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UGT1A6 (NM_001072) Human Untagged Clone

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SKU
SC119463
UGT1A6 (untagged)-Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1
  $744.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol UGT1A6
Synonyms GNT1; HLUGP; HLUGP1; hUG-BR1; UDPGT; UDPGT 1-6; UGT-1A; UGT-1C; UGT-1E; UGT-1F; UGT1; UGT1-01; UGT1-03; UGT1-05; UGT1-06; UGT1.1; UGT1.3; UGT1.5; UGT1.6; UGT1A; UGT1A1; UGT1A3; UGT1A5; UGT1A6S; UGT1C; UGT1E; UGT1F
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC119463 sequence for NM_001072 edited (data generated by NextGen Sequencing)
ATGGCCTGCCTCCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTT
TGGGGCATGGTTGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTT
AGTATGAAGGATATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTG
CCTGAAGTTAATTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTG
CCGTATGACCAAGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCT
GAGCGATCATTCCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGC
CTGTACTTCATCAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAG
GAGAGCAAGTTTGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCT
GAGTATTTGGGCCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCAT
ACATTCAGCAGAAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCA
GACCACATGACTTTTTCCCAACGAGTGGCCAACTTCCTTGTTAATTTGTTGGAGCCCTAT
CTATTTTATTGTCTGTTTTCAAAGTATGAAGAACTCGCATCAGCTGTCCTCAAGAGAGAT
GTGGATATAATCACCTTATATCAGAAGGTCTCTGTTTGGCTGTTAAGATATGACTTTGTG
CTTGAATATCCTAGGCCGGTCATGCCCAACATGGTCTTCATTGGAGGTATCAACTGTAAG
AAGAGGAAAGACTTGTCTCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGA
ATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCA
ATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGA
CCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTT
GGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGC
ATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCA
AAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAA
GATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATG
CGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGG
GTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTC
ACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACA
GTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAA
GGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA

Clone variation with respect to NM_001072.3
5' Read Nucleotide Sequence
>OriGene 5' read for NM_001072 unedited
GGCCCCCGGGCCCNNNNNNNCCNCCTCCCCCCCCTGTTCAAATTTGTNATACGACTCATA
TAGGCGGCCGCGNAATTCGCACGAGGTTAGTTTAGGGAAAATACCTAGAGCCCTGTGATT
TGGAGAGTGAAAACTCTTTATTACCGTTGTTACTTTAACTCTTTCCAGGATGGCCTGCCT
CCTTCGCTCATTTCAGAGAATTTCTGCAGGGGTTTTCTTCTTAGCACTTTGGGGCATGGT
TGTAGGTGACAAGCTGCTGGTGGTCCCTCAGGACGGAAGCCACTGGCTTAGTATGAAGGA
TATAGTTGAGGTTCTCAGTGACCGGGGTCATGAGATTGTAGTGGTGGTGCCTGAAGTTAA
TTTGCTTTTGAAAGAATCCAAATACTACACAAGAAAAATCTATCCAGTGCCGTATGACCA
AGAAGAGCTGAAGAACCGTTACCAATCATTTGGAAACAATCACTTTGCTGAGCGATCATT
CCTAACTGCTCCTCAGACAGAGTACAGGAATAACATGATTGTTATTGGCCTGTACTTCAT
CAACTGCCAGAGCCTCCTGCAGGACAGGGACACCCTGAACTTCTTTAAGGAGAGCAAGTT
TGATGCTCTTTTCACAGACCCAGCCTTACCCTGTGGGGTGATCCTGGCTGAGTATTTGGG
CCTACCATCTGTGTACCTCTTCAGGGGTTTTCCGTGTTCCCTGGAGCATACATTCAGCAG
AAGCCCAGACCCTGTGTCCTACATTCCCAGGTGCTACACAAAGTTTTCAGACCACATGAC
TTTNTCCCAACGAGTGGCCAACTTCCTTGNTAATTTGTTGGAGCCCTATCTATTNTATTG
NCTGTTTTCAAATATGAAAAACTCGCATCAGCTGTCCTCAGAAGAGATGTGGATATAATC
ACCTATATCAGAA
3' Read Nucleotide Sequence
>OriGene 3' read for NM_001072 unedited
TCACTCTGGACCCGCGGCCGCAANCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTATAAAAATTAATTAATTTATTTTTAGTGGGAGGAAACATCAAAAAAA
AATAAACTTGCCCAGCACTTCATAGCTGTATTTGGGGTTTTTATCAAATTCAGCTCCATT
TGACATAAGCAATGATTATTTTCTCAAATACCCCACCCACCAATTTCATAGCATCATTTT
TTTTCCCCAAAGCAAAAAATCATATGCTGTTCTCAGGGCACTCCAAGCCATTCATTCATT
TCACCTACACTTTAAAGGGACAAAGCTTCCCTTTTTTAAACACACAAGGGGGCCCCTATG
AAGCCCGACAGAGATGAGGACTGACCATTATTGGTTAAGGATCAATTGCAACCATCTGCA
GAAGCCAAAAGATAAAATTAAAACTGCCATTTGCAGTAGGGGCAGCCGGGGGACCACCTT
TGAATCCCGCACTCCCAAACAGGCCATGTTTCAAAGTAAAAAAAGTAATCTAAAATGCCA
GCCTGTCTGCACGTCCTTTGAAAAATGGCACATGTCATCCTGATCAAAGACACCAGAGGG
GGCACGATACATATTCAAATATCTTTACTGACTAGCGAGTCTATTATTTTTATTTAAAAG
AATTTTTTAAAGCACTCTGGGGGCTGATATAATTATGCAAAGTATTTCCTTAATAAGATA
AAATGAATTTACACTGATTCTGTTTTTCAGTTTGGAAAGACTAGGGAATGGTTCAAATTT
TACCTTATTTCCACCCACTCTCATGGGTCTGGNATTTGGGGGCTTTCTTACTCGCCCTTT
TTCCCAGCATTTTCGGTAGCTAGCACACATTTAAGTGATGAAGGCCCTGTANCACGACGC
CAGAGAACCAATACGTCAGGATGTACTGTACAATGAGGTCCTGGCTGCGGCCCAAGGTGC
GCCCCT
Restriction Sites NotI-NotI |
ACCN NM_001072
Insert Size 2560 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001072.2, NP_001063.2
RefSeq Size 2435 bp
RefSeq ORF 1599 bp
Locus ID 54578
UniProt ID P19224, Q5DSZ8
Cytogenetics 2q37.1
Domains UDPGT
Protein Families Transmembrane
Protein Pathways Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism
Summary This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. provided by RefSeq, Jul 2008
Transcript Variant: This variant (1) represents the longer transcript. Its first exon contains both the 5' UTR and the 5' coding sequence, as is typical of the UGT1A genes.
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Documents
Resources
"NM_001072" in other vectors (6)
SKU Description Size Price
RC215957 UGT1A6 (Myc-DDK-tagged)-Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1 10 ug
$743.00
RC215957L1 Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1, Myc-DDK-tagged 10 ug
$1,043.00
RC215957L2 Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1, mGFP tagged 10 ug
$1,043.00
RC215957L3 Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1, Myc-DDK-tagged 10 ug
$1,043.00
RC215957L4 Lenti ORF clone of Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1, mGFP tagged 10 ug
$1,043.00
RG215957 UGT1A6 (tGFP-tagged) - Human UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1 10 ug
$943.00

file-alt Citations

Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines
Dates, Fahmi, Pyrek et al
Cancer Biol. Ther. (2015) 16 (5), 714-23 DOI: 10.1080/15384047.2015.1026480
Cited by 24
AI Summary: OriGene’s human cDNA clone SC119463 was used as the template to amplify the UGT1A6 coding sequence for expression studies in this paper.
Snippet: The DsRed-Express sequence from the bicistronic expression vector pIRES2-DsRed-Express (Clontech) was then removed by BstXI and NotI digestion and replaced with the mCherry sequence to yield the plasmid pIRES2-mCherry. The UGT1A6 coding sequence was amplified from the human cDNA clone SC119463 (Origene) with primers that added an XhoI and BamHI site to the 5’ and 3’ ends, respectively. …
Showing 1-1 of 1 papers.
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