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WAVE 1 (WASF1) (NM_003931) Human Untagged Clone

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SKU
SC117699
WASF1 (untagged)-Human WAS protein family, member 1 (WASF1), transcript variant 1
  $521.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol WAVE 1
Synonyms NEDALVS; SCAR1; WAVE; WAVE1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC117699 sequence for NM_003931 edited (data generated by NextGen Sequencing)
ATGCCGCTAGTGAAAAGAAACATCGATCCTAGGCACTTGTGCCACACAGCACTGCCTAGA
GGCATTAAGAATGAACTGGAATGTGTAACCAATATTTCCTTGGCAAATATAATTAGACAA
CTAAGTAGCCTAAGTAAATATGCTGAAGATATATTTGGAGAATTATTCAATGAAGCACAT
AGTTTTTCCTTCAGAGTCAACTCATTGCAAGAACGTGTGGACCGTTTATCTGTTAGTGTT
ACACAGCTTGATCCAAAGGAAGAAGAATTGTCTTTGCAAGATATAACAATGAGGAAAGCT
TTCCGAAGTTCTACAATTCAAGACCAGCAGCTTTTCGATCGCAAGACTTTGCCTATTCCA
TTACAGGAGACGTACGATGTTTGTGAACAGCCTCCACCTCTCAATATACTCACTCCTTAT
AGAGATGATGGTAAAGAAGGTCTGAAGTTTTATACCAATCCTTCGTATTTCTTTGATCTA
TGGAAAGAAAAAATGTTGCAAGATACAGAGGATAAGAGGAAGGAAAAGAGGAAGCAGAAG
CAGAAAAATCTAGATCGTCCTCATGAACCAGAAAAAGTGCCAAGAGCACCTCATGACAGG
CGGCGAGAATGGCAGAAGCTGGCCCAAGGTCCAGAGCTGGCTGAAGATGATGCTAATCTC
TTACATAAGCATATTGAAGTTGCTAATGGCCCAGCCTCTCATTTTGAAACAAGACCTCAG
ACATACGTGGATCATATGGATGGATCTTACTCACTTTCTGCCTTGCCATTTAGTCAGATG
AGTGAGCTTCTGACTAGAGCTGAGGAAAGGGTATTAGTCAGACCACATGAACCACCTCCA
CCTCCACCAATGCATGGAGCAGGAGATGCAAAACCGATACCCACCTGTATCAGTTCTGCT
ACAGGTTTGATAGAAAATCGCCCTCAGTCACCAGCTACAGGCAGAACACCTGTGTTTGTG
AGCCCCACTCCCCCACCTCCTCCACCACCTCTTCCATCTGCCTTGTCAACTTCCTCATTA
AGAGCTTCAATGACTTCAACTCCTCCCCCTCCAGTACCTCCCCCACCTCCACCTCCAGCC
ACTGCTTTGCAAGCTCCAGCAGTACCACCACCTCCAGCTCCTCTTCAGATTGCCCCTGGA
GTTCTTCACCCAGCTCCTCCTCCAATTGCACCTCCTCTAGTACAGCCCTCTCCACCAGTA
GCTAGAGCTGCCCCAGTATGTGAGACTGTACCAGTTCATCCACTCCCACAAGGTGAAGTT
CAGGGGCTGCCTCCACCCCCACCACCGCCTCCTCTGCCTCCACCTGGCATTCGACCATCA
TCACCTGTCACAGTTACAGCTCTTGCTCATCCTCCCTCTGGGCTACATCCAACTCCATCT
ACTGCCCCAGGTCCCCATGTTCCATTAATGCCTCCATCTCCTCCATCACAAGTTATACCT
GCTTCTGAGCCAAAGCGCCATCCATCAACCCTACCTGTAATCAGTGATGCCAGGAGTGTG
CTACTGGAAGCAATACGAAAAGGTATTCAGCTACGCAAAGTAGAAGAGCAGCGTGAACAG
GAAGCTAAGCATGAACGCATTGAAAACGATGTTGCCACCATCCTGTCTCGCCGTATTGCT
GTTGAATATAGTGATTCGGAAGATGATTCAGAATTTGATGAAGTAGATTGGTTGGAGTAA

Clone variation with respect to NM_003931.2
5' Read Nucleotide Sequence
>OriGene 5' read for NM_003931 unedited
NGGGTCGTTTTTGTATACGACTCCTATAGGCGGCCGCGNATTCGGCACGAGGCTAGCTTC
GGTACTCTGACACCTTCTCTTGCACTTGCGGATGATGAACTGGAATAACGATGAAAGAAA
GCACATCCGATCTCAACATTCACGTCCTGCCCTATAACCGATTAATTAATTGATCCCCAG
CTAGACTAGTGTTGGAGAAATCAGCATGTTAAAACAACTGTTGATGATAGCTGTTGGAGT
AAAGTTGCAGTGGAAGCTATGGCTGCAAAATCGTTAAAATCTTCAAGGTGAACTGGCACA
AAGGTTAATCTCAAGATGCCGCTAGTGAAAAGAAACATCGATCCTAGGCACTTGTGCCAC
ACAGCACTGCCTAGAGGCATTAAGAATGAACTGGAATGTGTAACCAATATTTCCTTGGCA
AATATAATTAGACAACTAAGTAGCCTAAGTAAATATGCTGAAGATATATTTGGAGAATTA
TTCAATGAAGCACATAGTTTTTCCTTCAGAGTCAACTCATTGCAAGAACGTGTGGACCGT
TTATCTGTTAGTGTTACACAGCTTGATCCAAAGGAAGAAGAATTGTCTTTGCAAGATATA
ACAATGAGGAAAGCTTTCCGAAGTTCTACAATTCAAGACCAGCAGCTTTTCGATCGCAAG
ACTTTGCCTATTCCATTACAGGAGACGTACGATGTTTGTGAACAGCCTCCACCTCTCAAT
ATACTCACTCCTTATAGAGATGATGGTAANAGAAGGTTCTGAAGTTNTATACCAATCCTT
CGTATTTCTTTGATCTATGGAAAGAANNAATGTTGCAAGATACAGNAGGATAGAGGAAGG
NAAAGAGGAAGCAGAAGCAGAAAATTCTAGATCGTCCTCATGAACCAGNANAAGTGCCAG
AGCACCTC
3' Read Nucleotide Sequence
>OriGene 3' read for NM_003931 unedited
TGGACCGGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTAACTTTTAAAA
TGAACCATTTATTAAATCAGACTGTTATTCTTAACAGTTATGTAAGTTACATGTATGTTT
AAGTCAGAGTATTTCACATGGAAAAGTTTTTAACTCCTATAGGCAAGCAAAATCATATCA
CACAATATATAAGTGGGAAGGGGATACTGCTAAACATTCAAATAAGGCAAGTATATAAAA
ACAATAAAACAATAATGAAAAAATTCAAGCATTCCTTTAAGAGAATTCAACACTACAAGC
TAAATGTACTTTCTGAGTGTATTCGTATAATCAAGGCAGTGTTTCTTCTTTTAAAACATC
AGGAAATGGAATAAGGCTCATTAGTAGATACAGCTGCCCTCAAGATTTCAATTTCAGTTG
CTTTCTTTAAATTAAAATTCACAAAGTACACAATTAAGATATATCAAAAAACTGAATCTG
CTACTCTAACAACAGCTGTCCATGCTTAATACTTAGTGGTTTATTTGACCAAATTAGTCT
TTTCAGGGGGAAAAAAAGATAAGCCACTGTAAAACATTCAGTTTGAAATGTATGCTAATA
TTTTCCTTAAAAATCAAAAGTTATGGAGGAAAAGGGTCATTTATTATAAGGAAAAGAAAG
CCAAACACTATAATGACCCAACATTTTCCAGGAACAAGCACCCCAAAGGACATTTGCATT
CACCTTTGCAATATTATCAATGCCTTTTTCTTACTCCACCAATCTACTTCATCAAATTCT
GAAACCTCTTCCGAAATACTATTTTCAACAGCTATACCGGTGAAACCAGGATGGTGGCCA
CCATCGTCTCCAAAGGCCTCCATGCCTTACCTTCCTGTTCACCCTCGTTTTTTTATTTTG
Restriction Sites NotI-NotI |
ACCN NM_003931
Insert Size 2620 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_003931.2, NP_003922.1
RefSeq Size 3230 bp
RefSeq ORF 1680 bp
Locus ID 8936
UniProt ID Q92558
Cytogenetics 6q21
Domains WH2
Protein Families Druggable Genome
Protein Pathways Adherens junction, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton
Summary The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. provided by RefSeq, Jul 2008
Transcript Variant: This variant (1) represents the longest transcript.
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Documents
Resources
"NM_003931" in other vectors (6)
SKU Description Size Price
RC216977 WASF1 (Myc-DDK-tagged)-Human WAS protein family, member 1 (WASF1), transcript variant 1 10 ug
$520.00
RC216977L1 Lenti ORF clone of Human WAS protein family, member 1 (WASF1), transcript variant 1, Myc-DDK-tagged 10 ug
$820.00
RC216977L2 Lenti ORF clone of Human WAS protein family, member 1 (WASF1), transcript variant 1, mGFP tagged 10 ug
$820.00
RC216977L3 Lenti ORF clone of Human WAS protein family, member 1 (WASF1), transcript variant 1, Myc-DDK-tagged 10 ug
$820.00
RC216977L4 Lenti ORF clone of Human WAS protein family, member 1 (WASF1), transcript variant 1, mGFP tagged 10 ug
$820.00
RG216977 WASF1 (tGFP-tagged) - Human WAS protein family, member 1 (WASF1), transcript variant 1 10 ug
$489.00 $720.00

file-alt Citations

Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel
Karpushev, Levchenko, Ilatovskaya et al
Hypertension (2011) 57 (5), 996-1002 DOI: 10.1161/HYPERTENSIONAHA.110.157784
AI Summary: In this study, OriGene products—including anti-WAVE1 and anti-WAVE2 antibodies—were used to detect and localize WAVE1 and WAVE2 proteins, helping to demonstrate their role in Rac1-mediated regulation of the epithelial Na+ channel (ENaC).
Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel
Karpushev, Levchenko, Ilatovskaya et al
Hypertension (2011) 57 (5), 996-1002 DOI: 10.1161/HYPERTENSIONAHA.110.157784
Cited by 11
AI Summary: OriGene products, specifically shRNA constructs targeting WAS protein family members WASF1 (SC117699), WASF2 (SC126670), WASF3 (SC115933), and Wiskott-Aldrich syndrome-like (SC111092), were used in this study to investigate the role of WAVE proteins in Rac1-mediated regulation of the epithelial Na+ channel (ENaC).
Snippet: syndrome-like (SC111092), WAS protein family, member 1 (WASF1) (SC117699), WASF2 (SC126670), and WASF3 (SC115933) were from OriGene (Rockville, MD). ... B, Densitometric analysis of relative Rac1 protein expression in control and Rac1 knocked-down (KD) M-1 cells
Rac1 regulates neuronal polarization through the WAVE complex
Tahirovic, Hellal, Neukirchen et al
J Neurosci (2010) 30 (20), 6930-43 DOI: 10.1523/JNEUROSCI.5395-09.2010
AI Summary: In this study, OriGene’s anti-Rac1 antibody (Cat# TA190084) was used to detect Rac1 protein levels, contributing to the analysis of Rac1 expression and its role in neuronal polarization.
Showing 1-3 of 3 papers.
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