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HDAC3 (NM_003883) Human Untagged Clone

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SKU
SC112704
HDAC3 (untagged)-Human histone deacetylase 3 (HDAC3)
  $457.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol HDAC3
Synonyms HD3; KDAC3; RPD3; RPD3-2
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC112704 sequence for NM_003883 edited (data generated by NextGen Sequencing)
ATGGCCAAGACCGTGGCCTATTTCTACGACCCCGACGTGGGCAACTTCCACTACGGAGCT
GGACACCCTATGAAGCCCCATCGCCTGGCATTGACCCATAGCCTGGTCCTGCATTACGGT
CTCTATAAGAAGATGATCGTCTTCAAGCCATACCAGGCCTCCCAGCATGACATGTGCCGC
TTCCACTCCGAGGACTACATTGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAAGGC
TTCACCAAGAGTCTTAATGCCTTCAACGTAGGCGATGACTGCCCAGTGTTTCCCGGGCTC
TTTGAGTTCTGCTCGCGTTACACAGGCGCATCTCTGCAAGGAGCAACCCAGCTGAACAAC
AAGATCTGTGATATTGCCATTAACTGGGCTGGTGGTCTGCACCATGCCAAGAAGTTTGAG
GCCTCTGGCTTCTGCTATGTCAACGACATTGTGATTGGCATCCTGGAGCTGCTCAAGTAC
CACCCTCGGGTGCTCTACATTGACATTGACATCCACCATGGTGACGGGGTTCAAGAAGCT
TTCTACCTCACTGACCGGGTCATGACGGTGTCCTTCCACAAATACGGAAATTACTTCTTC
CCTGGCACAGGTGACATGTATGAAGTCGGGGCAGAGAGTGGCCGCTACTACTGTCTGAAC
GTGCCCCTGCGGGATGGCATTGATGACCAGAGTTACAAGCACCTTTTCCAGCCGGTTATC
AACCAGGTAGTGGACTTCTACCAACCCACGTGCATTGTGCTCCAGTGTGGAGCTGACTCT
CTGGGCTGTGATCGATTGGGCTGCTTTAACCTCAGCATCCGAGGGCATGGGGAATGCGTT
GAATATGTCAAGAGCTTCAATATCCCTCTACTCGTGCTGGGTGGTGGTGGTTATACTGTC
CGAAATGTTGCCCGCTGCTGGACATATGAGACATCGCTGCTGGTAGAAGAGGCCATTAGT
GAGGAGCTTCCCTATAGTGAATACTTCGAGTACTTTGCCCCAGACTTCACACTTCATCCA
GATGTCAGCACCCGCATCGAGAATCAGAACTCACGCCAGTATCTGGACCAGATCCGCCAG
ACAATCTTTGAAAACCTGAAGATGCTGAACCATGCACCTAGTGTCCAGATTCATGACGTG
CCTGCAGACCTCCTGACCTATGACAGGACTGATGAGGCTGATGCAGAGGAGAGGGGTCCT
GAGGAGAACTATAGCAGGCCAGAGGCACCCAATGAGTTCTATGATGGAGACCATGACAAT
GACAAGGAAAGCGATGTGGAGATTTAA

Clone variation with respect to NM_003883.3
165 a=>g
5' Read Nucleotide Sequence
>OriGene 5' read for NM_003883 unedited
NNNCCTGTCANAAATTGTATACGACTCCTATAGGCGGCCCGCGAATTCGCACCAGGCCGC
GGGCGGCGGGCGGCGGAGGTGCGGGGCCTGCTCCCGCCGGCACCATGGCCAAGACCGTGG
CCTATTTCTACGACCCCGACGTGGGCAACTTCCACTACGGAGCTGGACACCCTATGAAGC
CCCATCGCCTGGCATTGACCCATAGCCTGGTCCTGCATTACGGTCTCTATAAGAAGATGA
TCGTCTTCAAGCCATACCAGGCCTCCCAGCATGACATGTGCCGCTTCCACTCCGAGGACT
ACATTGACTTCCTGCAGAGAGTCAGCCCCACCAATATGCAAGGCTTCACCAAGAGTCTTA
ATGCCTTCAACGTAGGCGATGACTGCCCAGTGTTTCCCGGGCTCTTTGAGTTCTGCTCGC
GTTACACAGGCGCATCTCTGCAAGGAGCAACCCAGCTGAACAACAAGATCTGTGATATTG
CCATTAACTGGGCTGGTGGTCTGCACCATGCCAAGAAGTTTGAGGCCTCTGGCTTCTGCT
ATGTCAACGACATTGTGATTGGCATCCTGGAGCTGCTCAAGTACCACCCTCGGGTGCTCT
ACATTGACATTGACATCCACCATGGTGACGGNGTTCAAGAAGCTTTCTACCTCACTGACC
GNGTCATGACGGTGTCCTTCCACAAATACGGAAATTACTTCTTCCCTGGCACAGGTGACA
TGTATGAAGTCGGNGCAGAGAGTGGCCGCTACTACTGTCTGAACGTGCCCCTGCGGNATG
GCATTGATGACCAGAGNTACAAGCACCTTTTCCAGCCGGNTATCAACCAGNTAGTGGACT
TCTACCAACCCACGTGCATTGTGCTTCAGTGTGGAGCTGACTCTCTGGCCTC
3' Read Nucleotide Sequence
>OriGene 3' read for NM_003883 unedited
CCAAAAGTGAGTTTCAGACATTTTCATATCCTCCCCACACTTGAAAACATACTTCCCATC
ATCTGGGATTCAGGTGTTAGGGAGCCAGAGCCCCTTCCAAATCTCTCTCTCTTCATCTTC
CCTGGAAGCAAGGGGAGGAAGAAGTCAGAACCCAGAGGATGAGGTANNTANAGCAATCTC
AGTCCTTGTCTACCCGTTCATCCCTCAAAAATCTCTGGGTTCGAGGGAAGCAGGGAAGAA
ATAAGGGGCAAGGGGGGCTAGGGACTGGCCTCCAGGGCCCACTGCCAATAATGTCCCAGA
TAGCTATCCTTGTCTGTATCTCATCCCTAATAGGTACCATTGTCAGGCCTTGGGAGAGAG
AGGAAAAGCAGGTAGATGGTTCGAGAACCAAATGTGGTCTCCAGACTCTTTCCCAGAGTC
AGCAAAAGCCCTGGGGTGAACCCCAGGACTCTAGGAGCCACTCCTTTTCCCTCCAGCCCA
ACCAAGAGGTGAAAAGAAATTCCTTGGGACACAGCATCCCAAGCCACTCTTAAATCTCCA
CATCGCTTTCCTTGTCATTGTCATGGTCTCCATCATAGAACTCATTGGGTGCCTCTGGCC
TGCTATAGTTCTCCTCAGGACCCCTCTCCTCTGCATCAGCCTCATCAGTCCTGTCATAGG
TCAGGAGGTCTGCAGGCACGTCATGAATCTGGACACTAGGTGCATGGTTCAGCATCTTCA
GGTTTTCAAAGATTGTCTGGCGGATCTGGTCCAGATACTGGCGTGAGTTCTGATTCTCGA
TGCCGGTGCTGACATCTGGATGAAGTGTGAAGTCTGGGGCAAAGTACTCGAAGTATTCCC
TAT
Restriction Sites NotI-NotI |
ACCN NM_003883
Insert Size 2000 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_003883.2, NP_003874.2
RefSeq Size 1955 bp
RefSeq ORF 1287 bp
Locus ID 8841
UniProt ID O15379
Cytogenetics 5q31.3
Domains Hist_deacetyl
Protein Families Druggable Genome, Transcription Factors
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. provided by RefSeq, Jul 2008
Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
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Documents
Resources
"NM_003883" in other vectors (6)
SKU Description Size Price
RC200605 HDAC3 (Myc-DDK-tagged)-Human histone deacetylase 3 (HDAC3) 10 ug
$289.00 $457.00
RC200605L1 Lenti ORF clone of Human histone deacetylase 3 (HDAC3), Myc-DDK-tagged 10 ug
$757.00
RC200605L2 Lenti ORF clone of Human histone deacetylase 3 (HDAC3), mGFP tagged 10 ug
$757.00
RC200605L3 Lenti ORF clone of Human histone deacetylase 3 (HDAC3), Myc-DDK-tagged 10 ug
$757.00
RC200605L4 Lenti ORF clone of Human histone deacetylase 3 (HDAC3), mGFP tagged 10 ug
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RG200605 HDAC3 (tGFP-tagged) - Human histone deacetylase 3 (HDAC3) 10 ug
$489.00 $657.00

file-alt Citations

Aggregate-prone R120GCRYAB triggers multifaceted modifications of the Thioredoxin System
Banerjee Mustafi, Grose, Zhang et al
Antioxid. Redox Signal. (2013)
Cited by 9
AI Summary: OriGene products contributed to this study by providing CRYAB (Catalog No. SC118965) and HDAC3 (Catalog No. SC112704) gene constructs, which were used to investigate the roles of these proteins in the thioredoxin system and cardiac stress response.
Snippet: Wild-type human TRXR1 vector was obtained from ATCC (MGCI: 9145, GeneBank No. BC018122.1). CRYAB (Catalog No. SC118965, Accession number NM_001885) and HDAC3 (Catalog No SC112704, Accession No. NM_003883.2) constructs were obtained from Origene. A
Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model
Duncan, An, Papanikolaou et al
Mol Neurodegener (2013) 8, 42 DOI: 10.1186/1750-1326-8-42
Cited by 26
AI Summary: OriGene products, specifically the human ataxin-7 Myc-DDK-tagged cDNA clone, were used to express ataxin-7 in cell studies, enabling the researchers to investigate the interaction and posttranslational modification effects of HDAC3 on ataxin-7 in the context of spinocerebellar ataxia type 7.
FigureFigureFigure
Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells
Koon, Shih, Hing et al
Am. J. Pathol. (2011) 179 (5), 2315-26 DOI: 10.1016/j.ajpath.2011.07.038
Cited by 17
AI Summary: OriGene’s human CCN1 cDNA (clone TC310465) was used to overexpress CCN1 in mice, enabling the study of its effects on colitis and mucosal healing in this research.
Snippet: 16 Briefly, human CCN1 cDNA (clone TC310465;OriGene, Rockville, MD)- overexpressing construct mixed with a polyethyleneimine-based transfection reagent was intracolonically injected to anesthetized C57BL/6 mice. Mice
Showing 1-3 of 3 papers.
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