ADAR1 (ADAR) (NM_001111) Human Untagged Clone
$1,602.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | ADAR1 |
| Synonyms | ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; P136 |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_001111 |
| Insert Size | 7000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_001111.3, NP_001102.2 |
| RefSeq Size | 6640 bp |
| RefSeq ORF | 3681 bp |
| Locus ID | 103 |
| UniProt ID | P55265 |
| Cytogenetics | 1q21.3 |
| Domains | A_deamin, DSRM, z-alpha |
| Protein Families | Druggable Genome |
| Protein Pathways | Cytosolic DNA-sensing pathway |
| Summary | This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2010 Transcript Variant: This variant (1) encodes isoform (a, also referred to as ADAR-a). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_001111" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC207522 | ADAR (Myc-DDK-tagged)-Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1 | 10 ug |
$589.00
$1,600.00
|
|
| RC207522L1 | Lenti ORF clone of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,900.00
|
|
| RC207522L2 | Lenti ORF clone of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1, mGFP tagged | 10 ug |
$1,900.00
|
|
| RC207522L3 | Lenti ORF clone of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,900.00
|
|
| RC207522L4 | Lenti ORF clone of Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1, mGFP tagged | 10 ug |
$1,900.00
|
|
| RG207522 | ADAR (tGFP-tagged) - Human adenosine deaminase, RNA-specific (ADAR), transcript variant 1 | 10 ug |
$789.00
$1,800.00
|
|
Citations
PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas
Yang, Hu, Lin et al
Cell. Mol. Life Sci. (2015)
Yang, Hu, Lin et al
Cell. Mol. Life Sci. (2015)
Cited by 46
New non-coding lytic transcripts derived from the Epstein Barr virus latency origin of replication oriP are hyper-edited, bind the paraspeckle protein, NONO/p54nrb, and support lytic viral transcription
Cao, Moss, O'Grady et al
J. Virol. (2015)
Cao, Moss, O'Grady et al
J. Virol. (2015)
AI Summary: OriGene products contributed to this study by providing the ADAR1 (Cat. #SC119438) and HDLBP (Cat. #SC116829) cDNA clones, which were used for in-frame cloning into expression vectors to investigate the roles of these proteins in Epstein-Barr virus lytic transcript processing and function.
Five novel mutations in the ADAR1 gene associated with dyschromatosis symmetrica hereditaria
Liu, Wang, Wu et al
BMC Med. Genet. (2014) 15 (1), 69 DOI: 10.1186/1471-2350-15-69
Liu, Wang, Wu et al
BMC Med. Genet. (2014) 15 (1), 69 DOI: 10.1186/1471-2350-15-69
Cited by 23
F11R Expression upon Hypoxia Is Regulated by RNA Editing
Ben-Zvi, Amariglio, Paret et al
PLoS ONE (2013) 8 (10), e77702 DOI: 10.1371/journal.pone.0077702
Ben-Zvi, Amariglio, Paret et al
PLoS ONE (2013) 8 (10), e77702 DOI: 10.1371/journal.pone.0077702
Cited by 25
AI Summary: OriGene’s ADAR1 expression vector (variant 1, pCMV6 backbone) was used in this study to investigate the role of ADAR1 in F11R RNA editing under hypoxic conditions.
Snippet: The optimal concentration of siRNA was 20μM for ADAR1 and 40μM for ADAR2. Plasmids. An ADAR1 expression vector (variant 1, pCMV6 backbone) was obtained from Origene. An empty pRc/CMV plasmid was used as control.
Showing 1-4 of 4 papers.
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