GTF2IRD1 (NM_016328) Human Untagged Clone
SKU
SC114317
GTF2IRD1 (untagged)-Human GTF2I repeat domain containing 1 (GTF2IRD1), transcript variant 1
$1,318.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | GTF2IRD1 |
| Synonyms | BEN; CREAM1; GTF3; hMusTRD1alpha1; MUSTRD1; RBAP2; WBS; WBSCR11; WBSCR12 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_016328 |
| Insert Size | 3160 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_016328.1, NP_057412.1 |
| RefSeq Size | 3446 bp |
| RefSeq ORF | 2880 bp |
| Locus ID | 9569 |
| UniProt ID | Q9UHL9 |
| Cytogenetics | 7q11.23 |
| Domains | GTF2I |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Basal transcription factors |
| Summary | The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. provided by RefSeq, Nov 2010 Transcript Variant: This variant (1) uses alternate splice sites in the coding region, compared to variant 3. The encoded isoform (1) is shorter compared to isoform 3. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_016328" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC202128 | GTF2IRD1 (Myc-DDK-tagged)-Human GTF2I repeat domain containing 1 (GTF2IRD1), transcript variant 1 | 10 ug |
$1,317.00
|
|
| RC202128L1 | Lenti ORF clone of Human GTF2I repeat domain containing 1 (GTF2IRD1), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,617.00
|
|
| RC202128L2 | Lenti ORF clone of Human GTF2I repeat domain containing 1 (GTF2IRD1), transcript variant 1, mGFP tagged | 10 ug |
$1,617.00
|
|
| RC202128L3 | Lenti ORF clone of Human GTF2I repeat domain containing 1 (GTF2IRD1), transcript variant 1, Myc-DDK-tagged | 10 ug |
$1,617.00
|
|
| RC202128L4 | Lenti ORF clone of Human GTF2I repeat domain containing 1 (GTF2IRD1), transcript variant 1, mGFP tagged | 10 ug |
$1,617.00
|
|
| RG202128 | GTF2IRD1 (tGFP-tagged) - Human GTF2I repeat domain containing 1 (GTF2IRD1), transcript variant 1 | 10 ug |
$1,517.00
|
|
| SC322443 | GTF2IRD1 (untagged)-Human GTF2I repeat domain containing 1 (GTF2IRD1), transcript variant 1 | 10 ug |
$1,318.00
|
|
Citations
The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina
Reichman, Kalathur, Lambard et al
Hum Mol Genet (2010) 19 (2), 250-61 DOI: 10.1093/hmg/ddp484
Reichman, Kalathur, Lambard et al
Hum Mol Genet (2010) 19 (2), 250-61 DOI: 10.1093/hmg/ddp484
Cited by 48
AI Summary: In this study, OriGene products—including the human CHX10/VSX2 Myc-DDK-tagged ORF cDNA clone and the mouse Nxnl1 cDNA clone—were used to investigate how specific transcription factors regulate the Nxnl1 (RdCVF) promoter, helping to identify CHX10/VSX2 as a key regulator of RdCVF expression in the inner retina.
Showing 1-1 of 1 papers.
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