HES1 (NM_005524) Human Untagged Clone
$450.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | HES1 |
| Synonyms | bHLHb39; HES-1; HHL; HRY |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_005524 |
| Insert Size | 1600 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005524.2, NP_005515.1 |
| RefSeq Size | 1471 bp |
| RefSeq ORF | 843 bp |
| Locus ID | 3280 |
| UniProt ID | Q14469 |
| Cytogenetics | 3q29 |
| Domains | HLH, ORANGE |
| Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transcription Factors |
| Protein Pathways | Maturity onset diabetes of the young, Notch signaling pathway |
| Summary | This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_005524" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC211709 | HES1 (Myc-DDK-tagged)-Human hairy and enhancer of split 1, (Drosophila) (HES1) | 10 ug |
$300.00
|
|
| RC211709L1 | Lenti ORF clone of Human hairy and enhancer of split 1, (Drosophila) (HES1), Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC211709L2 | Lenti ORF clone of Human hairy and enhancer of split 1, (Drosophila) (HES1), mGFP tagged | 10 ug |
$600.00
|
|
| RC211709L3 | Lenti ORF clone of Human hairy and enhancer of split 1, (Drosophila) (HES1), Myc-DDK-tagged | 10 ug |
$600.00
|
|
| RC211709L4 | Lenti ORF clone of Human hairy and enhancer of split 1, (Drosophila) (HES1), mGFP tagged | 10 ug |
$600.00
|
|
| RG211709 | HES1 (tGFP-tagged) - Human hairy and enhancer of split 1, (Drosophila) (HES1) | 10 ug |
$489.00
$500.00
|
|
Citations
Lutein inhibits proliferation, invasion and migration of hypoxic breast cancer cells via downregulation of HES1
Li, Zhang, Liu et al
Int J Oncol (2018)
Li, Zhang, Liu et al
Int J Oncol (2018)
Transcription Factors with Conserved Binding Sites Near ATOH1 on the POU4F3 Gene Enhance the Induction of Cochlear Hair Cells
Ikeda, Pak, Chavez et al
Mol. Neurobiol. (2014)
Ikeda, Pak, Chavez et al
Mol. Neurobiol. (2014)
Cited by 46
AI Summary: OriGene contributed to this study by providing all the plasmids used for transfection, including those encoding the transcription factors tested for their effects on cochlear hair cell induction.
Snippet: 2). All plasmids were purchased from OriGene (Rockville, MD, USA). Five days after transfection, GFP fluorescence was evaluated, and immunolabelling was carried out to detect myosin 7A+, which in the inner ear is a specific marker for the HC phenotype [18]. ... Cite SaveSaving
Showing 1-2 of 2 papers.
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