Integrin beta 5 (ITGB5) (NM_002213) Human Untagged Clone
$1,098.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | Integrin beta 5 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_002213 |
| Insert Size | 3410 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002213.3, NP_002204.2 |
| RefSeq Size | 3392 bp |
| RefSeq ORF | 2400 bp |
| Locus ID | 3693 |
| UniProt ID | P18084 |
| Cytogenetics | 3q21.2 |
| Domains | EGF, INB, PSI, VWA |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton |
| Summary | This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. provided by RefSeq, Aug 2017 Transcript Variant: This variant (1) encodes the longest isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002213" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC200731 | ITGB5 (Myc-DDK-tagged)-Human integrin, beta 5 (ITGB5) | 10 ug |
$1,097.00
|
|
| RC200731L1 | Lenti ORF clone of Human integrin, beta 5 (ITGB5), Myc-DDK-tagged | 10 ug |
$1,397.00
|
|
| RC200731L2 | Lenti ORF clone of Human integrin, beta 5 (ITGB5), mGFP tagged | 10 ug |
$1,397.00
|
|
| RC200731L3 | Lenti ORF clone of Human integrin, beta 5 (ITGB5), Myc-DDK-tagged | 10 ug |
$1,397.00
|
|
| RC200731L4 | Lenti ORF clone of Human integrin, beta 5 (ITGB5), mGFP tagged | 10 ug |
$1,397.00
|
|
| RG200731 | ITGB5 (tGFP-tagged) - Human integrin, beta 5 (ITGB5) | 10 ug |
$1,297.00
|
|
Citations
Vitronectin is Involved in the Morphological Transition of Neurites in Retinoic Acid-Induced Neurogenesis of Neuroblastoma Cell Line Neuro2a
Sugahara, Nakaoki, Yamaguchi et al
Neurochem. Res. (2019)
Sugahara, Nakaoki, Yamaguchi et al
Neurochem. Res. (2019)
AI Summary: OriGene products contributed to this study by providing the integrin expression plasmid vectors (pCMV6-XL-β3 integrin, pCMV6-XL-β5 integrin, and pCMV6-XL plasmid vector), which were used to investigate the role of integrins in vitronectin-mediated neurite morphological transitions in Neuro2a cells.
Snippet: incubated for 5 h. Transfection of Vectors Integrin expression plasmid vectors (pCMV6-XL-β3 inte- grin, pCMV6-XL-β5 integrin, or pCMV6-XL plasmid vector) were obtained from OriGene (Rockville, MD). A dominant negative Par6
Showing 1-1 of 1 papers.
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