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CXCR4 (NM_003467) Human Untagged Clone

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SKU
SC117951
CXCR4 (untagged)-Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2
  $686.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol CXCR4
Synonyms CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_003467 edited
GAATTCGGCACGAGGGCCGAGGGCCTGAGTGCTCCAGTAGCCACCGCATCTGGAGAACCA
GCGGTTACCATGGAGGGGATCAGTATATACACTTCAGATAACTACACCGAGGAAATGGGC
TCAGGGGACTATGACTCCATGAAGGAACCCTGTTTCCGTGAAGAAAATGCTAATTTCAAT
AAAATCTTCCTGCCCACCATCTACTCCATCATCTTCTTAACTGGCATTGTGGGCAATGGA
TTGGTCATCCTGGTCATGGGTTACCAGAAGAAACTGAGAAGCATGACGGACAAGTACAGG
CTGCACCTGTCAGTGGCCGACCTCCTCTTTGTCATCACGCTTCCCTTCTGGGCAGTTGAT
GCCGTGGCAAACTGGTACTTTGGGAACTTCCTATGCAAGGCAGTCCATGTCATCTACACA
GTCAACCTCTACAGCAGTGTCCTCATCCTGGCCTTCATCAGTCTGGACCGCTACCTGGCC
ATCGTCCACGCCACCAACAGTCAGAGGCCAAGGAAGCTGTTGGCTGAAAAGGTGGTCTAT
GTTGGCGTCTGGATCCCTGCCCTCCTGCTGACTATTCCCGACTTCATCTTTGCCAACGTC
AGTGAGGCAGATGACAGATATATCTGTGACCGCTTCTACCCCAATGACTTGTGGGTGGTT
GTGTTCCAGTTTCAGCACATCATGGTTGGCCTTATCCTGCCTGGTATTGTCATCCTGTCC
TGCTATTGCATTATCATCTCCAAGCTGTCACACTCCAAGGGCCACCAGAAGCGCAAGGCC
CTCAAGACCACAGTCATCCTCATCCTGGCTTTCTTCGCCTGTTGGCTGCCTTACTACATT
GGGATCAGCATCGACTCCTTCATCCTCCTGGAAATCATCAAGCAAGGGTGTGAGTTTGAG
AACACTGTGCACAAGTGGATTTCCATCACCGAGGCCCTAGCTTTCTTCCACTGTTGTCTG
AACCCCATCCTCTATGCTTTCCTTGGAGCCAAATTTAAAACCTCTGCCCAGCACGCACTC
ACCTCTGTGAGCAGAGGGTCCAGCCTCAAGATCCTCTCCAAAGGAAAGCGAGGTGGACAT
TCATCTGTTTCCACTGAGTCTGAGTCTTCAAGTTTTCACTCCAGCTAACACAGATGTAAA
AGACTTTTTTTTATACGATAAATAACTTTTTTTTAAGTTACACATTTTTCAGATATAAAA
GACTGACCAATATTGTACAGTTTTTATTGCTTGTTGGATTTTTGTCTTGTGTTTCTTTAG
TTTTTGTGAAGTTTAATTGACTTATTTATATAAATTTTTTTTTGTTTCATATTGATGTGT
GTCTAGGCAGGACCTGTGGCCAAGTTCTTAGTTGCTGTATGTCTCGTGGTAGGACTGTAG
AAAAGGGAACTGAACATTCCAGAGCGTGTAGTGAATCACGTAAAGCTAGAAATGATCCCC
AGCTGTTTATGCATAGATAATCTCTCCATTCCCGTGGAACGTTTTTCCTGTTCTTAAGAC
GTGATTTTGCTGTAGAAGATGGCACTTATAACCAAAGCCCAAAGTGGTATAGAAATGCTG
GTTTTTCAGTTTTCAGGAGTGGGTTGATTTCAGCACCTACAGTGTACAGTCTTGTATTAA
GTTGTTAATAAAAGTACATGTTAAACTTAAAAAAAAAAAAAAAAAACTCGAC
5' Read Nucleotide Sequence
>OriGene 5' read for NM_003467 unedited
TTACTATTTGTATACGACTCACTATAGGGNNCGGCCGCGCAATTCGGCACGAGGGCCGAG
GGCCTGAGTGCTCCAGTAGCCACCGCATCTGGAGAACCAGCGGTTACCATGGAGGGGATC
AGTATATACACTTCAGATAACTACACCGAGGAAATGGGCTCAGGGGACTATGACTCCATG
AAGGAACCCTGTTTCCGTGAAGAAAATGCTAATTTCAATAAAATCTTCCTGCCCACCATC
TACTCCATCATCTTCTTAACTGGCATTGTGGGCAATGGATTGGTCATCCTGGTCATGGGT
TACCAGAAGAAACTGAGAAGCATGACGGACAAGTACAGGCTGCACCTGTCAGTGGCCGAC
CTCCTCTTTGTCATCACGCTTCCCTTCTGGGCAGTTGATGCCGTGGCAAACTGGTACTTT
GGGAACTTCCTATGCAAGGCAGTCCATGTCATCTACACAGTCAACCTCTACAGCAGTGTC
CTCATCCTGGCCTTCATCAGTCTGGACCGCTACCTGGCCATCGTCCACGCCACCAACAGT
CAGAGGCCAAGGAAGCTGTTGGCTGAAAAGGTGGTCTATGTTGGCATCTGGATCCCTGCC
CTCCTGCTGACTATTCCCGACTTCATCTTTGCCAACGTCAGTGAGGCAGATGACAGATAT
ATCTGTGACCGCTCCTACCCCATGACTTGTGGGTGTTTGTGTTCCAGTTTCAGCACATAA
TGGTTTGGCCTTATCCTGCCTTGTTATGGCCATCCTGTCCTGCTATTGCATTATCATCTC
CAAGCTGTTACATTCCAGGGGCCACAGAAAGCGCAAGCCCCTCAAGACCACAGGCATCCT
CATCCTTGCTTTTTTCGCCTGTGGCTGGCTTACTACATTGGGTACAGGATTGACTCCTTA
ATCCTCTGGAAAAATCAACCAAGGGGTGAG
3' Read Nucleotide Sequence
>OriGene 3' read for NM_003467 unedited
TGGACCGCGGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTAAGTTTAACATGT
ACTTTTATTAACAACTTAATACAAGACTGTACACTGTAGGTGCTGAAATCAACCCACTCC
TGAAAACTGAAAAACCAGCATTTCTATACCACTTTGGGCTTTGGTTATAAGTGCCATCTT
CTACAGCAAAATCACGTCTTAAGAACAGGAAAAACGTTCCACGGGAATGGAGAGATTATC
TATGCATAAACAGCTGGGGATCATTTCTAGCTTTACGTGATTCACTACACGCTCTGGAAT
GTTCAGTTCCCTTTTCTACAGTCCTACCACGAGACATACAGCAACTAAGAACTTGGCCAC
AGGTCCTGCCTAGACACACATCAATATGAAACAAAAAAAAATTTATATAAATAAGTCAAT
TAAACTTCACAAAAACTAAAGAAACACAAGACAAAAATCCAACAAGCAATAAAAACTGTA
CAATATTGGTCAGTCTTTTATATCTGAAAAATGTGTAACTTAAAAAAAAGTTATTTATCG
TATAAAAAAAAGTCTTTTACATCTGTGTTAGCTGGAGTGAAAACTTGAAGACTCAGACTC
AGTGGAAACAGATGAATGTCCACCTCGCTTTCCTTTGGAGAGGATCTTGAGGCTGGACCC
TCTGCTCACAGAGGTGAGTGCGTGCTGGGCAAAGGTTTTAAATTTGGCTCCAAGGAAAGC
ATAGAGGATGGGGTTCAGACAACAGTGGAAGAAAGCTAAGCCCCTCGTGATGGAAATCCA
CTTGTGCACAGGGTTCTCAAACTCACACCCTTGCTTGATGATTCCCAGNAGGATGAAGGA
GTCAATGCTGATCCCAATGTANTAAGGCAGCCAACCAGCGAAAAAGCCAGGATGAAGATG
ACTGTGGTCTTGAG
Restriction Sites NotI-NotI |
ACCN NM_003467
Insert Size 1720 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_003467.2, NP_003458.1
RefSeq Size 1691 bp
RefSeq ORF 1059 bp
Locus ID 7852
UniProt ID P61073
Cytogenetics 2q22.1
Domains 7tm_1
Protein Families Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
Protein Pathways Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Leukocyte transendothelial migration
Summary This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. provided by RefSeq, Jul 2008
Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
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Documents
Resources
"NM_003467" in other vectors (6)
SKU Description Size Price
RC202069 CXCR4 (Myc-DDK-tagged)-Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2 10 ug
$686.00
RC202069L1 Lenti ORF clone of Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, Myc-DDK-tagged 10 ug
$986.00
RC202069L2 Lenti ORF clone of Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, mGFP tagged 10 ug
$986.00
RC202069L3 Lenti ORF clone of Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, Myc-DDK-tagged 10 ug
$986.00
RC202069L4 Lenti ORF clone of Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2, mGFP tagged 10 ug
$986.00
RG202069 CXCR4 (tGFP-tagged) - Human chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 2 10 ug
$489.00 $886.00

file-alt Citations

CXCR4 HAS THE POTENTIAL TO ENHANCE BONE FORMATION IN OSTEOPENIC RATS
Sanghani, Osagie-Clouard, Samizadeh et al
Tissue Eng Part A (2018)
AI Summary: OriGene’s pCMV-XL5-CXCR4 plasmid was used as the source of human CXCR4 cDNA for generating recombinant adenoviruses to transfect stem cells, enabling the investigation of CXCR4’s role in enhancing bone formation in osteopenic rats.
Snippet: Page 1. 1 Do Stem Cells Transfected with CXCR4 Enhance Bone Formation in Osteoporosis? …September 2017 View as HTML;1.2.3 Preparation of the recombinant adenoviruses The human CXCR4 cDNA (pCMV-XL5-CXCR4 Origene) was digested by restriction endonucleases NotI and XhoI and then inserted into pShuttle-CMV (AdEasy XL Adenoviral
Osteoporosis and ageing affects the migration of stem cells and this is ameliorated by transfection with CXCR4
Sanghani-Kerai, Coathup, Samazideh et al
Bone Joint Res (2017) 6 (6), 358-365 DOI: 10.1302/2046-3758.66.BJR-2016-0259.R1
AI Summary: OriGene’s human CXCR4 cDNA (pCMV-XL5-CXCR4) was used in this study to enable overexpression of CXCR4 in mesenchymal stem cells, thereby enhancing their migration towards SDF-1 and demonstrating the potential to improve stem cell homing impaired by ageing and osteoporosis.
Snippet: The human CXCR4 cDNA (pCMV-XL5-CXCR4 Origene Technologies, Inc, Rockville, Maryland) was digested by restriction endonucleases NotI and XhoI (Fisher Scientific, Loughborough, United Kingdom) and then inserted into pShuttle-CMV (AdEasy XL Adenoviral Vector System;Stratagene, San Diego, California) to form pShuttle-CMV-CXCR4
FigureFigureFigure
CXCR4 Antagonists: A Screening Strategy for Identification of Functionally Selective Ligands
Castaldo, Benicchi, Otrocka et al
J Biomol Screen (2014)
Cited by 15
AI Summary: OriGene’s pCMV6-XL5-CXCR4 plasmid was used as the source of human CXCR4 cDNA for generating recombinant cell lines essential for the functional screening assays in this study.
Snippet: The pcDNA3.1–Hygro(-)CXCR4 plasmid was generated by cloning the human CXCR4 cDNA with a NotI (Life Technologies) restriction digestion from the pCMV6–XL5–CXCR4 plasmid (OriGene Technologies, Rockville, MD, USA) into the pcDNA3.1–Hygro(-) (Life ... Cite SaveSaving
Showing 1-3 of 3 papers.
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