CD4 (NM_000616) Human Untagged Clone
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | CD4 |
| Synonyms | CD4mut; IMD79; OKT4D |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_000616 |
| Insert Size | 3070 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_000616.2, NP_000607.1 |
| RefSeq Size | 3084 bp |
| RefSeq ORF | 1377 bp |
| Locus ID | 920 |
| UniProt ID | P01730 |
| Cytogenetics | 12p13.31 |
| Domains | ig, IG, IGc2, IGv |
| Protein Families | Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transmembrane |
| Protein Pathways | Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway |
| Summary | This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. provided by RefSeq, May 2020 Transcript Variant: This variant (1) encodes the longest isoform (1) including a signal peptide and a mature peptide. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
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Resources
"NM_000616" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC206453 | CD4 (Myc-DDK-tagged)-Human CD4 molecule (CD4), transcript variant 1 | 10 ug |
$457.00
|
|
| RC206453L1 | Lenti ORF clone of Human CD4 molecule (CD4), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC206453L2 | Lenti ORF clone of Human CD4 molecule (CD4), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RC206453L3 | Lenti ORF clone of Human CD4 molecule (CD4), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC206453L4 | Lenti ORF clone of Human CD4 molecule (CD4), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RG206453 | CD4 (tGFP-tagged) - Human CD4 molecule (CD4), transcript variant 1 | 10 ug |
$489.00
$657.00
|
|
Citations
Structure-function analysis of human immunodeficiency virus type 1 gp120 amino acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc
Ogert, Ba, Hou et al
J Virol (2009) 83 (23), 12151-63 DOI: 10.1128/JVI.01351-09
Ogert, Ba, Hou et al
J Virol (2009) 83 (23), 12151-63 DOI: 10.1128/JVI.01351-09
AI Summary: OriGene products contributed to this study by providing the human CCR5 cDNA (Cat# SC319377) used for generating CCR5 mutants to analyze HIV-1 gp120 resistance mechanisms to vicriviroc.
Structure-function analysis of HIV-1 gp120 amino acid mutations associated with resistance to the CCR5 co-receptor antagonist vicriviroc
Ogert, Ba, Hou et al
J. Virol (2009)
Ogert, Ba, Hou et al
J. Virol (2009)
Showing 1-2 of 2 papers.
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