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YY1 (NM_003403) Human Untagged Clone

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SKU
SC118004
YY1 (untagged)-Human YY1 transcription factor (YY1)
  $457.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol YY1
Synonyms DELTA; GADEVS; INO80S; NF-E1; UCRBP; YIN-YANG-1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_003403 edited
GCCTCTGCCTTCCTTCCCCACGGCCGGCCGCCTCCTCGCCCGCCCGCCCGCAGCCGAGGA
GCCGAGGCCGCCGCGGCCGTGGCGGCGGAGCCCTCAGCCATGGCCTCGGGCGACACCCTC
TACATCGCCACGGACGGCTCGGAGATGCCGGCCGAGATCGTGGAGCTGCACGAGATCGAG
GTGGAGACCATCCCGGTGGAGACCATCGAGACCACAGTGGTGGGCGAGGAGGAGGAGGAG
GACGACGACGACGAGGACGGCGGCGGTGGCGACCACGGCGGCGGGGGCGGCCACGGGCAC
GCCGGCCACCACCACCACCACCATCACCACCACCACCACCCGCCCATGATCGCTCTGCAG
CCGCTGGTCACCGACGACCCGACCCAGGTGCACCACCACCAGGAGGTGATCCTGGTGCAG
ACGCGCGAGGAGGTGGTGGGCGGCGACGACTCGGACGGGCTGCGCGCCGAGGACGGCTTC
GAGGATCAGATTCTCATCCCGGTGCCCGCGCCGGCCGGCGGCGACGACGACTACATTGAA
CAAACGCTGGTCACCGTGGCGGCGGCCGGCAAGAGCGGCGGCGGCGGCTCGTCGTCGTCG
GGAGGCGGCCGCGTCAAGAAGGGCGGCGGCAAGAAGAGCGGCAAGAAGAGTTACCTCAGC
GGCGGGGCCGGCGCGGCGGGCGGCGGCGGCGCCGACCCGGGCAACAAGAAGTGGGAGCAG
AAGCAGGTGCAGATCAAGACCCTGGAGGGCGAGTTCTCGGTCACCATGTGGTCCTCAGAT
GAAAAAAAAGATATTGACCATGAGACAGTGGTTGAAGAACAGATCATTGGAGAGAACTCA
CCTCCTGATTATTCAGAATATATGACAGGAAAGAAACTTCCTCCTGGAGGAATACCTGGC
ATTGACCTCTCAGATCCCAAACAACTGGCAGAATTTGCTAGAATGAAGCCAAGAAAAATT
AAAGAAGATGATGCTCCAAGAACAATAGCTTGCCCTCATAAAGGCTGCACAAAGATGTTC
AGGGATAACTCGGCCATGAGAAAACATCTGCACACCCACGGTCCCAGAGTCCACGTCTGT
GCAGAATGTGGCAAAGCTTTTGTTGAGAGTTCAAAACTAAAACGACACCAACTGGTTCAT
ACTGGAGAGAAGCCCTTTCAGTGCACGTTCGAAGGCTGTGGGAAACGCTTTTCACTGGAC
TTCAATTTGCGCACACATGTGCGAATCCATACCGGAGACAGGCCCTATGTGTGCCCCTTC
GATGGTTGTAATAAGAAGTTTGCTCAGTCAACTAACCTGAAATCTCACATCTTAACACAT
GCTAAGGCCAAAAACAACCAGTGAAAAGAAGAGAGAAGACCCTTCTCGACCACGGGAAGC
ATCTTCCAGAAGTGTGATTGGGAATAAATATGCCTCTCCTTTGTATATTATTTCTAGGAA
GAAT
5' Read Nucleotide Sequence
>OriGene 5' read for NM_003403 unedited
TCTATCCCCCGCCCGTTGCCGCAAATGGGCGTAGGCGTGTACGGTGGGAGGTCTATATAA
GCAGAGCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGC
GAATTCGGCACGAGGCCTCTGCCTTCCTTCCCCACGGCCGGCCGCCTCCTCGCCCGCCCG
CCCGCAGCCGAGGAGCCGAGGCCGCCGCGGCCGTGGCGGCGGAGCCCTCAGCCATGGCCT
CGGGCGACACCCTCTACATCGCCACGGACGGCTCGGAGATGCCGGCCGAGATCGTGGAGC
TGCACGAGATCGAGGTGGAGACCATCCCGGTGGAGACCATCGAGACCACAGTGGTGGGCG
AGGAGGAGGAGGAGGACGACGACGACGAGGACGGCGGCGGTGGCGACCACGGCGGCGGGG
GCGGCCACGGGCACGCCGGCCACCACCACCACCACCATCACCACCACCACCACCCGCCCA
TGATCGCTCTGCAGCCGCTGGTCACCGACGACCCGACCCAGGTGCACCACCACCAGGAGG
TGATCCTGGTGCAGACGCGCGAGGAGGTGGTGGGCGGCGACGACTCGGACGGGCTGCGCG
CCGAGGACGGCTTCGAGGATCAGATTCTCATCCCGGTGCCCGCGCCGGCCGGCGGCGACG
ACGACTACATTGAACAAACGCTGGTCACCGTGGCGGCGGCCGGCAAGAGCGGCGGCGGCG
GCTCGTCGTCGTCGGGAGGCGGCCGCGTCAAGAAAGGCGGCNGCAAGAAGAGCGGCAAGA
AGAGTTACCTNCAGCGCGGGGCCCGCGCGGCGGGNCGGCGCNGCCCCCACCCGGGCACAA
GAAGTGGGAGCAGAAGCAGGTGCAGATCAAGACCCTGGAGGGGCGAGTCTCGGTCACCAT
GTGGTCCTCAGATGAAAAAAAGAATT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_003403 unedited
NTTACTTGNACCGCGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTACTACTTTA
TCAAAACATGTCCCTTAGGTGTGTAGGATTCATTTTTAAAATTCTTCCTAGAAATAATAT
ACAAAGGAGAGGCATATTTATTCCCAATCACACTTCTGGAAGATGCTTCCCGTGGTCGAG
AAGGGTCTTCTCTCTTCTTTTCACTGGTTGTTTTTGGCCTTAGCATGTGTTAAGATGTGA
GATTTCAGGTTAGTTGACTGAGCAAACTTCTTATTACAACCATCGAAGGGGCACACATAG
GGCCTGTCTCCGGTATGGATTCGCACATGTGTGCGCAAATTGAAGTCCAGTGAAAAGCGT
TTCCCACAGCCTTCGAACGTGCACTGAAAGGGCTTCTCTCCAGTATGAACCAGTTGGTGT
CGTTTTAGTTTTGAACTCTCAACAAAAGCTTTGCCACATTCTGCACAGACGTGGACTCTG
GGACCGTGGGTGTGCAGATGTTTTCTCATGGCCGAGTTATCCCTGAACATCTTTGTGCAG
CCTTTATGAGGGCAAGCTATTGTTCTTGGAGCATCATCTTCTTTAATTTTTCTTGGCTTC
ATTCTAGCAAATTCTGCCAGTTGTTTGGGATCTGAGAGGTCAATGCCAGGTATTCCTCCA
GGAGGAAGTTTCTTTCCTGTCATATATTCTGAATAATCAGGAGGTGAGTTCTCTCCAATG
ATCTGGTCTTCAACCACTGTCTCATGGGCAATATCTTTTTTTTCATCTGAAGACCACATG
GTGACCGAGAACTCGCCCTCCGGGGCTTGATCTGCACCTGTTTCTGCTTCCACTCCTGTT
GCCCCGGTCGGGGCCCCCCCCCGCCGCCGGGCCGGTCCCCGCCGTGAATAACCTTTTTTG
CCCGTTTTTTGGCCCCCCCCTTTTGCCCGGGCGCCTCCCAAGACGAA
Restriction Sites NotI-NotI |
ACCN NM_003403
Insert Size 1640 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_003403.3, NP_003394.1
RefSeq Size 2592 bp
RefSeq ORF 1245 bp
Locus ID 7528
UniProt ID P25490
Cytogenetics 14q32.2
Domains zf-C2H2
Protein Families Druggable Genome, Transcription Factors
Summary YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. provided by RefSeq, Jul 2008
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Documents
Resources
"NM_003403" in other vectors (6)
SKU Description Size Price
RC207198 YY1 (Myc-DDK-tagged)-Human YY1 transcription factor (YY1) 10 ug
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RC207198L1 Lenti ORF clone of Human YY1 transcription factor (YY1), Myc-DDK-tagged 10 ug
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RC207198L2 Lenti ORF clone of Human YY1 transcription factor (YY1), mGFP tagged 10 ug
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RC207198L3 Lenti ORF clone of Human YY1 transcription factor (YY1), Myc-DDK-tagged 10 ug
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RC207198L4 Lenti ORF clone of Human YY1 transcription factor (YY1), mGFP tagged 10 ug
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RG207198 YY1 (tGFP-tagged) - Human YY1 transcription factor (YY1) 10 ug
$489.00 $657.00

file-alt Citations

Suitability of Yin Yang 1 transcript and protein levels for biomarker studies in B cell non-Hodgkin lymphoma
Arribas Arranz, Winter, Drexler et al
Biomark Res (2018) 6, 11 DOI: 10.1186/s40364-018-0126-y
AI Summary: OriGene’s YY1 expression vector (SC118004) and the corresponding empty vector pCMV6 were used in this study to manipulate YY1 levels in B-NHL cell lines, enabling the authors to assess the relationship between YY1 transcript and protein expression.
Snippet: YY1 expression vector (YY1.V) encoding the full-length cDNA of human YY1 (SC118004;Origene) or its corresponding empty vector pCMV6 (EV) were transfected into U2932-R1 cells using Lonza Nucleofection Kit (SF Cell Line 4D-Nucleofector X Kit L;Lonza) Cached
FigureFigureFigure
Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding
Sun, Wu, Chen
World J. Gastroenterol. (2017) 23 (48), 8500-8511 DOI: 10.3748/wjg.v23.i48.8500
AI Summary: OriGene products contributed to this study by providing the pCMV-YY1 vector (expressing full-size YY1) and the control pCMV6-XL5 vector, which were used in cell transfection and reporter assays to investigate the functional role of YY1 binding to the TBX21 promoter.
Snippet: The pCMV-YY1 vector expressing full-size YY1 and its control pCMV6-XL5 were obtained from OriGene. Cell transfection and luciferase assay. Harvested cells were suspended in each culture medium supplemented with additional 10% fetal calf serum (FCS)
FigureFigureFigure
The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia
Fernando, Contreras, Zampini et al
Mol. Cancer (2017) 16 (1), 126 DOI: 10.1186/s12943-017-0692-x
AI Summary: OriGene’s pCMV-YY1 expression plasmid (OriGene-SC118004) was used to overexpress the YY1 transcription factor in HEK 293T cells, enabling the authors to investigate how CASC15 and YY1 together regulate SOX4 promoter activity in acute leukemia.
Snippet: HEK 293 T cells were transfected with the pGL4.75 and pGL4.11 containing reporter vectors at a 1:10 ratio (10 ng:100 ng), along with a combination of pCMV (empty or YY1: Origene-SC118004) and MSCV (empty or CASC15) vectors at a 1:5 ratio (10 ng:50 ng), or a ... … HEK 293 T cells were transfected with the pGL4.75 and pGL4.11 containing reporter vectors at a 1:10 ratio (10 ng:100 ng), along with a combination of pCMV (empty or YY1: Origene-SC118004) and MSCV (empty or CASC15) vec- tors at a 1:5 ratio (10 ng:50 ng), or ... … HEK 293 T cells were transfected with the pGL4.75 and pGL4.11 containing reporter vectors at a 1:10 ratio (10 ng:100 ng), along with a combination of pCMV (empty or YY1: Origene-SC118004) and MSCV (empty or CASC15) vectors at a 1:5 ratio (10 ng:50 ng), or a ... …
FigureFigureFigure
Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome
Friese, Ye, Nievergelt et al
Circ Cardiovasc Genet (2012) 5 (4), 430-40 DOI: 10.1161/CIRCGENETICS.111.962415
AI Summary: In this study, the OriGene product "YY1 (Homo sapiens; SC118004)" was used to investigate the transcriptional activity of the YY1 transcription factor, helping to identify its role as a potential genetic control point in essential hypertension and the cardiometabolic syndrome.
Snippet: 9,10 In short, adrenal gene expression of BPH and BPL mice (n=3, juvenile BPH;n=3, adult BPH;n=3 ... Sox17 (Danio rerio;MDR1734–97029554, Open Biosystems), Sry (Rattus norvegicus;Sry1/pcDNA3.1), 19 or YY1 (Homo sapiens;SC118004, OriGene, Rockville, MD).
CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose
Chaudhry, Urban, Lamba et al
J Pharmacol Exp Ther (2010) 332 (2), 599-611 DOI: 10.1124/jpet.109.161026
Cited by 55
AI Summary: OriGene products contributed to this study by providing the CYP2C9 promoter reporter constructs (Cat# HPRM13241 and Cat# SC118041), which were used in transfection assays to assess the functional impact of CYP2C9 promoter polymorphisms on gene induction by phenytoin.
The role of activating protein 1 in the transcriptional regulation of the human FCGR2B promoter mediated by the -343 G -> C polymorphism associated with systemic lupus erythematosus
Olferiev, Masuda, Tanaka et al
J Biol Chem (2007) 282 (3), 1738-46 DOI: 10.1074/jbc.M605808200
AI Summary: In this study, OriGene products—specifically the c-Jun (SC1183) and Yin-Yang 1 (SC-7341) antibodies—were used in promoter pulldown and chromatin immunoprecipitation assays to investigate the binding of these transcription factors to the FCGR2B promoter and elucidate the molecular mechanisms underlying the regulation of its activity in the context of systemic lupus erythematosus-associated polymorp...
Showing 1-6 of 6 papers.
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