SERPING1 (NM_000062) Human Untagged Clone

SKU SC115553

SERPING1 (untagged)-Human serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (SERPING1), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: SERPING1
• Synonyms: C1IN; C1INH; C1NH; HAE1; HAE2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_000062, the custom clone sequence may differ by one or more nucleotides; ; ; ATGGCCTCCAGGCTGACCCTGCTGACCCTCCTGCTGCTGCTGCTGGCTGGGGATAGAGCCTCCTCAAATC; CAAATGCTACCAGCTCCAGCTCCCAGGATCCAGAGAGTTTGCAAGACAGAGGCGAAGGGAAGGTCGCAAC; AACAGTTATCTCCAAGATGCTATTCGTTGAACCCATCCTGGAGGTTTCCAGCTTGCCGACAACCAACTCA; ACAACCAATTCAGCCACCAAAATAACAGCTAATACCACTGATGAACCCACCACACAACCCACCACAGAGC; CCACCACCCAACCCACCATCCAACCCACCCAACCAACTACCCAGCTCCCAACAGATTCTCCTACCCAGCC; CACTACTGGGTCCTTCTGCCCAGGACCTGTTACTCTCTGCTCTGACTTGGAGAGTCATTCAACAGAGGCC; GTGTTGGGGGATGCTTTGGTAGATTTCTCCCTGAAGCTCTACCACGCCTTCTCAGCAATGAAGAAGGTGG; AGACCAACATGGCCTTTTCCCCATTCAGCATCGCCAGCCTCCTTACCCAGGTCCTGCTCGGGGCTGGGGA; GAACACCAAAACAAACCTGGAGAGCATCCTCTCTTACCCCAAGGACTTCACCTGTGTCCACCAGGCCCTG; AAGGGCTTCACGACCAAAGGTGTCACCTCAGTCTCTCAGATCTTCCACAGCCCAGACCTGGCCATAAGGG; ACACCTTTGTGAATGCCTCTCGGACCCTGTACAGCAGCAGCCCCAGAGTCCTAAGCAACAACAGTGACGC; CAACTTGGAGCTCATCAACACCTGGGTGGCCAAGAACACCAACAACAAGATCAGCCGGCTGCTAGACAGT; CTGCCCTCCGATACCCGCCTTGTCCTCCTCAATGCTATCTACCTGAGTGCCAAGTGGAAGACAACATTTG; ATCCCAAGAAAACCAGAATGGAACCCTTTCACTTCAAAAACTCAGTTATAAAAGTGCCCATGATGAATAG; CAAGAAGTACCCTGTGGCCCATTTCATTGACCAAACTTTGAAAGCCAAGGTGGGGCAGCTGCAGCTCTCC; CACAATCTGAGTTTGGTGATCCTGGTACCCCAGAACCTGAAACATCGTCTTGAAGACATGGAACAGGCTC; TCAGCCCTTCTGTTTTCAAGGCCATCATGGAGAAACTGGAGATGTCCAAGTTCCAGCCCACTCTCCTAAC; ACTACCCCGCATCAAAGTGACGACCAGCCAGGATATGCTCTCAATCATGGAGAAATTGGAATTCTTCGAT; TTTTCTTATGACCTTAACCTGTGTGGGCTGACAGAGGACCCAGATCTTCAGGTTTCTGCGATGCAGCACC; AGACAGTGCTGGAACTGACAGAGACTGGGGTGGAGGCGGCTGCAGCCTCCGCCATCTCTGTGGCCCGCAC; CCTGCTGGTCTTTGAAGTGCAGCAGCCCTTCCTCTTCGTGCTCTGGGACCAGCAGCACAAGTTCCCTGTC; TTCATGGGGCGAGTATATGACCCCAGGGCCTGA; ;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000062 unedited; TTCAGATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGGGGAGTCCGCTG; ACGTCGCCGCCCAGATGGCCTCCAGGCTGACCCTGCTGACCCTCCTGCTGCTGCTGCTGG; CTGGGGATAGAGCCTCCTCAAATCCAAATGCTACCAGCTCCAGCTCCCAGGATCCAGAGA; GTTTGCAAGACAGAGGCGAAGGGAAGGTCGCAACAACAGTTATCTCCAAGATGCTATTCG; TTGAACCCATCCTGGAGGTTTCCAGCTTGCCGACAACCAACTCAACAACCAATTCAGCCA; CCAAAATAACAGCTAATACCACTGATGAACCCACCACACAACCCACCACAGAGCCCACCA; CCCAACCCACCATCCAACCCACCCAACCAACTACCCAGCTCCCAACAGATTCTCCTACCC; AGCCCACTACTGGGTCCTTCTGCCCAGGACCTGTTACTCTCTGCTCTGACTTGGAGAGTC; ATTCAACAGAGGCCGTGTTGGGGGATGCTTTGGTAGATTTCTCCCTGAAGCTCTACCACG; CCTTCTCAGCAATGAAGAAGGTGGAGACCAACATGGCCTTTTCCCCATTCAGCATCGCCA; GCCTCCTTACCCAGGTCCTGCTCGGGGCTGGGGAGAACACCAAAACAAACTTGGAGAGCA; TCCTCTCTTACCCCAAGGACTTCACCTGTGTCCACCAGGCCCTGAAGGGCTTCACGACCA; AAGGTGTCACCTCAGTCTCTCAGATCTTCCACAGCCCAGACCTGGCCATAAGGGACACCT; TTGTGAATGCCTCTCGGACCCTGTACAGCAGCAGCCCCAGAGTCCTAAAGCACAACAGTG; ACGCCAACTTGGAGCTCATCACACCTGGGTGGCNCNNAGACACCACNNACAGATCAGCCG; GCTGCTAGACAGTCTGCCCTTCGATACCGNCTTGTNCTNCTCATGCTATCTACTGAGTGC; CAGTGGAAGACACATA;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000062 unedited; GACCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGGTCTGTCAGGTTTT; ATTTATAGAGTCTGGTGAACTTGAACTAGAGAAAGCTGCAAAAAGTGGTTTGGAGAGCAT; GGCAGGGCCATGGAGAAGGGCTAATAGAAGCAGGTCCCTTGCCCAGACCCTCAGGGAGCC; CTTTTGGTGGATAGCGGACACCTGAGGCAGGAGGTGGCAGGGGCCAAGTCCAGGCAGGCA; GCAGCAGGGCTGCAACTGAGAGCTGAGGCTGGAGAGGTAGCGCTCGCCCTAACCTGATCC; TGCAGGTCTCAGGCCCTGGGGTCATATACTCGCCCCATGAAGACAGGGAACTTGTGCTGC; TGGTCCCAGAGCACGAAGAGGAAGGGCTGCTGCACTTCAAAGACCAGCAGGGTGCGGGCC; ACAGAGATGGCGGAGGCTGCAGCCGCCTCCACCCCAGTCTCTGTCAGTTCCAGCACTGTC; TGGTGCTGCATCGCAGAAACCTGAAGATCTGGGTCCTCTGTCAGCCCACCCAGGTTAAGG; TCATAAGACCACTCGAAGAATTCCAATCTCTCCATGATTGAGACGATAACCTCGCTTGGT; CCTCACTCTGATGCCGGGCAGTGTTAGGATAGTGCGCCTGCACCTTGCACATTTCCACTT; TCCCCCTGATCGGCCTCGAAAACGAAGGGCTCAAAGCCCGTCTCCTGCCTCCCACAACAT; GCTTTACGTCCCGTGGTACCCGGACTACTAACCCCTATTGCCGCCAACCCCCCTGTCCCC; CCTCCCTTCCAAATCCGCCCCACCACGCCCTCCGACCCTCACGTCTTCTTCCCCGCCTCC; CACACCCCCCCTTCACCGACGCCTCCCCCCCCCTCCTCCCACATCGCCCACCCCCCTGCA; CTCCTCCCCTCCCCCCGCC;
• Restriction Sites: NotI-NotI
• ACCN: NM_000062
• Insert Size: 1820 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000062.2, NP_000053.2
• RefSeq Size: 1984 bp
• RefSeq ORF: 1503 bp
• Locus ID: 710
• UniProt ID: P05155
• Cytogenetics: 11q12.1
• Domains: SERPIN
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades
• Summary: This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its encoded protein, C1 inhibitor, inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. It is synthesized in the liver, and its deficiency is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, May 2020]; Transcript Variant: This variant (1) represents the longer transcript.