CLN6 (NM_017882) Human Untagged Clone

SKU SC113923

CLN6 (untagged)-Human ceroid-lipofuscinosis, neuronal 6, late infantile, variant (CLN6)

Product Data

• Type: Human Untagged Clone
• Target Symbol: CLN6
• Synonyms: CLN4A; HsT18960; nclf
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_017882 edited; GAATTCGGCACGAGGGGGCAGCCGAGCTGAACCGGTCTCTTCCTCGGAAAGGCAGGGCCG; AGGGGCCTGCGGGGCAGCCATGGAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGG; CGGCCCAGGCGCGCAGCTGGGCGCCTCCTTCCTGCAGGCCAGGCATGGCTCTGTGAGCGC; TGATGAGGCTGCCCGCACGGCTCCCTTCCACCTCGACCTCTGGTTCTACTTCACACTGCA; GAACTGGGTTCTGGACTTTGGGCGTCCCATTGCCATGCTGGTATTCCCTCTCGAGTGGTT; TCCACTCAACAAGCCCAGTGTTGGGGACTACTTCCACATGGCCTACAACGTCATCACGCC; CTTTCTCTTGCTCAAGCTCATCGAGCGGTCCCCCCGCACCCTGCCACGCTCCATCACGTA; CGTGAGCATCATCATCTTCATCATGGGTGCCAGCATCCACCTGGTGGGTGACTCTGTCAA; CCACCGCCTGCTCTTCAGTGGCTACCAGCACCACCTGTCTGTCCGTGAGAACCCCATCAT; CAAGAATCTCAAGCCGGAGACGCTGATCGACTCCTTTGAGCTGCTCTACTATTATGATGA; GTACCTGGGTCACTGCATGTGGTACATCCCCTTCTTCCTCATCCTCTTCATGTACTTCAG; CGGCTGCTTTACTGCCTCTAAAGCTGAGAGCTTGATTCCAGGGCCTGCCCTGCTCCTGGT; GGCACCCAGTGGCCTGTACTACTGGTACCTGGTCACCGAGGGCCAGATCTTCATCCTCTT; CATCTTCACCTTCTTCGCCATGCTGGCCCTCGTCCTGCACCAGAAGCGCAAGCGCCTCTT; CCTGGACAGCAACGGCCTCTTCCTCTTCTCCTCCTTCGCACTGACCCTCTTGCTTGTGGC; GCTCTGGGTCGCCTGGCTGTGGAATGACCCTGTTCTCAGGAAGAAGTACCCGGGTGTCAT; CTACGTCCCTGAGCCCTGGGCTTTCTACACCCTTCACGTCAGCAGTCGGCACTGAGTCCC; TGGCACCAGGCTCTGGCGCTCTGCTGGGTGGGAGGGTGGGCCATGGAGGGCATCTGAATA; CAGGAGTAGGGGGGGTGTGGGTGTGTAACCAGAGACCGAGAGCATGAGTGGGGTGTGCCT; CGTGTGCGTGGATTCGTGTGTGTGTGTGTGTCTTGTATATGTGTGCGCAGAGTGCATCAT; TTTCAGACTCTACTATTTCCGTCAAGTTTCTGTTTGATTTGGATCATCTCAGGATCGGAT; TCTGTTTTAGAGTGTTTCTGGGCCAGGATCCGGGCCCCTGCCCTCCTCTGCACCTGACCA; CACTCCCTACTCAGGGCTAGTCTGTTCTTCCCGGACATCTTCTGGTAGCCGTGCAGGAGA; GGGCTGGGTGGGGCAGAGGCCAGGAGGGGACCTGGTGTGTCACCTGCCCACCACCTGGCT; CATCCCTCAGGCCCACCCTGACCCTACATTACATAGGTTACGTCAGCCTACTGTGGCTGT; TGAGCAAAGCATTTCTCCTTTCTGGGCCTCATTTGCACTAGATGGGCCTGTGGTCCAAAG; TAGGTCAGTAGGTTGGGGTTGCTGACACCCCTTGGGTGCAGCTTTGGGACAGATGAGTGG; CTCTGTCCTGTCACTGCCCTCTCCCTGCCTGGGGGCTATGTGCACTCCAGACCCCTGCCC; AGGCTCAGGCCCATGAGGTATGGAGACACCCTGGCCCCCAGGAGCTGGAGGCACCGCCCA; CTCCCCTGGCATTCCAGCTTTGCAGGTGACCCTCCTCTACCCAAAGCTCTGTCCCCCTGC; TCCCACTCCAGAAGAACTGCGGCACGTGCTTCGGGCAGCCTAGCCACAGGCTTTGAGCGC; CTGCATTCCTGGGGGCTGGAGGGTGGGGTGCCAAAGGCCCTGAGCAAAAGCCAGAGCTCC; TCTCATCAAAGCCTTTACAAGGTGCTGGGCCCAGAGGCTTTGCCTTGACAGAGTGGCCCA; GGGTTTCAAGGGAGGAGGAACCTCCCCCTACCTAGGACCCTTCCTGTGGGGGGTCTACAG; AGTCAGGGACAGAAGGGAAGGGACCCACAGGAAGTCACAGTGGTGCCCAGGGATGTGTCA; GCCCCCAGCCACGGGGACGCGGGATTCAAGAATGAAGTAAATACAGTCACAGCCCCAAAA; AAAAAAAAAAAAAACTCGAC;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_017882 unedited; GGGTGTTTAGATTTGTATACGACTCACTATAGGCGGCCGCGAATCGGCACGAGGGGGCAG; CCGAGCTGAACCGGTCTCTTCCTCGGAAGGCAGGGCCGAGGGGCCTGCGGGGCAGCCATG; GAGGCGACGCGGAGGCGGCAGCACCTGGGAGCGACGGGCGGCCCAGGCGCGCAGCTGGGC; GCCTCCTTCCTGCAGGCCAGGCATGGCTCTGTGAGCGCTGATGAGGCTGCCCGCACGGCT; CCCTTCCACCTCGACCTCTGGTTCTACTTCACACTGCAGAACTGGGTTCTGGACTTTGGG; CGTCCCATTGCCATGCTGGTATTCCCTCTCGAGTGGTTTCCACTCAACAAGCCCAGTGTT; GGGGACTACTTCCACATGGCCTACAACGTCATCACGCCCTTTCTCTTGCTCAAGCTCATC; GAGCGGTCCCCCCGCACCCTGCCACGCTCCATCACGTACGTGAGCATCATCATCTTCATC; ATGGGTGCCAGCATCCACCTGGTGGGTGACTCTGTCAACCACCGCCTGCTCTTCAGTGGC; TACCAGCACCACCTGTCTGTCCGTGAGAACCCCATCATCAAGAATCTCAAGCCGGAGACG; CTGATCGACTCCTTTGAGCTGCTCTACTATTATGATGAGTACCTGGGTCACTGCATGTGG; TACATCCCCTTCTTCCTCATCCTCTTCATGTACTTCAGCGGCTGCTTTACTGCCTCTAAA; GCTGAGAGCTTGATTCCAGGGCCTGCCCTGCTCCTGGTGGCACCCAGTGGCCTGTACTAC; TGGTACCTGGTCACCGNAGGCCAGATCTTCATCCTCTTCATCTTCACCTTCTTCGCCATG; CTGGCCCTCGTCCTGCACCAAAAGCGCAAGCGCCTCTTCCTG;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_017882 unedited; GTACCAAAGCGGCNCTCNAGGTNCGAGAAAAAATCTTTTTTTTTTGGGGCTGTGACTGTT; TTTACTTCATTCTTGAATCCCGCGTCCCCGTGGCTGGGGGCTGACACATCCCTGGGCACC; ACTGTGACTTCCTGTGGGTCCCTTCCCTTCTGTCCCTGACTCTGTAGACCCCCCACAGGA; AGGGTCCTAGGTAGGGGGAGGGTCCTTCTCCTCNTAAACCCTGGGCCACTCTGTCAAGGC; AAAGCCTCTGGGCCCAGCACCTTGTAAAGGCTTTGATGAGAGGAGCTCTGGCTTTTGCTC; AGGGCCTTTGGCACCCCACCCTCCAGCCCCCAGGAATGCAGGCGCTCAAAGCCTGTGGCT; AGGCTGCCCGAAGCACGTGCCGCAGTTCTTCTGGAGTGGGAGCAGGGGGACAGAGCTTTG; GGTAGAGGAGGGTCACCTGCAAAGCTGGAATGCCAGGGGAGTGGGCGGTGCCTCCAGCTC; CTGGGGGCCAGGGTGTCTCCATACCTCATGGGCCTGAGCCTGGGCAGGGGTCTGGAGTGC; ACATAGCCCCCAGGCAGGGAGAGGGCAGTGACAGGACAGAGCCACTCATCTGTCCCAAAG; CTGCACCCAAGGGGTGTCAGCAACCCCAACCTACTGACCTACTTTGGACCACAGGCCCAT; CTAGTGCAAATGAGGCCCCAGAAGGAGAAATGCTCTGCTCAACAGCCACAGTAGGCTGAC; GTAACCTATGTAATGTATGGTCAAGGTGGGCCCTGAAGGATGAGCCACGTGGTGGGCAGG; TGACACACCAGGTCCCCCTCCTGGGCCTTTGGCCCACCCAGCCCTCTCCTGCACGGTTAC; CANAAGATGTCCCGGGAAGACAGACTACCCCTGAGTTAGGAGTGTGGGCCAAGTGCACAA; GAGGGCCAGGGCCCCCGATCCTGCCCACAACACTCTTAAAN;
• Restriction Sites: NotI-NotI
• ACCN: NM_017882
• Insert Size: 2350 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_017882.1, NP_060352.1
• RefSeq Size: 2227 bp
• RefSeq ORF: 936 bp
• Locus ID: 54982
• UniProt ID: Q9NWW5
• Cytogenetics: 15q23
• Protein Families: Transmembrane
• Summary: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function. [provided by RefSeq, Oct 2008]