DCDC2 (NM_016356) Human Untagged Clone
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | DCDC2 |
| Synonyms | DCDC2A; DFNB66; NPHP19; NSC; RU2; RU2S |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_016356 |
| Insert Size | 2440 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_016356.1, NP_057440.1 |
| RefSeq Size | 2167 bp |
| RefSeq ORF | 1431 bp |
| Locus ID | 51473 |
| UniProt ID | Q9UHG0 |
| Cytogenetics | 6p22.3 |
| Domains | DCX |
| Summary | This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. provided by RefSeq, Jan 2013 Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_016356" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC208721 | DCDC2 (Myc-DDK-tagged)-Human doublecortin domain containing 2 (DCDC2), transcript variant 1 | 10 ug |
$457.00
|
|
| RC208721L1 | Lenti ORF clone of Human doublecortin domain containing 2 (DCDC2), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC208721L2 | Lenti ORF clone of Human doublecortin domain containing 2 (DCDC2), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RC208721L3 | Lenti ORF clone of Human doublecortin domain containing 2 (DCDC2), transcript variant 1, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC208721L4 | Lenti ORF clone of Human doublecortin domain containing 2 (DCDC2), transcript variant 1, mGFP tagged | 10 ug |
$757.00
|
|
| RG208721 | DCDC2 (tGFP-tagged) - Human doublecortin domain containing 2 (DCDC2), transcript variant 1 | 10 ug |
$489.00
$657.00
|
|
Citations
DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling
Schueler, Braun, Chandrasekar et al
Am J Hum Genet (2015) 96 (1), 81-92 DOI: 10.1016/j.ajhg.2014.12.002
Schueler, Braun, Chandrasekar et al
Am J Hum Genet (2015) 96 (1), 81-92 DOI: 10.1016/j.ajhg.2014.12.002
Cited by 123
AI Summary: In this study, OriGene's DCDC2 Myc-DDK tagged cDNA clone was used to express wild-type and mutant forms of DCDC2 in cell-based rescue experiments, enabling the authors to demonstrate that only wild-type DCDC2 could restore ciliogenesis and inhibit Wnt signaling, thus highlighting the pathogenic mechanism of DCDC2 mutations in renal-hepatic ciliopathy.
Showing 1-1 of 1 papers.
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