NM_000237) Human Untagged Clone

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SKU
SC120026
LPL (untagged)-Human lipoprotein lipase (LPL)
  $457.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol Lipoprotein lipase
Synonyms HDLCQ11; LIPD
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC120026 sequence for NM_000237 edited (data generated by NextGen Sequencing)
ATGGAGAGCAAAGCCCTGCTCGTGCTGACTCTGGCCGTGTGGCTCCAGAGTCTGACCGCC
TCCCGCGGAGGGGTGGCCGCCGCCGACCAAAGAAGAGATTTTATCGACATCGAAAGTAAA
TTTGCCCTAAGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTA
GCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTCATGGTGATCCAT
GGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTAC
AAGAGAGAACCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCAT
TACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCCCGGTTTATCAAC
TGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTT
GGAGCCCATGCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACT
GGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGTCGTCTTTCTCCT
GATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGC
ATTGGAATCCAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAG
CCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGACTTGGAGATGTG
GACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTG
AATGAAGAAAATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGG
CTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAGATCAATAAAGTC
AGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTC
TTCCATTACCAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAG
GCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATCCCATTCACTCTG
CCTGAAGTTTCCACAAATAAGACATACTCCTTCCTAATTTACACAGAGGTAGATATTGGA
GAACTACTCATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGG
TGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGAGAGACTCAGAAA
AAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCG
GTATTTGTGAAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGA

Clone variation with respect to NM_000237.2
1164 c=>a
5' Read Nucleotide Sequence
>OriGene 5' read for NM_000237 unedited
TTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGTCCCCCTCTTCCT
CCTCCTCAAGGGAAAGCTGCCCACTTCTAGCTGCCCTGCCATCCCCTTTAAAGGGCGACT
TGCTCAGCGCCAAACCGCGGCTCCAGCCCTCTCCAGCCTCCGGCTCAGCCGGCTCATCAG
TCGGTCCGCGCCTTGCAGCTCCTCCAGAGGGACGCGCCCCGAGATGGAGAGCAAAGCCCT
GCTCGTGCTGACTCTGGCCGTGTGGCTCCAGAGTCTGACCGCCTCCCGCGGAGGGGTGGC
CGCCGCCGACCAAAGAAGAGATTTTATCGACATCGAAAGTAAATTTGCCCTAAGGACCCG
TGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTAC
CTGTCATTTCAATCACAGCAGCAAAACCTTCATGGTGATCCATGGCTGGACGGTAACAGG
AATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAAGAGAGAACCAGACTC
CAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGG
CTACACCAAACTGGTGGGACAGGATGTGGCCCGGTTTATCAACTGGATGGAGGAGGAGTT
TAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGGAGCCCATGCTGCTGG
CATTGCAAGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGG
ACCCTACTTTGAGTATGCAGAAGCCCCGAGTCGTCTTTCTCCTGATGATGCAGATTTGGT
AGACGTCTTACACACTTTCACCAGAGGTCCCCTGGTCGAGCATGGAATCCAGAACN
3' Read Nucleotide Sequence
>OriGene 3' read for NM_000237 unedited
TGGACCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTGGGGGAATAA
AATGTTGTCAATTTTATTAAAAGCTGATTCCATTTCTTCACACAGTTAAGTACGTTTCTT
TCTTGTTTTGTTAAAGCCCATTTCATAAGATTAAGTTGGCTCTGTGAGACCATCACTGAT
AAAGACACATACAGTTAGCACCACACATTTATAAATGCAGATAGCCACAATGACCTTTCC
AATATGTACAAGCTCCATTTACACATCCACACATGTATTTACAGCTAATAAATAAAATGT
AAAGCCAGAACATCCTTGATATATATAGCAAAGTTTTTCGGAGCCAGAGTTCCCAGTGCT
ATGTGCTGCTTTAGTGAATCTTTTAAGTTAATGCACCCTGGGTCACAACCCAAATCCAGA
AATTTAATGAATTAATAAAGGGGATGCCAACAACAAATCATACATCATTTTATTTTTAGA
GAGAATTCATTCCAAGCCTGATGATGTTAATCACAACATTGGTCCTACTATTTATAGGCA
CGATCATCTCTCTCAGAGAAAGGGTCGAAGTTCTGGCACATCAGGAACAATTTCTACTCC
GACATGTTCCAATACATCCCTTGATCGACTGTTTTCCCTTCCGAATTATGCTGAAGGACA
ACACACATGCAGAGCTTTCTAGTATGTGTTCAGATATCACATACTTTCACAGTCGGGTTC
CCAGCTATAGCCTCTGAGAATTTGACATCTTTATCATTTCATATTTATACGTAGAAGAGC
ATTCTGAAAAATAGGAGATCTAGNTTATAAANTAGTGGTCACTCACTCCTGATATAGTGN
TAAAAACAAACAATTACACCCTCATGGTACTNCATCTGGCTCATTGCACGCGATGGTTTA
CAAGCACTGCTTAGGAACCACCCCAGGAACTTTTCCACCTTN
Restriction Sites NotI-NotI |
ACCN NM_000237
Insert Size 3670 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_000237.1, NP_000228.1
RefSeq Size 3549 bp
RefSeq ORF 1428 bp
Locus ID 4023
UniProt ID P06858
Cytogenetics 8p21.3
Domains lipase, PLAT
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Glycerolipid metabolism, PPAR signaling pathway
Summary LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. provided by RefSeq, Jul 2008
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"NM_000237" in other vectors (7)
SKU Description Size Price
RC203766 LPL (Myc-DDK-tagged)-Human lipoprotein lipase (LPL) 10 ug
$289.00 $686.00
RC203766L1 Lenti ORF clone of Human lipoprotein lipase (LPL), Myc-DDK-tagged 10 ug
$986.00
RC203766L2 Lenti ORF clone of Human lipoprotein lipase (LPL), mGFP tagged 10 ug
$986.00
RC203766L3 Lenti ORF clone of Human lipoprotein lipase (LPL), Myc-DDK-tagged 10 ug
$986.00
RC203766L4 Lenti ORF clone of Human lipoprotein lipase (LPL), mGFP tagged 10 ug
$986.00
RG203766 LPL (tGFP-tagged) - Human lipoprotein lipase (LPL) 10 ug
$489.00 $886.00
SC322258 LPL (untagged)-Human lipoprotein lipase (LPL) 10 ug
$457.00

file-alt Citations

Severe hypertriglyceridemia due to two novel loss-of-function lipoprotein lipase gene mutations (C310R/E396V) in a Chinese family associated with recurrent acute pancreatitis
Lun, Sun, Wang et al
Oncotarget (2017) 8 (29), 47741-47754 DOI: 10.18632/oncotarget.17762
Snippet: pCMV6-XL5 vector containing normal human LPL cDNA (Origene, America) was used as a template to generate site-directed mutagenesis
FigureFigureFigure
Over-expression of human lipoprotein lipase in mouse mammary glands leads to reduction of milk triglyceride and delayed growth of suckling pups
Wang, Tong, Li et al
PLoS ONE (2011) 6 (6), e20895 DOI: 10.1371/journal.pone.0020895
Cited by 30
AI Summary: OriGene’s plasmid SC120026, containing human lipoprotein lipase (hLPL) cDNA, was used as the template for PCR amplification to generate transgenic mice in this study.
Snippet: If this is the case, then we need to determine the destination of the TG hydrolysis products (FFA, etc). ... Generation of Transgenic Mice. hLPL cDNA was amplified from a plasmid SC120026 (Origene, MD) by PCR, with Xho I restriction sites added at the 5′ end of both primers.
FigureFigureFigure
A novel fluorogenic substrate for the measurement of endothelial lipase activity
Darrow, Olson, Xin et al
J. Lipid Res. (2011) 52 (2), 374-82 DOI: 10.1194/jlr.D007971
Cited by 5
AI Summary: OriGene products contributed to this study by providing the human HL (LIPC, NM_000236) and human LPL (NM_000237) genes from the TrueClone™ collection, which were used to express and characterize the activity of different lipases with the novel fluorogenic substrate.
Snippet: 1A), based on our need for a PLA 1 -sensitive substrate for a high-throughput screen for endothelial lipase inhibitors. ... The human HL (hHL) (LIPC [NM_000236]) and human LPL (hLPL) (NM_000237) genes were obtained from OriGene Technologies, TrueClone collection
Showing 1-3 of 3 papers.
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