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C2 (NM_000063) Human Untagged Clone

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SKU
SC115664
C2 (untagged)-Human complement component 2 (C2), transcript variant 1
  $689.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol C2
Synonyms ARMD14; CO2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC115664 sequence for NM_000063 edited (data generated by NextGen Sequencing)
ATGGGCCCACTGATGGTTCTTTTTTGCCTGCTGTTCCTGTACCCAGGTCTGGCAGACTCG
GCTCCCTCCTGCCCTCAGAACGTGAATATCTCGGGTGGCACCTTCACCCTCAGCCATGGC
TGGGCTCCTGGGAGCCTTCTCACCTACTCCTGCCCCCAGGGCCTGTACCCATCCCCAGCA
TCACGGCTGTGCAAGAGCAGCGGACAGTGGCAGACCCCAGGAGCCACCCGGTCTCTGTCT
AAGGCGGTCTGCAAACCTGTGCGCTGTCCAGCCCCTGTCTCCTTTGAGAATGGCATTTAT
ACCCCACGGCTGGGGTCCTATCCCGTGGGTGGCAATGTGAGCTTCGAGTGTGAGGATGGC
TTCATATTGCGGGGCTCGCCTGTGCGTCAGTGTCGCCCCAACGGCATGTGGGATGGAGAA
ACAGCTGTGTGTGATAATGGGGCTGGCCACTGCCCCAACCCAGGCATTTCACTGGGCGCA
GTGCGGACAGGCTTCCGCTTTGGTCATGGGGACAAGGTCCGCTATCGCTGCTCCTCGAAT
CTTGTGCTCACGGGGTCTTCGGAGCGGGAGTGCCAGGGCAACGGGGTCTGGAGTGGAACG
GAGCCCATCTGCCGCCAACCCTACTCTTATGACTTCCCTGAGGACGTGGCCCCTGCCCTG
GGCACTTCCTTCTCCCACATGCTTGGGGCCACCAATCCCACCCAGAAGACAAAGGAAAGC
CTGGGCCGTAAAATCCAAATCCAGCGCTCTGGTCATCTGAACCTCTACCTGCTCCTGGAC
TGTTCGCAGAGTGTGTCGGAAAATGACTTTCTCATCTTCAAGGAGAGCGCCTCCCTCATG
GTGGACAGGATCTTCAGCTTTGAGATCAATGTGAGCGTTGCCATTATCACCTTTGCCTCA
GAGCCCAAAGTCCTCATGTCTGTCCTGAACGACAACTCCCGGGATATGACTGAGGTGATC
AGCAGCCTGGAAAATGCCAACTATAAAGATCATGAAAATGGAACTGGGACTAACACCTAT
GCGGCCTTAAACAGTGTCTATCTCATGATGAACAACCAAATGCGACTCCTCGGCATGGAA
ACGATGGCCTGGCAGGAAATCCGACATGCCATCATCCTTCTGACAGATGGAAAGTCCAAT
ATGGGTGGCTCTCCCAAGACAGCTGTTGACCATATCAGAGAGATCCTGAACATCAACCAG
AAGAGGAATGACTATCTGGACATCTATGCCATCGGGGTGGGCAAGCTGGATGTGGACTGG
AGAGAACTGAATGAGCTAGGGTCCAAGAAGGATGGTGAGAGGCATGCCTTCATTCTGCAG
GACACAAAGGCTCTGCACCAGGTCTTTGAACATATGCTGGATGTCTCCAAGCTCACAGAC
ACCATCTGCGGGGTGGGGAACATGTCAGCAAACGCCTCTGACCAGGAGAGGACACCCTGG
CATGTCACTATTAAGCCCAAGAGCCAAGAGACCTGCCGGGGGGCCCTCATCTCCGACCAA
TGGGTCCTGACAGCAGCTCATTGCTTCCGCGATGGCAACGACCACTCCCTGTGGAGGGTC
AATGTGGGAGACCCCAAATCCCAGTGGGGCAAAGAATTCCTTATTGAGAAGGCGGTGATC
TCCCCAGGGTTTGATGTCTTTGCCAAAAAGAACCAGGGAATCCTGGAGTTCTATGGTGAT
GACATAGCTCTGCTGAAGCTGGCCCAGAAAGTAAAGATGTCCACCCATGCCAGGCCCATC
TGCCTTCCCTGCACGATGGAGGCCAATCTGGCTCTGCGGAGACCTCAAGGCAGCACCTGT
AGGGACCATGAGAATGAACTGCTGAACAAACAGAGTGTTCCTGCTCATTTTGTCGCCTTG
AATGGGAGCAAACTGAACATTAACCTTAAGATGGGAGTGGAGTGGACAAGCTGTGCCGAG
GTTGTCTCCCAAGAAAAAACCATGTTCCCCAACTTGACAGATGTCAGGGAGGTGGTGACA
GACCAGTTCCTATGCAGTGGGACCCAGGAGGATGAGAGTCCCTGCAAGGGAGAATCTGGG
GGAGCAGTTTTCCTTGAGCGGAGATTCAGGTTTTTTCAGGTGGGTCTGGTGAGCTGGGGT
CTTTACAACCCCTGCCTTGGCTCTGCTGACAAAAACTCCCGCAAAAGGGCCCCTCGTAGC
AAGGTCCCGCCGCCACGAGACTTTCACATCAATCTCTTCCGCATGCAGCCCTGGCTGAGG
CAGCACCTGGGGGATGTCCTGAATTTTTTACCCCTCTAG

Clone variation with respect to NM_000063.4
5' Read Nucleotide Sequence
>OriGene 5' read for NM_000063 unedited
NGTTCGAATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGCTAACANAAG
ACCATCCCCCTTGCCACTCCCTGGTTTTTCTTCTCTGGCAGCAATGAAGCAGCTGCTGAC
CCAGCTCTAGTTTTCGGGAAGTCAGATGACCTTTTCCCTCCCGCGGCTCTCTACCTCTCG
CCGCCCCTAGGGAGGACACCATGGGCCCACTGATGGTTCTTTTTTGCCTGCTGTTCCTGT
ACCCAGGTCTGGCAGACTCGGCTCCCTCCTGCCCTCAGAACGTGAATATCTCGGGTGGCA
CCTTCACCCTCAGCCATGGCTGGGCTCCTGGGAGCCTTCTCACCTACTCCTGCCCCCAGG
GCCTGTACCCATCCCCAGCATCACGGCTGTGCAAGAGCAGCGGACAGTGGCAGACCCCAG
GAGCCACCCGGTCTCTGTCTAAGGCGGTCTGCAAACCTGTGCGCTGTCCAGCCCCTGTCT
CCTTTGAGAATGGCATTTATACCCCACGGCTGGGGTCCTATCCCGTGGGTGGCAATGTGA
GCTTCGAGTGTGAGGATGGCTTCATATTGCGGGGCTCGCCTGTGCGTCAGTGTCGCCCCA
ACGGCATGTGGGATGGAGAAACAGCTGTGTGTGATAATGGGGCTGGCCACTGCCCCAACC
CAGGCATTTCACTGGGCGCAGTGCGGACAGGCTTCCGCTNTGGTCATGGGGACAAGGTCC
GCTATCGCTGCTCCTCGAATCTTGTGCTCACGGNGTCTTCGGAGCGGNAGTGCCAGGGCA
ACGGGGTCTGGAGTGGAACGGAGCCCATCTGCCGNCAACCCTACTCTTATGACTTNCCTG
NAGGACGTGGGCCCTGNCCTGGGCACTTNCTTCTCCCACATGCTGGNNGCCACCATCCCA
CCCAAAGACAAAGGAAAGCT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_000063 unedited
CCCCCATTCCTTGCCCGCGGCCGCAATCTACAGTCGACTTTTTTTTTTTTTTTTTTTGTG
GAAACCATTGATTTTTATTAATTTCATAACTGGGAAATTCCATGTGAAAGTGAAACAAGC
ATGAGTCAAGTCAACCAGGGAAGGAATCTGGGGACAGGCCACGGAGCGGGAGGTGGGGCA
GCGAGGCAGTCCTGCTGGTAGGAGCCCTGAGGATTTCCCAGCTTGTGTGCGCTGCCTCTG
GCATCCTAGAGACCCGGATTTACTCAGCTAGGAGAGAGGATGGATCACAGGGTCTAAGGG
TGGCCATTCAGAGGTAGAAGATGGAGGGGCGGCAGATTCTGGCAGGGCAGCAGAGGGCTC
AGTGGCCATGGCTAGAGGGGTAAAAAATTCAGGACATCCCCCAGGTGCTGCCTCAGCCAG
GGCTGCATGCGGAAGAGATTGATGTGAAAGTCTCGTGGCGGCGGGACCTTGCTACGAGGG
GCCCTTTTGCGGGAGTTTTTGTCAGCAGAGCCCAGGCAGGGGTTGTAAAGACCCCAGCTC
ACCAGACCCACCTGACAAAACCTGAATCTCCGATCAAGGAAAACTGCTCCCCCAGATTCT
CCCTTGCAGGGACTCTCATCCTCCTGGGTCCCACTGCATAGGAACTGGCCCGCCACCACC
TCCCTGACATCTGTCAAGCTGGGCGAACACGGCCTCTTTTTTTTCTAGACTCCCTCGGCC
CAAGCTTCGTCACCATCCTTCCCCTCCTCAGGGCCCCGCCTACACCTTGTCCCAATTCCG
CCCCCTCCCCTCCATCCCTACATCTCTTCCCTCACACACCCCCTTCATCCCCCACCCCTC
CTCCCCCCCTCTCCCCGCTCATCACTGCCCCTTCCCCTGTCGCCGCTCTCTCCCCCCCCC
CTCCGCCGCCCCCACCCCCG
Restriction Sites NotI-NotI |
ACCN NM_000063
Insert Size 2740 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_000063.3, NP_000054.2
RefSeq Size 2609 bp
RefSeq ORF 2259 bp
Locus ID 717
UniProt ID P06681
Cytogenetics 6p21.33
Domains CCP, Tryp_SPc, VWA
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades, Systemic lupus erythematosus
Summary Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.provided by RefSeq, Mar 2009
Transcript Variant: This variant (1) encodes the longest isoform (1).
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Documents
Resources
"NM_000063" in other vectors (6)
SKU Description Size Price
RC208097 C2 (Myc-DDK-tagged)-Human complement component 2 (C2), transcript variant 1 10 ug
$689.00
RC208097L1 Lenti ORF clone of Human complement component 2 (C2), transcript variant 1, Myc-DDK-tagged 10 ug
$989.00
RC208097L2 Lenti ORF clone of Human complement component 2 (C2), transcript variant 1, mGFP tagged 10 ug
$989.00
RC208097L3 Lenti ORF clone of Human complement component 2 (C2), transcript variant 1, Myc-DDK-tagged 10 ug
$989.00
RC208097L4 Lenti ORF clone of Human complement component 2 (C2), transcript variant 1, mGFP tagged 10 ug
$989.00
RG208097 C2 (tGFP-tagged) - Human complement component 2 (C2), transcript variant 1 10 ug
$789.00 $889.00

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