ELOC (NM_005648) Human Untagged Clone
SKU
SC116611
TCEB1 (untagged)-Human transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant 1
$150.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | ELOC |
| Synonyms | SIII; TCEB1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_005648 |
| Insert Size | 800 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_005648.2, NP_005639.1 |
| RefSeq Size | 668 bp |
| RefSeq ORF | 339 bp |
| Locus ID | 6921 |
| UniProt ID | Q15369 |
| Cytogenetics | 8q21.11 |
| Domains | Skp1 |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis |
| Summary | This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. provided by RefSeq, Mar 2011 Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-7 encode the same protein (isoform a). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_005648" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC201950 | TCEB1 (Myc-DDK-tagged)-Human transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant 1 | 10 ug |
$150.00
|
|
| RC201950L1 | Lenti ORF clone of Human transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant 1, Myc-DDK-tagged | 10 ug |
$450.00
|
|
| RC201950L2 | Lenti ORF clone of Human transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant 1, mGFP tagged | 10 ug |
$450.00
|
|
| RC201950L3 | Lenti ORF clone of Human transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant 1, Myc-DDK-tagged | 10 ug |
$450.00
|
|
| RC201950L4 | Lenti ORF clone of Human transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant 1, mGFP tagged | 10 ug |
$450.00
|
|
| RG201950 | TCEB1 (tGFP-tagged) - Human transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant 1 | 10 ug |
$489.00
|
|
Citations
Elongin C is a mediator of Notch4 activity in human renal tubule cells
Cummins, Mendenhall, Lowry et al
Biochim. Biophys. Acta (2011) 1814 (12), 1748-57 DOI: 10.1016/j.bbapap.2011.09.010
Cummins, Mendenhall, Lowry et al
Biochim. Biophys. Acta (2011) 1814 (12), 1748-57 DOI: 10.1016/j.bbapap.2011.09.010
Cited by 13
AI Summary: OriGene’s Notch4 clone (SC116611) was used to generate constructs for expressing the Notch4 intracellular domain, enabling the study of its interaction with Elongin C in human renal tubule cells.
Snippet: All constructs were ultimately derived from clone SC116611 purchased from Origene (Rockville, MD). ... Our results indicate that the transcriptionally active domain of Notch4 (Notch4 ICD ) is an Elongin C target, implicating the Elongin C complex in the down-regulation of Notch4
Showing 1-1 of 1 papers.
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