UGT2B7 (NM_001074) Human Untagged Clone

SKU SC119466

UGT2B7 (untagged)-Human UDP glucuronosyltransferase 2 family, polypeptide B7 (UGT2B7)

Product Data

• Type: Human Untagged Clone
• Target Symbol: UGT2B7
• Synonyms: UDPGT 2B7; UDPGT2B7; UDPGT 2B9; UDPGTh-2; UDPGTH2; UGT2B9
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119466 sequence for NM_001074 edited (data generated by NextGen Sequencing); ATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGCTTTTGCTTTAGCTCT; GGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCATTGGATGAATATAAAG; ACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTACTGGCATCTTCAGCT; TCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAAATTTATCCCACATCT; TTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAGAGATGGTCAGACCTT; CCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATCATGTCAATATTTGGT; GACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAATTTATGAAAAAAGTA; CAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCCTGTAGTGAGCTGCTG; GCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCTCCTGGCTACACTTTT; GAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCTGTTGTTATGTCAGAA; TTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATCTATGTGCTTTACTTT; GACTTTTGGTTCGAAATATTTGACATGAAGAAGTGGGATCAGTTTTATAGTGAAGTTCTA; GGAAGACCCACTACATTATCTGAGACAATGGGGAAAGCTGACGTATGGCTTATTCGAAAC; TCCTGGAATTTTCAGTTTCCATATCCACTCTTACCAAATGTTGATTTTGTTGGAGGACTC; CACTGCAAACCTGCCAAACCCCTGCCTAAGGAAATGGAAGACTTTGTACAGAGCTCTGGA; GAAAATGGTGTTGTGGTGTTTTCTCTGGGGTCAATGGTCAGTAACATGACAGAAGAAAGG; GCCAACGTAATTGCATCAGCCCTGGCCCAGATCCCACAAAAGGTTCTGTGGAGATTTGAT; GGGAATAAACCAGATACCTTAGGTCTCAATACTCGGCTCTACAAGTGGATACCCCAGAAT; GACCTTCTAGGTCATCCAAAGACCAGAGCTTTTATAACTCATGGTGGAGCCAATGGCATC; TACGAGGCAATCTACCATGGGATCCCTATGGTGGGGATTCCATTGTTTGCCGATCAACCT; GATAACATTGCTCACATGAAGGCCAGGGGAGCAGCTGTTAGAGTGGACTTCAACACAATG; TCGAGTACAGACTTGCTGAATGCATTGAAGAGAGTAATTAATGATCCTTCATATAAAGAG; AATGTTATGAAATTATCAAGAATTCAACATGATCAACCAGTGAAGCCCCTGGATCGAGCA; GTCTTCTGGATTGAATTTGTCATGCGCCACAAAGGAGCTAAACACCTTCGGGTTGCAGCC; CACGACCTCACCTGGTTCCAGTACCACTCTTTGGATGTGATTGGGTTCCTGCTGGTCTGT; GTGGCAACTGTGATATTTATCGTCACAAAATGTTGTCTGTTTTGTTTCTGGAAGTTTGCT; AGAAAAGCAAAGAAGGGAAAAAATGATTAG; ; Clone variation with respect to NM_001074.2;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001074 unedited; GTCACAATTGTATACGACTCATATAGGCGGCNCGCGAATTCGCACCAGGNAAAACAAGCA; TTGCATTGCACCAGGATGTCTGTGAAATGGACTTCAGTAATTTTGCTAATACAACTGAGC; TTTTGCTTTAGCTCTGGGAATTGTGGAAAGGTGCTGGTGTGGGCAGCAGAATACAGCCAT; TGGATGAATATAAAGACAATCCTGGATGAGCTTATTCAGAGAGGTCATGAGGTGACTGTA; CTGGCATCTTCAGCTTCCATTCTTTTTGATCCCAACAACTCATCCGCTCTTAAAATTGAA; ATTTATCCCACATCTTTAACTAAAACTGAGTTGGAGAATTTCATCATGCAACAGATTAAG; AGATGGTCAGACCTTCCAAAAGATACATTTTGGTTATATTTTTCACAAGTACAGGAAATC; ATGTCAATATTTGGTGACATAACTAGAAAGTTCTGTAAAGATGTAGTTTCAAATAAGAAA; TTTATGAAAAAAGTACAAGAGTCAAGATTTGACGTCATTTTTGCAGATGCTATTTTTCCC; TGTAGTGAGCTGCTGGCTGAGCTATTTAACATACCCTTTGTGTACAGTCTCAGCTTCTCT; CCTGGCTACACTTTTGAAAAGCATAGTGGAGGATTTATTTTCCCTCCTTCCTACGTACCT; GTTGTTATGTCAGAATTAACTGATCAAATGACTTTCATGGAGAGGGTAAAAAATATGATC; TATGTGCTTTACTTTGACTTTTGGTTCGAAATATTTGNACATGAAGAGTGGGATCAGTTT; TATAGTGAAGTTCTAGGAAGACCCACTACATTATCTGAGACAATGGGGAAAGCTGACGTA; TGGCTTATTCGAAACTCCTGGAATTTTCAGTTTCCATATCCACTCTTACCAATGTTGATT; TTGTTGGNAGACTCCACTGCAACCTGNCAAACCCTGCCTAAGAAA;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001074 unedited; TTTCTCGCTGGCATAAACTGAAGTATCGACCTAAAGGTTTTCCAGCTTCAAATATCAGGT; ATAACTAATCATTTTTATCCTTCTTTGCTTTTGTAGCAAACTTCCAGAAACAAAACAGAC; AACATTTTGTGACGATAAATATCACAGTTGCCACACAGACCAGCAGGAACCCAATCACAT; CCAAAGAGTGGTACTGGAACCAGGTGAGGTCGTGGGCTGCAACCCGAAGGTGTTTAGCTC; CTTTGTGGCGCATGACAAATTCAATCCAGAAGACTGCTCGATCCAGGGGCTTCACTGGTT; GATATATGTTGAATTCTTGATAATTTCATAACATTCTCTTTATATGAAGGATCATTAATT; ACTCTCTTCAATGCATTCAGCAAGTCTGTACTCGACATTGCGTTGAAGTCCACTCTAACA; GCTGCTCCCCTGGCCTTCATGTGAGCAAATGTTATCAGGTTGATCGGCAAACAATGGAAT; CCCCACCCATAGGGATCCCATGGTAGATTGCCTCGTAGATGCCATGGGCTCCACCATGAA; GTATAAAGCTCTGGGCTTTGGATGACCCTAGAAGGACATTCTGGGGTATCCACTTTGTAA; AGCCAAGTTTGAGACCTAAGGTATTTGGTTTATTCCCCATCAAAACTTCCCGGAACTCTT; TGTGGGAACTGGGCCAGGGCTTGATGCAATTACCTAGGGCCTTTTATTCTGGCCAGTTAC; TGAACACTCCCCCCCAGAGAAAAACCCCCACCACCCTCTTTACGAGAGAGTTGGGGCAAA; GGGTTTCTCATTCCTTAAGGAACGGTGTTTGCAAGGTTTGAATGGTAGACCCCCCACGGA; ATTAATTTTGGCAAAGGGGTATTGCGAAACTGAAAATCGAGAGTTCGAAATACCCATAGT; CGGGTTTGCCCGTTGGTACAAAAAGTGGGGGGG;
• Restriction Sites: NotI-NotI
• ACCN: NM_001074
• Insert Size: 1750 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.; ; The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001074.1, NP_001065.1
• RefSeq Size: 1855 bp
• RefSeq ORF: 1590 bp
• Locus ID: 7364
• UniProt ID: P16662
• Cytogenetics: 4q13.2
• Domains: UDPGT
• Protein Families: Transmembrane
• Protein Pathways: Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism
• Summary: The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]; Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).