ACOX2 (NM_003500) Human Untagged Clone

SKU SC117937

ACOX2 (untagged)-Human acyl-CoA oxidase 2, branched chain (ACOX2)

Product Data

• Type: Human Untagged Clone
• Target Symbol: ACOX2
• Synonyms: BCOX; BRCACOX; BRCOX; CBAS6; THCCox
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117937 sequence for NM_003500 edited (data generated by NextGen Sequencing); ATGGGCAGCCCAGTGCACCGATTGTCATTGGGGGATACCTGGAGCAGGCAAATGCACCCC; GACATAGAGAGCGAGAGGTATATGCAGTCCTTTGACGTGGAACGGCTCACCAACATCCTT; GATGGAGGTGCCCAGAACACTGCACTCCGCAGGAAAGTTGAGAGCATCATCCACAGTTAC; CCGGAGTTTAGCTGTAAGGACAATTATTTCATGACCCAGAATGAGCGTTATAAGGCTGCC; ATGCGGAGGGCATTCCACATCCGGTTGATAGCTCGGCGCCTGGGTTGGTTAGAAGATGGT; CGTGAATTAGGCTACGCTTACAGAGCCCTTTCTGGAGACGTGGCCTTAAATATACACAGA; GTCTTCGTGAGAGCCCTCAGGAGCCTGGGCTCAGAGGAGCAGATTGCCAAATGGGACCCA; CTCTGCAAAAACATCCAGATCATCGCAACGTATGCACAGACAGAGTTGGGACATGGGACA; TATCTTCAGGGCCTGGAGACTGAAGCCACCTATGACGCAGCCACCCAGGAGTTTGTGATA; CACAGCCCCACGCTGACTGCCACCAAATGGTGGCCTGGAGACTTGGGACGGTCAGCCACC; CATGCCCTGGTCCAGGCCCAGCTGATCTGCTCAGGAGCCAGGCGGGGCATGCACGCTTTT; ATTGTGCCAATCCGGAGTCTTCAGGACCACACCCCACTGCCAGGAATCATCATTGGGGAC; ATCGGACCCAAGATGGACTTTGATCAAACAGACAATGGCTTCCTGCAGCTGAACCATGTG; CGGGTCCCCAGGGAGAACATGCTGAGTCGCTTTGCACNGGTCTTGCCAGATGGCACCTAC; GTCAAACTCGGTACAGCACAGAGCAACTACCTTCCCATGGTGGTGGTGCGGGTGGAGCTG; CTGTCAGGGGAGATCCTCCCTATACTGCAGAAGGCCTGTGTCATCGCCATGCGCTACTCG; GTCATCCGCCGCCAATCCCGGCTCCGGCCCAGTGACCCAGAGGCAAAGGTCCTGGACTAC; CAGACACAACAGCAGAAACTCTTTCCTCAGCTGGCCATCAGTTATGCCTTCCATTTCCTG; GCAGTCAGCCTCTTGGAGTTCTTCCAGCACTCCTACACTGCCATTCTGAACCAAGACTTC; AGCTTCCTGCCTGAGCTCCACGCACTGAGCACGGGCATGAAGGCCATGATGTCAGAATTC; TGCACCCAGGGAGCTGAGATGTGCCGCAGGGCCTGTGGCGGACATGGCTACTCAAAGCTG; AGTGGCCTGCCATCACTGGTCACCAAATTGTCGGCCTCCTGTACCTACGAGGGTGAGAAC; ACAGTGCTCTACCTGCAGGTGGCCAGGTTCCTGGTGAAGAGCTACCTGCAGACTCAGATG; TCCCCTGGCTCCACGCCACAGAGATCTCTCTCTCCATCTGTCGCATATCTCACCGCACCT; GACCTGGCCAGGTGTCCAGCCCAGAGGGCAGCCGACTTCCTCTGCCCGGAGCTCTACACC; ACGGCCTGGGCACATGTGGCAGTAAGGCTCATAAAGGACTCAGTGCAGCATTTACAGACC; CTGACGCAATCCGGAGCTGACCAGCACGAGGCTTGGAACCAGACCACTGTCATACACCTC; CAGGCTGCTAAGGTGCACTGCTACTATGTCACTGTGAAGGGTTTTACAGAAGCTCTGGAG; AAACTAGAAAATGAACCAGCGATTCAGCAGGTGCTCAAGCGCCTCTGTGACCTCCATGCC; ATACATGGAATCTTGACTAACTCGGGTGACTTTCTCCATGACGCCTTCCTGTCTGGTGCC; CAAGTGGACATGGCAAGAACAGCCTACCTGGACCTGCTCCGCCTGATCCGGAAGGATGCC; ATCCTGTTAACTGATGCTTTTGACTTCACCGATCAGTGTTTAAATTCAGCACTTGGCTGT; TATGATGGAAACGTCTACGAACGCCTGTTCCAGTGGGCTCAGAAGTCACCAACCAATACT; CAGGAGAACCCTGCCTATGAGGAATATATAAGACCACTTTTACAAAGTTGGAGATCCAAG; CTATGA; ; Clone variation with respect to NM_003500.3; 22 g=>t;818 a=>n
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003500 unedited; CTTTTGTATACGACTCACTATAGGGCGGCCGCGATTCGGCACGAGGCACAAGCCTGCCAG; AGGCTGCGGCCTACAGCCGGGGAGAGGCCAGCCCGGCCTACAGTGCGGACACAGGACAGA; GGGGAGCCAGGTTCTTTGCACTGACCAATGCTGAGAGCAGACCCTCGGAGCAGCCGGGTT; GGAAGTGTCTCTCCACAGTCACCAGACAGATCCAGGATAGGATGGGCAGCCCAGTGCACC; GATTGTCATTGGGGGATACCTGGAGCAGGCAAATGCACCCCGACATAGAGAGCGAGAGGT; ATATGCAGTCCTTTGACGTGGAACGGCTCACCAACATCCTTGATGGAGGTGCCCAGAACA; CTGCACTCCGCAGGAAAGTTGAGAGCATCATCCACAGTTACCCGGAGTTTAGCTGTAAGG; ACAATTATTTCATGACCCAGAATGAGCGTTATAAGGCTGCCATGCGGAGGGCATTCCACA; TCCGGTTGATAGCTCGGCGCCTGGGTTGGTTAGAAGATGGTCGTGAATTAGGCTACGCTT; ACAGAGCCCTTTCTGGAGACGTGGCCTTAAATATACACAGAGTCTTCGTGAGAGCCCTCA; GGAGCCTGNGCTCAGAGGAGCAGATTGCCAAATGGGACCCACTCTGCAAAAACATCCAGA; TCATCGCAACGTATGCACAGACAGAGTTGGGACATGGGACATATCTTCAGGGCCTGGAGA; CTGAAGCCACCTATGACGCAGCCACCCAGGAGTTTGTGATACACAGCCCCACGCTGACTG; CCACCAAATGGTGGCCTGGAGACTTNGGACGGTCAGCCACCCATGCCCTGNTCCCAGCCC; AGCTGATCTGCTCNAGAGCCAGCGGNGCATGCACGCCTTTATGTGCCATTCCGAGTCTTC; AGACACCCCCACTGCAGAATATCATGGGGACTCGNCCCAGAGGACTTGTCAACAGAATGG; CTTCTGN;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003500 unedited; CCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT; CTAATTAAAAATTTTAATGTTGCATATATGCCATAGTACCATTATCACATGATGGGGCTG; GTTGCTTCTTGAATACTGTGGGTTATTTCATAGCTTGGATCTCCAACTTTGTAAAAGGGG; TCTTATATATTCCTCATAGGCAGGGTTCTCCTGAGTATTGGTTGGGGACTTCTGAGCCCA; CTGGAACAGGCGTTCGTAAACGTTTCCATCATAACAGCCAAGTGCTGAATTTAAACACTG; ATCGGGGAAGTCAAAAGCATCAGTTAACAGGATGGCATCCTTCCGGATCAGGCGGAGCAG; GTCCAGGTAGGCTGTTCTTGCCATGTCCACTTGGGCACCAAACAGGAAGGCGTCATGGAA; AAAGTCACCCGAGTTAGTCAAGATTCCATGTATGGCATGGAGGTCACAAAGGCGCTTGAG; CACCTGCTGAATCGCTGGTTCATTTTCTAGTTTCTCCAGAGCTTCTGTAAAACCCTTCAC; AGTGACATAGTAGCAGTGCACCTTACCAGCCTGGAGGTGTATGACAGTGGTCTGGTTCCA; AGCCTCGTGCTGGTCAGCTCCGGATTGCGTCAGGGTCTGTAAATGCTGCACTGAGTCCTT; TATGAGCCTTACTGCCACATGTGCCCCAGGCCGTGGTGTAAAGCTCCGGGCAGAGGAAAG; TCGCTGCCCTCTGGGCTGGACACCTGCCCAGNTCAGGTGCGGTGAGATTGCGACAGATGG; AAGAGAGATTCTGTGGCGTGGAGCCAGGGACATCTGAGTCTGCAGTACTCTCACCAGACC; CTGCCCCTGCAGTAGACACTGGGTCTCACCTGTAATACAGGAGCCGACAATTGTGACATG; GATGCAGCCCTCACCTGGATAACATGCCGCCCAGC;
• Restriction Sites: NotI-NotI
• ACCN: NM_003500
• Insert Size: 2890 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003500.2, NP_003491.1
• RefSeq Size: 2343 bp
• RefSeq ORF: 2046 bp
• Locus ID: 8309
• UniProt ID: Q99424
• Cytogenetics: 3p14.3
• Domains: ACOX, Acyl-CoA_dh
• Protein Pathways: Metabolic pathways, PPAR signaling pathway, Primary bile acid biosynthesis
• Summary: The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009]