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ROR1 (NM_005012) Human Untagged Clone

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SKU
SC117005
ROR1 (untagged)-Human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1
  $1,288.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol ROR1
Synonyms dJ537F10.1; NTRKR1
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF sequence for NM_005012 edited
ATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTG
CTGCTGGCCGCACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTA
GTGCCTACCTCATCATGGAACATCTCAAGTGAACTCAACAAAGATTCTTACCTGACCCTT
GATGAACCAATGAATAACATCACCACGTCTCTGGGCCAGACAGCAGAACTGCACTGCAAA
GTCTCTGGGAATCCACCTCCCACCATCCGCTGGTTCAAAAATGATGCTCCTGTGGTCCAG
GAGCCCCGGAGGCTCTCCTTTCGGTCCACCATCTATGGCTCTCGGCTGCGGATTAGAAAC
CTCGACACCACAGACACAGGCTACTTCCAGTGCGTGGCAACAAACGGCAAGGAGGTGGTT
TCTTCCACTGGAGTCTTGTTTGTCAAGTTTGGCCCCCCTCCCACTGCAAGTCCAGGATAC
TCAGATGAGTATGAAGAAGATGGATTCTGTCAGCCATACAGAGGGATTGCATGTGCAAGA
TTTATTGGCAACCGCACCGTCTATATGGAGTCTTTGCACATGCAAGGGGAAATAGAAAAT
CAGATCACAGCTGCCTTCACTATGATTGGCACTTCCAGTCACTTATCTGATAAGTGTTCT
CAGTTCGCCATTCCTTCCCTGTGCCACTATGCCTTCCCGTACTGCGATGAAACTTCATCC
GTCCCAAAGCCCCGTGACTTGTGTCGCGATGAATGTGAAATCCTGGAGAATGTCCTGTGT
CAAACAGAGTACATTTTTGCAAGATCAAATCCCATGATTCTGATGAGGCTGAAACTGCCA
AACTGTGAAGATCTCCCCCAGCCAGAGAGCCCAGAAGCTGCGAACTGTATCCGGATTGGA
ATTCCCATGGCAGATCCTATAAATAAAAATCACAAGTGTTATAACAGCACAGGTGTGGAC
TACCGGGGGACCGTCAGTGTGACCAAATCAGGGCGCCAGTGCCAGCCATGGAATTCCCAG
TATCCCCACACACACACTTTCACCGCCCTTCGTTTCCCAGAGCTGAATGGAGGCCATTCC
TACTGCCGCAACCCAGGGAATCAAAAGGAAGCTCCCTGGTGCTTCACCTTGGATGAAAAC
TTTAAGTCTGATCTGTGTGACATCCCAGCTTGCGATTCAAAGGATTCCAAGGAGAAGAAT
AAAATGGAAATCCTGTACATACTAGTGCCAAGTGTGGCCATTCCCCTGGCCATTGCTTTA
CTCTTCTTCTTCATTTGCGTCTGTCGGAATAACCAGAAGTCATCGTCGGCACCAGTCCAG
AGGCAACCAAAACACGTCAGAGGTCAAAATGTAGAGATGTCAATGCTGAATGCATATAAA
CCCAAGAGCAAGGCTAAAGAGCTACCTCTTTCTGCTGTACGCTTTATGGAAGAATTGGGT
GAGTGTGCCTTTGGAAAAATCTATAAAGGCCATCTCTATCTCCCAGGCATGGACCATGCT
CAGCTGGTTGCTATCAAGACCTTGAAAGACTATAACAACCCCCAGCAATGGATGGAATTT
CAACAAGAAGCCTCCCTAATGGCAGAACTGCACCACCCCAATATTGTCTGCCTTCTAGGT
GCCGTCACTCAGGAACAACCTGTGTGCATGCTTTTTGAGTATATTAATCAGGGGGATCTC
CATGAGTTCCTCATCATGAGATCCCCACACTCTGATGTTGGCTGCAGCAGTGATGAAGAT
GGGACTGTGAAATCCAGCCTGGACCACGGAGATTTTCTGCACATTGCAATTCAGATTGCA
GCTGGCATGGAATACCTGTCTAGTCACTTCTTTGTCCACAAGGACCTTGCAGCTCGCAAT
ATTTTAATCGGAGAGCAACTTCATGTAAAGATTTCAGACTTGGGGCTTTCCAGAGAAATT
TACTCCGCTGATTACTACAGGGTCCAGAGTAAGTCCTTGCTGCCCATTCGCTGGATGCCC
CCTGAAGCCATCATGTATGGCAAATTCTCTTCTGATTCAGATATCTGGTCCTTTGGGGTT
GTCTTGTGGGAGATTTTCAGTTTTGGACTCCAGCCATATTATGGATTCAGTAACCAGGAA
GTGATTGAGATGGTGAGAAAACGGCAGCTCTTACCATGCTCTGAAGACTGCCCACCCAGA
ATGTACAGCCTCATGACAGAGTGCTGGAATGAGATTCCTTCTAGGAGACCAAGATTTAAA
GATATTCACGTCCGGCTTCGGTCCTGGGAGGGACTCTCAAGTCACACAAGCTCTACTACT
CCTTCAGGGGGAAATGCCACCACACAGACAACCTCCCTCAGTGCCAGCCCAGTGAGTAAT
CTCAGTAACCCCAGATATCCTAATTACATGTTCCCGAGCCAGGGTATTACACCACAGGGC
CAGATTGCTGGTTTCATTGGCCCGCCAATACCTCAGAACCAGCGATTCATTCCCATCAAT
GGATACCCAATACCTCCTGGATATGCAGCGTTTCCAGCTGCCCACTACCAGCCAACAGGT
CCTCCCAGAGTGATTCAGCACTGCCCACCTCCCAAGAGTCGGTCCCCAAGCAGTGCCAGT
GGGTCGACTAGCACTGGCCATGTGACTAGCTTGCCCTCATCAGGATCCAATCAGGAAGCA
AATATTCCTTTACTACCACACATGTCAATTCCAAATCATCCTGGTGGAATGGGTATCACC
GTTTTTGGCAACAAATCTCAAAAACCCTACAAAATTGACTCAAAGCAAGCATCTTTACTA
GGAGACGCCAATATTCATGGACACACCGAATCTATGATTTCTGCAGAACTGTAA
5' Read Nucleotide Sequence
>OriGene 5' read for NM_005012 unedited
ATCCTTCCCGCCCGTTGCCGCATTGGGCGGTAGGCGTGTACGGTGGGAAGGTCTATATAA
GCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCG
CGAATTCGGCACGAGGGAGCGTGGAGAGCTGGAGCAGCCGCCACCGCCGCCGCCGAGGGA
GCCCCGGGACGGCAGCCCCTGGGCGCAGGGTGCGCTGTTCTCGGAGTCCGACCCAGGGCG
ACTCACGCCCACTGGTGCGACCCGGACAGCCTGGGACTGACCCGCCGGCCCAGGCGAGGC
TGCAGCCAGAGGGCTGGGAAGGGATCGCGCTCGCGGCATCCAGAGGCGGCCAGGCGGAGG
CGAGGGAGCAGGTTAGAGGGACAAAGAGCTTTGCAGACGTCCCCGGCGTCCTGCGAGCGC
CAGCGGCCGGGACGAGGCGGCCGGGAGCCCGGGAAGAGCCCGTGGATGTTCTGCGCGCGG
CCTGGGAGCCGCCGCCGCCGCCGCCTCAGCGAGAGGAGGAATGCACCGGCCGCGCCGCCG
CGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCGCACGCGGAGC
TGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAA
CATCTCAAGTGAACTCAACANAGATTCTTACCTGACCCTTGATGAACCAATGAATAACAT
CACCACGTCTCTAGGCCAGACAGCAGAACTGCACTGCANAGTCTCTGGGAATCCACNNCT
CCACATCCGCTGGGTCAAAAATGATGCTCCTGTGGTCCAGGAGCCCCGGAGGGCTCTCTT
TCGTTCAACATCTATGGCTCTCGGCTGGCGGATTANAAACTCGACACCCCAGACCAAGCT
ACTTTCAGTGCGTGGCAACA
3' Read Nucleotide Sequence
>OriGene 3' read for NM_005012 unedited
AAATTCGCGGTGTCTGTCCCTGCTTGGTAAGACACATGNAACTTCACANAGGTACTTGTT
GCGATGTCTGCTAAATGAGAACCTTACTTTAATAAAAACATTTGAATATAAATCTTTTCT
ACGGCCGTCTAGTTTGTCCTGTATACCACATTTACAAAAGTTGTGCATTTTACAGTTCTG
CAGAAATCATAGATTCGGTGTGTCCATGAATATTGGCGTCTCCTAGTAAAGATGCTTGCT
TTGAGTCAATTTTGTAGGGTTTTTGAGATTTGTTGCCAACAACGGTGATACCCATTCCAC
CAGGATGATTTGGAATTGACATGTGTGGTAGTAAAGGAATATTTGCTTCCTGATTGGATC
CTGATGAGGGCAAGCTAGTCACATGGCCAGTGCTAGTCGACCCACTGGCACTGCTTGGGG
ACCGACTCTTGGGAGGTGGGCAGTGCTGAATCACTCTGGGAGGACCTGTTGGCTGGTAGT
GGGCAGCATGAAACGCTGCATATCCAGGAGGTATTGGGTATCCATTGATGGGAATGAATC
GCTGGTTCTGAGGTATTGGCGGGCCAATGAAACCAGCCATCTGGCCCTGTGGTGTAATAC
CCTGGCTCGGGAACATGTAATTAGGATATCTGGGGTTACTGAGATTACTCACTGNGCTGG
CACTGAGGGAGGTTGTCTGTGTGGTGGCATTTCCCCCTGAAGGAGTAGTAGAGCTTGTGT
GACTTGAGAGTCCCTNCCAGGACCGAAGCCCNACGTGAATATCTTTAAATCTTGGTCTTC
TAGAAGGAATCTCATTCCAGCACTCTGTCATTGAGCTGTACATTCTGGGTGGGCAGTCTT
CANAGCATGTTAAGAGCTGCCGNTTTCTCACCATCTCATCACTTTCTGGTTACTGAATCC
ATATTATGG
Restriction Sites NotI-NotI |
ACCN NM_005012
Insert Size 3500 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_005012.1, NP_005003.1
RefSeq Size 5871 bp
RefSeq ORF 2814 bp
Locus ID 4919
UniProt ID Q01973
Cytogenetics 1p31.3
Domains FRI, ig, IG, IGc2, KR, pkinase, S_TKc, TyrKc
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Summary This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Jun 2012
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because transcript sequence consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments.
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"NM_005012" in other vectors (7)
SKU Description Size Price
RC214967 ROR1 (Myc-DDK-tagged)-Human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1 10 ug
$1,287.00
RC214967L1 Lenti ORF clone of Human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1, Myc-DDK-tagged 10 ug
$1,587.00
RC214967L2 Lenti ORF clone of Human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1, mGFP tagged 10 ug
$1,587.00
RC214967L3 Lenti ORF clone of Human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1, Myc-DDK-tagged 10 ug
$1,587.00
RC214967L4 Lenti ORF clone of Human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1, mGFP tagged 10 ug
$1,587.00
RC600058 ROR1 (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens receptor tyrosine kinase-like orphan receptor 1, transcript variant 1, Signal peptide (1-29) plus EC domain (30-406) 10 ug
$289.00 $457.00
RG214967 ROR1 (tGFP-tagged) - Human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1 10 ug
$789.00 $1,487.00

file-alt Citations

Detecting Receptor Tyrosine Kinase ROR1 Using a Developed Anti-ROR1 Polyclonal Antibody
Hemmati, Hassannia, Milani et al
Monoclon Antib Immunodiagn Immunother (2018) 37 (1), 38-44 DOI: 10.1089/mab.2017.0059
Snippet: Materials and Methods. PCR amplification of ROR1 gene The extracellular region of human ROR1 protein, residues 30 through 406, (excluding signal sequence) was amplified from pCMV6-XL6-ROR1 plasmid (OriGene, Rockville, MD), which contains complete cDNA
Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia
Plešingerová, Janovská, Mishra et al
Haematologica (2017)
Cited by 30
AI Summary: OriGene’s pCMV6-XL6-ROR1 vector was used as the source for cloning ROR1, enabling the study of COBLL1 as a novel ROR1 binding partner and its prognostic significance in chronic lymphocytic leukemia.
Snippet: To prepare ROR1 - V5 vector, we cloned ROR1 from pCMV6 - XL6 - ROR1 vector (OriGene Technologies) into pcDNA3.1/V5 - His vector (Invitrogen)
Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis
Gentile, Lazzari, Benvenuti et al
Cancer Res. (2011) 71 (8), 3132-41 DOI: 10.1158/0008-5472.CAN-10-2662
Cited by 22
AI Summary: OriGene’s human full-length Ror1 cDNA (NM_005012.1) was used in this study to enable functional analyses of Ror1’s role in cancer cell proliferation and Met-driven tumorigenesis.
Snippet: Human full-length Ror1 cDNA (NM_005012.1) was purchased from Origene and was subsequently cloned in the pRRL2 lentiviral vector (12). ... As expected from the results of the screening, silencing Ror1 slowed down proliferation of HS746T and NCI-H1993, but not that
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
Fukuda, Chen, Endo et al
Proc Natl Acad Sci U S A (2008) 105 (8), 3047-52 DOI: 10.1073/pnas.0712148105
Cited by 315
AI Summary: OriGene products, specifically the ROR1 cDNA clone and ROR1 expression plasmids, were used in this study to express ROR1 in HEK293 cells, enabling the identification and functional analysis of ROR1 as an oncofetal antigen and receptor for Wnt5a in CLL.
Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia
Baskar, Kwong, Hofer et al
Clin Cancer Res (2008) 14 (2), 396-404 DOI: 10.1158/1078-0432.CCR-07-1823
AI Summary: In this study, OriGene’s anti-ROR1 antibody (catalog # TA301514) was used to detect and analyze the expression of ROR1 protein on B-CLL cells, enabling the identification of ROR1 as a uniformly and selectively expressed cell surface antigen in B-cell chronic lymphocytic leukemia.
Showing 1-5 of 5 papers.
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