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PDE10A (NM_006661) Human Untagged Clone

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SKU
SC115943
PDE10A (untagged)-Human phosphodiesterase 10A (PDE10A), transcript variant 2
  $714.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol PDE10A
Synonyms ADSD2; HSPDE10A; IOLOD; LINC00473; PDE10A19
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene sequence for NM_001130690 edited
ACTCCGCGGCGTCCCCAGGGCGCCAGCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTC
GGCTCCGACATGGAAGATGGACCTTCTAATAATGCGAGCTGCTTCCGAAGGCTGACCGAG
TGCTTCCTGAGCCCCAGTTTGACAGATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCC
CAGGTATTAGATGAATTTGTATCTGAAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTG
AAGAGGAAGAACAACAAATCAGAAGATGAATCAGCTCCTAAGGAAGTCAGCAGGTACCAA
GATACGAATATGCAGGGAGTTGTATATGAACTAAACAGCTATATAGAACAACGGTTGGAC
ACAGGAGGAGACAACCAGCTACTCCTCTATGAACTGAGCAGCATCATTAAAATAGCCACA
AAAGCCGATGGATTTGCACTGTATTTCCTTGGAGAGTGCAATAATAGCCTGTGTATATTC
ACGCCACCTGGGATAAAGGAAGGAAAACCCCGCCTCATCCCTGCTGGGCCCATCACTCAG
GGCACCACCGTCTCTGCTTATGTGGCCAAGTCCAGGAAAACACTGCTAGTAGAAGACATC
CTTGGAGATGAACGATTTCCAAGAGGTACTGGACTGGAATCAGGGACTCGTATCCAGTCT
GTTCTTTGCTTACCAATTGTCACTGCAATTGGTGACTTGATTGGTATTCTCGAGCTGTAT
CGGCACTGGGGCAAAGAAGCCTTCTGTCTTAGTCACCAGGAGGTTGCAACAGCAAATCTT
GCCTGGGCTTCAGTAGCAATACATCAGGTGCAGGTATGCAGAGGCCTTGCCAAACAGACA
GAATTGAATGACTTCCTACTCGACGTATCAAAAACATATTTTGATAACATAGTTGCAATA
GATTCTCTACTTGAACACATAATGATATATGCAAAAAACCTGGTGAATGCCGATCGTTGT
GCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATATTCAGACCTTTTTGATATTGGA
GAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAAGAGATAAGATTTTCAATTGAG
AAAGGAATTGCTGGCCAAGTAGCAAGAACAGGGGAAGTCCTGAACATTCCAGATGCCTAT
GCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACAGGCTACACCACGCGGAACATC
CTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGTGTGGTGCAGATGGTCAACAAA
ATCAGTGGCAGTGCCTTCTCTAAAACAGATGAAAACAACTTCAAAATGTTTGCCGTCTTT
TGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGAATTCGCCACTCAGAGTGCATT
TACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATTTGTACTTCAGAAGAGTGGCAA
GGTCTCATGCAATTCACCCTTCCCGTGCGTCTCTGCAAAGAAATTGAATTATTCCACTTT
GACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTTGTCTACATGGTTCATCGGTCC
TGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGTTTTATTATGTCTGTGAAGAAG
AACTATCGGCGGGTTCCTTATCACAACTGGAAGCATGCGGTCACTGTAGCACACTGCATG
TATGCCATACTTCAGAACAATCACACGCTTTTCACAGACCTTGAGCGCAAAGGACTGCTG
ATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTCAGTAACAGCTACCTGCAGAAG
TTCGACCACCCTCTGGCCGCTCTCTACTCCACTTCCACCATGGAGCAGCACCACTTCTCC
CAGACTGTGTCCATCCTCCAGTTGGAAGGGCACAATATCTTCTCCACTCTGAGCTCCAGT
GAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATCATTGCCACAGACCTTGCTTTA
TACTTTGGAAACAGGAAGCAGTTGGAAGAGATGTACCAGACCGGATCACTAAACCTTAAT
AATCAATCACATAGAGACCGTGTAATTGGTTTGATGATGACTGCCTGTGACCTTTGTTCT
GTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAATGATATATATGCAGAATTCTGG
GCTGAGGGTGATGAAATGAAGAAATTGGGAATACAGCCTATTCCTATGATGGACAGAGAC
AAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTACAATGCCGTGGCCATTCCCTGC
TATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCTCTTCTGAAAGCATGCAGGGAT
AATCTCAGTCAGTGGGAGAAGGTGATTCGAGGGGAGGAGACTGCAACCTGGATTTCATCC
CCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGAGCACTGGTCACCCTGACACGC
TGTCCCACCTACAGATCCTCATCTTGCTTCTTTGACATTCTTTTCCTTTTTTTGGGGGGG
GTGGGGGGAACCTGCACCT
5' Read Nucleotide Sequence
>OriGene 5' read for NM_006661 unedited
NGGGGTTCACATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGCAGCTC
CCTTGAGCGTCCCCACCAGCAGTAGTCACCGCGGCGGCGGTGGCAGCGGCGGCGGGCGGC
GGCGGCTCTTCCTCTCGCCTGCGCTCCAGGGCTTGCTGCTTCCAGCCCGTGCCGGTCCCC
GGCCGCCGCCGCCGCCCCGGCTCCCCCTTGGCCAGGCCGCCCGCCGCGCGGGCTCCCCCG
GCTTCCCCGGCGCCGGCCCAGGCGGCGGCGGCCAAACTCCGCGGCGTCCCCAGGGCGCCA
GCTTCGCCCTCGCCGCCGCGGCCGCGCTGCTCTTCGGCTCCGACATGGAAGATGGACCTT
CTAATAATGCGAGCTGCTTCCGAAGGCTGACCGAGTGCTTCCTGAGCCCCAGTTTGACAG
ATGAAAAAGTGAAGGCATATCTTTCTCTTCACCCCCAGGTATTAGATGAATTTGTATCTG
AAAGTGTTAGTGCAGAGACAGTAGAGAAATGGCTGAAGAGGAAGAACAACAAATCAGAAG
ATGAATCAGCTCCTAAGGAAGTCAGCAGGTACCAAGATACGAATATGCAGGGAGTTGTAT
ATGAACTAAACAGCTATATAGAACAACGGTTGGACACAGGAGGAGACAACCAGCTACTCC
TCTATGAACTGAGCAGCATCATTAAAATAGCCACAAAAGCCGATGGATTTGCACTGTATT
TCCTTGGAGAGTGCAATAATAGCCTGTGTATATTCACGCCACCTGNGATAAAGGAAGGAA
AACCCCGNCTCATCCCTGCTGGGCCCATCACTCAGGGCACCACCGTCTCTGCTTATGTGG
CCAAGTCCAGGAAACACTGCTAGTAGAAGACTCCTTGGAGATGACGATTNCCAAGAGTAC
TGGACTGGATCAC
3' Read Nucleotide Sequence
>OriGene 3' read for NM_006661 unedited
TAATGGACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTATTTTGTTCT
TTATGCAAAGGGTTCAGTAAAACTGCCAANACAACAACAAAAACAATTTTAAAAACTGAC
ATCTTTTGAACTGCTACTTGAAGTTCTGAGATTTATTGTAACATATACCTCATCTCTTCT
CAAAAAGACAGGAAGTCTACTTCGTCTAGTGTTAAATTTATTGATCTCAGCCCTTTAGGT
TGAACTTAAAGAATTATGTTTAGTCTAACTAAATTCATGAAGCTCTGAAATAAGAGTTTG
ACGTTTTGCCATCATTTCTTACTCTGTAACCTCAACGACATTTGTCCTGAGGCTGTGGAC
TACAACTCAAGTTAATTACAAGTAGGTCATACATGAACATTCACCATTCACAATAGTAAT
GTGTAAAAATTCCTATTTATATCCAACAACATCAAAGCAACATTGATGTTAAAGCCCAAG
TACAATACCATAATAGTACCATTTTAAACCCTTATTAGAAAGATACAATGGAAAAGTACC
CCTTCTGGATAATTTTTGTCCATTTCCTTTAAGGCCTCAGCAATATTAGCCTATTAGAAA
AGGCTGGTTTGCAAGTCAAATGGAGTCACTTGGCCAGCTGATTTCTGAACGTGGGGGTGG
TCCTGGTTGCTCAGTGTCTATGATGCCTCACAGAAGAGATTGGCAGGAAGTCCTCTGCTT
GACTTATTTATTTGATGGTACCTTCTTGAAGAGGTTTGCACCCCAGTTACCAGGTGCANG
TTCCCCCCACCCCCCCCAAAAAAAGGAAAAAATGNTCAAAAGCCAGATGAGGATCTCGTA
GTGGGACAGCGTGTCAAGGTGACCAGTGCTCAATCTTCAGATGCAGCTGCCCTCTGAGCC
CCGNATGGGGATGAAAATCCAGTTGCAGGCTCCTCCCTCCAAAAACCTTTTCCCCCTGAC
TGAGATATTACCTGCATGCGTTCAAAAGAGGCCC
Restriction Sites NotI-NotI |
ACCN NM_006661
Insert Size 2600 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_006661.1, NP_006652.1
RefSeq Size 4576 bp
RefSeq ORF 2340 bp
Locus ID 10846
UniProt ID Q9Y233
Cytogenetics 6q27
Domains GAF, PDEase
Protein Families Druggable Genome
Protein Pathways Progesterone-mediated oocyte maturation, Purine metabolism
Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. provided by RefSeq, Dec 2011
Transcript Variant: This variant (2) has an additional exon in the 5' region, which includes an in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) has an alternate and shorter N-terminus, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
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Documents
Resources
"NM_006661" in other vectors (6)
SKU Description Size Price
RC211181 PDE10A (Myc-DDK-tagged)-Human phosphodiesterase 10A (PDE10A), transcript variant 2 10 ug
$713.00
RC211181L1 Lenti ORF clone of Human phosphodiesterase 10A (PDE10A), transcript variant 2, Myc-DDK-tagged 10 ug
$1,013.00
RC211181L2 Lenti ORF clone of Human phosphodiesterase 10A (PDE10A), transcript variant 2, mGFP tagged 10 ug
$1,013.00
RC211181L3 Lenti ORF clone of Human phosphodiesterase 10A (PDE10A), transcript variant 2, Myc-DDK-tagged 10 ug
$1,013.00
RC211181L4 Lenti ORF clone of Human phosphodiesterase 10A (PDE10A), transcript variant 2, mGFP tagged 10 ug
$1,013.00
RG211181 PDE10A (tGFP-tagged) - Human phosphodiesterase 10A (PDE10A), transcript variant 2 10 ug
$789.00 $913.00

file-alt Citations

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity
Li, Lee, Xi et al
Oncogene (2014)
Cited by 74
AI Summary: OriGene’s human full-length PDE10 cDNA and PCMV6-XL4 empty vector were used to transiently transfect colonocyte cell lines, enabling the study of how PDE10 overexpression affects cell proliferation and TCF transcriptional activity in colon tumorigenesis.
Snippet: NCM460 and LT97 cells were transiently transfected with a human full-length PDE10 cDNA (Origene, Rockville, MD, USA) using X-tremeGENE DNA transfection reagent (Roche, Indianapolis, IN, USA) for 72 h. Empty vector PCMV6-XL4 was used as control. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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