RASA1 (NM_002890) Human Untagged Clone
SKU
SC118332
RASA1 (untagged)-Human RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1
$912.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | RASA1 |
| Synonyms | CM-AVM; CMAVM; CMAVM1; GAP; p120; p120GAP; p120RASGAP; PKWS; RASA; RASGAP |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_002890 |
| Insert Size | 4230 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002890.1, NP_002881.1 |
| RefSeq Size | 4307 bp |
| RefSeq ORF | 3144 bp |
| Locus ID | 5921 |
| UniProt ID | P20936 |
| Cytogenetics | 5q14.3 |
| Domains | C2, PH, RasGAP, SH2, SH3 |
| Protein Families | Druggable Genome |
| Protein Pathways | Axon guidance, MAPK signaling pathway |
| Summary | The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. provided by RefSeq, May 2012 Transcript Variant: This variant (1) lacks the alternatively spliced insert found in variant 2, resulting in translation of the longer isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002890" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC205473 | RASA1 (Myc-DDK-tagged)-Human RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1 | 10 ug |
$911.00
|
|
| RC205473L1 | Lenti ORF clone of Human RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,211.00
|
|
| RC205473L2 | Lenti ORF clone of Human RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1, mGFP tagged | 10 ug |
$1,211.00
|
|
| RC205473L3 | Lenti ORF clone of Human RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,211.00
|
|
| RC205473L4 | Lenti ORF clone of Human RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1, mGFP tagged | 10 ug |
$1,211.00
|
|
| RG205473 | RASA1 (tGFP-tagged) - Human RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1 | 10 ug |
$789.00
$1,111.00
|
|
Citations
Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation
Sung, Kanchi, Wang et al
Oncotarget (2016) 7 (17), 23885-96 DOI: 10.18632/oncotarget.8127
Sung, Kanchi, Wang et al
Oncotarget (2016) 7 (17), 23885-96 DOI: 10.18632/oncotarget.8127
Snippet: instructions. Coding regions of each wild type and mutants were clonedinto the pQCXP-puro- (a gift of Dr. Scott and Dr. Chin) via Gateway cloning system(Invitrogen). pCMV6-XL4-RASA1 was purchased from OriGene. The ... Cite SaveSaving
Showing 1-1 of 1 papers.
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