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eIF3s8 (EIF3C) (NM_003752) Human Untagged Clone

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SKU
SC117806
EIF3C (untagged)-Human eukaryotic translation initiation factor 3, subunit C (EIF3C), transcript variant 1
  $837.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol eIF3s8
Synonyms eIF3-p110; EIF3CL; EIF3S8
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC117806 sequence for NM_003752 edited (data generated by NextGen Sequencing)
ATGTCGCGGTTTTTCACCACCGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGAG
GAGCTCGTCACCAAACCTGTCGGAGGCAACTATGGCAAACAGCCATTGTTGCTGAGCGAG
GATGAAGAAGATACCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAGGAGCTG
ACCAACCTTATCCGGACCATCCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCTG
GAAGAGTTTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGCATTGTGGACAAAGAA
GGTGTCCCCCGGTTCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAATGAGCTT
TGGGAAGATAAGGAAGGGAAGAAGAAGATGAACAAGAACAATGCCAAGGCTCTGAGCACC
TTGCGTCAGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCACAAGCTACAAG
CAGAACCCCGAGCAGTCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCAGAAGGC
TCTTCAGATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAACTTTCTTGAAGAAGAAA
TCAGAAGCTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGATGAAGATGAG
GACTCAGAAGATTCCGAAGATGATGAAGACTGGGACACAGGTTCCACATCTTCCGATTCC
GACTCAGAGGAGGAAGAAGGGAAACAAACCGCGCTGGCCTCAAGATTTCTTAAAAAGGCA
CCCACCACAGATGAGGACAAGAAGGCAGCCGAGAAGAAACGGGAGGACAAAGCTAAGAAG
AAGCACGACAGGAAATCCAAGCGCCTGGATGAGGAGGAGGAGGACAATGAAGGCGGGGAG
TGGGAAAGGGTCCGGGGCGGAGTGCCGTTGGTTAAGGAGAAGCCAAAAATGTTTGCCAAG
GGAACTGAGATCACCCATGCTGTTGTTATCAAGAAACTGAATGAGATCCTACAGGCACGA
GGCAAGAAGGGAACTGATCGTGCTGCCCAGATTGAGCTGCTGCAACTGCTGGTTCAGATT
GCAGCGGAAAACAACCTGGGAGAGGGCGTCATTGTCAAGATCAAGTTCAATATCATCGCC
TCTCTCTATGACTACAACCCCAATCTGGCAACCTACATGAAGCCAGAGATGTGGGGGAAG
TGCCTGGACTGCATCAATGAGCTGATGGATATCCTGTTTGCAAATCCCAACATTTTTGTT
GGAGAGAATATTCTGGAAGAGAGTGAGAACCTGCACAACGCTGACCAGCCACTGCGTGTC
CGTGGCTGCATCCTAACTCTGGTGGAACGAATGGATGAAGAATTTACCAAAATAATGCAA
AATACTGACCCTCACTCCCAAGAGTACGTGGAGCACTTGAAGGATGAGGCCCAGGTGTGT
GCCATCATCGAGCGTGTGCAGCGCTACCTGGAGGAGAAGGGCACTACCGAGGAGGTCTGC
CGCATCTACCTGCTGCGCATCCTGCACACCTACTACAAGTTTGATTACAAGGCCCATCAG
CGACAGCTGACCCCGCCTGAGGGCTCCTCAAAGTCTGAGCAAGACCAGGCAGAAAATGAG
GGCGAGGACTCGGCTGTGTTGATGGAGAGACTGTGCAAGTACATCTACGCCAAGGACCGC
ACAGACCGGATCCGCACATGTGCCATCCTCTGCCACATCTACCACCATGCTCTGCACTCG
CGCTGGTACCAGGCCCGCGACCTCATGCTCATGAGCCACTTGCAGGACAACATTCAGCAT
GCAGACCCGCCAGTGCAGATCCTTTACAACCGCACCATGGTGCAGCTGGGCATCTGTGCC
TTCCGCCAAGGCCTGACCAAGGACGCACACAACGCCCTGCTGGACATCCAGTCGAGTGGC
CGAGCCAAGGAGCTTCTGGGCCAGGGCCTGCTGCTGCGCAGCCTGCAGGAGCGCAACCAG
GAGCAGGAGAAGGTGGAGCGGCGCCGTCAGGTCCCCTTCCACCTGCACATCAACCTGGAG
CTGCTGGAGTGTGTCTACCTGGTGTCTGCCATGCTCCTGGAGATCCCCTACATGGCCGCC
CATGAGAGCGATGCCCGCCGACGCATGATCAGCAAGCAGTTCCACCACCAGCTGCGCGTG
GGCGAGCGACAGCCCCTGCTGGGTCCCCCTGAGTCCATGCGGGAACATGTGGTCGCTGCC
TCCAAGGCCATGAAGATGGGTGACTGGAAGACCTGTCACAGTTTTATCATCAATGAGAAG
ATGAATGGGAAAGTGTGGGACCTTTTCCCCGAGGCTGACAAAGTCCGCACCATGCTGGTT
AGGAAGATCCAGGAAGAGTCACTGAGGACCTACCTCTTCACCTACAGCAGTGTCTATGAC
TCCATCAGCATGGAGACGCTGTCAGACATGTTTGAGCTGGATCTGCCCACTGTGCACTCC
ATCATCAGCAAAATGATCATTAATGAGGAGCTGATGGCCTCCCTGGACCAGCCAACACAG
ACAGTGGTGATGCACCGCACTGAGCCCACTGCCCAGCAGAACCTGGCTCTGCAGCTGGCC
GAGAAGCTGGGCAGCCTGGTGGAGAACAACGAACGGGTGTTTGACCACAAGCAGGGCACC
TACGGGGGCTACTTCCGAGACCAGAAGGACGGCTACCGCAAAAACGAGGGCTACATGCGC
CGCGGTGGCTACCGCCAGCAGCAGTCTCAGACGGCCTACTGA

Clone variation with respect to NM_003752.3
1164 c=>t
5' Read Nucleotide Sequence
>OriGene 5' read for NM_003752 unedited
GGGTTCAGNATTTGTAAACGATTCACTATAGGCGGCCCGCGAATTCGCACGAGGGCCCTG
CGGTGTGACTCGCGGGCTCAGCTGGTCCGGCCGTAGCACCTCCGCGCCGTCGCCATGTCG
CGGTTTTTCACCACCGGTTCGGACAGCGAGTCCGAGTCGTCCTTGTCCGGGGAGGAGCTC
GTCACCAAACCTGTCGGAGGCAACTATGTTTTTTGCCATTGTTGCTGAGCGAGGATGAAG
AAGATACCAAGAGAGTTGTCCGCAGTGCCAAGGACAAGAGGTTTGAGGAGCTGACCAACC
TTATCCGGACCATCCGTAATGCCATGAAGATTCGTGATGTCACCAAGTGCCTGGAAGAGT
TTGAGCTCCTGGGAAAAGCATATGGGAAGGCCAAAAGCATTGTGGACAAAGAAGGTGTCC
CCCGGTTCTATATCCGCATCCTGGCTGACCTAGAGGACTATCTTAATGAGCTTTGGGAAG
ATAAGGAAGGGAAGAAGAAGATGAACAAGAACAATGCCAAGGCTCTGAGCACCTTGCGTC
AGAAGATCCGAAAATACAACCGTGATTTCGAGTCCCATATCACAAGCTACAAGCAGAACC
CCGAGCAGTCTGCGGATGAAGATGCTGAGAAAAATGAGGAGGATTCAGAAGGCTCTTCAG
ATGAGGATGAGGATGAGGACGGAGTCAGTGCTGCAACTTTCTTGAAGAAGAAATCACAAG
CTCCTTCTGGGGAGAGTCGCAAGTTCCTCAAAAAGATGGATGATGAAGATGACGACTCAG
AAGATCCCGAGATGATGAAGACTGGGACACAGTTTCCCATCTTCCGATTCCGACTTCATA
GGAGAAGTAGGGAACCAACCGCGCCTGCCTCAGATTTCTTAAAAGCCCCCCCACGAGGAG
ACAG
3' Read Nucleotide Sequence
>OriGene 3' read for NM_003752 unedited
NNCCAAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCAAC
TTTAAACAGACCTTTAGTGACTGAGGTGTGGTTTAGGACTTCAAGGTTGGATGGCCCAGG
CGGGAAACAGAGTGGAGAGCTCAGTAGGCCGTCTGAGACTGCTGCTGGCGGTAGCCACCG
CGGCGCATGTAGCCCTCGTTTTTGCGGTAGCCGTCCTTCTGGTCTCGGAAGTAGCCCCCG
TAGGTGCCCTGCTTGTGGTCAAACACCCGTTCGTTGTTCTCCACCAGGCTGCCCAGCTTC
TCGGCCAGCTGCAGAGCCAGGTTCTGCTGGGCAGTGGGCTCAGTGCGGTGCATCACCACT
GTCTGTGTTGGCTGGTCCAGGGAGGCCATCAGCTCCTCATTAATGATCATTTTGCTGATG
ATGGAGTGCACAGTGGGCAGATCCAGCTCAAACATGTCTGACAGCGTCTCCATGCTGATG
GAGTCATAGACACTGCTGTACGTGAAGAGGTAGGTCCTCAGTGACTCTTCCTGGATCTTC
CTAACCAGCATGGTGCGGACTTTGTCAGCCTCGGGGAAAAGGTCCCACACTTTCCCATTC
ATCTTCTTATTGATGATAAAACTGCGACAGGTCTTCCAGTCACCCATCTTCATGGCCTTG
GAGGCCGCGACCACATGTTCCCGCATGGACTCAAGTGGACCCAGCATGGGCTGTCGCTTG
CCCACGCGCAGCTGCCGGTGGAACTGCTTGCTGATCATTCGTCCGCGGGCATCGCTCTCA
TGGGCGGCCATGTACGGGATCTCCAGGAGCCTGGCAGACCCAGGGTGAAACACTCCAGCC
TTCCAGTTGATGTGTAAGTTGTATGGGAACTGTACGGGCCGTTTCACCTTCTT
Restriction Sites NotI-NotI |
ACCN NM_003752
Insert Size 3000 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_003752.2, NP_003743.1
RefSeq Size 3027 bp
RefSeq ORF 2742 bp
Locus ID 8663
UniProt ID Q99613
Cytogenetics 16p11.2
Domains PCI
Protein Families Druggable Genome
Summary Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (1) is the predominant transcript. Variants 1-4 encode the same isoform (a).
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Documents
Resources
"NM_003752" in other vectors (6)
SKU Description Size Price
RC221404 EIF3C (Myc-DDK-tagged)-Human eukaryotic translation initiation factor 3, subunit C (EIF3C), transcript variant 1 10 ug
$836.00
RC221404L1 Lenti ORF clone of Human eukaryotic translation initiation factor 3, subunit C (EIF3C), transcript variant 1, Myc-DDK-tagged 10 ug
$1,136.00
RC221404L2 Lenti ORF clone of Human eukaryotic translation initiation factor 3, subunit C (EIF3C), transcript variant 1, mGFP tagged 10 ug
$1,136.00
RC221404L3 Lenti ORF clone of Human eukaryotic translation initiation factor 3, subunit C (EIF3C), transcript variant 1, Myc-DDK-tagged 10 ug
$1,136.00
RC221404L4 Lenti ORF clone of Human eukaryotic translation initiation factor 3, subunit C (EIF3C), transcript variant 1, mGFP tagged 10 ug
$1,136.00
RG221404 EIF3C (tGFP-tagged) - Human eukaryotic translation initiation factor 3, subunit C (EIF3C), transcript variant 1 10 ug
$789.00 $1,036.00

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