TRADD (NM_003789) Human Untagged Clone

SKU SC112703

TRADD (untagged)-Human TNFRSF1A-associated via death domain (TRADD)

Product Data

• Type: Human Untagged Clone
• Target Symbol: TRADD
• Synonyms: Hs.89862
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC112703 sequence for NM_003789 edited (data generated by NextGen Sequencing); ATGGCAGCTGGGCAAAATGGGCACGAAGAGTGGGTGGGCAGCGCATACCTGTTTGTGGAG; TCCTCGCTGGACAAGGTGGTCCTGTCGGATGCCTACGCGCACCCCCAGCAGAAGGTGGCA; GTGTACAGGGCTCTGCAGGCTGCCTTGGCAGAGAGCGGCGGGAGCCCGGACGTGCTGCAG; ATGCTGAAGATCCACCGCAGCGACCCGCAGCTGATCGTGCAGCTGCGATTCTGCGGGCGG; CAGCCCTGTGGCCGCTTCCTCCGCGCCTACCGCGAGGGGGCGCTGCGCGCCGCGCTGCAG; AGGAGCCTGGCGGCCGCGCTCGCCCAGCACTCGGTGCCGCTGCAACTGGAGCTGCGCGCC; GGCGCCGAGCGGCTGGACGCTTTGCTGGCGGACGAGGAGCGCTGTTTGAGTTGCATCCTA; GCCCAGCAGCCCGACCGGCTCCGGGATGAAGAACTGGCTGAGCTGGAGGATGCGCTGCGA; AATCTGAAGTGCGGCTCGGGGGCCCGGGGTGGCGACGGGGAGGTCGCTTCGGCCCCCTTG; CAGCCCCCGGTGCCCTCTCTGTCGGAGGTGAAGCCGCCGCCGCCGCCGCCACCTGCCCAG; ACTTTTCTGTTCCAGGGTCAGCCTGTAGTGAATCGGCCGCTGAGCCTGAAGGACCAACAG; ACGTTCGCGCGCTCTGTGGGTCTCAAATGGCGCAAGGTGGGGCGCTCACTGCAGCGAGGC; TGCCGGGCGCTGCGGGACCCGGCGCTGGACTCGCTGGCCTACGAGTACGAGCGCGAGGGA; CTGTACGAGCAGGCCTTCCAGCTGCTGCGGCGCTTCGTGCAGGCCGAGGGCCGCCGCGCC; ACGCTGCAGCGCCTGGTGGAGGCACTCGAGGAGAACGAGCTCACCAGCCTGGCAGAGGAC; TTGCTGGGCCTGACCGATCCCAATGGCGGCCTGGCCTAG; ; Clone variation with respect to NM_003789.3;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003789 unedited; GTTCAGATTTTNGTATACGACTTCACTATAGGCGGCNCGCGATTCGGCACGAGGGTAGAG; CGGAGCCTGGCGGGCGTGGGAACCCAGGCCCCGCCGAGGCGGCCAGGAGGTGAGATGGCA; GCTGGGCAAAATGGGCACGAAGAGTGGGTGGGCAGCGCATACCTGTTTGTGGAGTCCTCG; CTGGACAAGGTGGTCCTGTCGGATGCCTACGCGCACCCCCAGCAGAAGGTGGCAGTGTAC; AGGGCTCTGCAGGCTGCCTTGGCAGAGAGCGGCGGGAGCCCGGACGTGCTGCAGATGCTG; AAGATCCACCGCAGCGACCCGCAGCTGATCGTGCAGCTGCGATTCTGCGGGCGGCAGCCC; TGTGGCCGCTTCCTCCGCGCCTACCGCGAGGGGGCGCTGCGCGCCGCGCTGCAGAGGAGC; CTGGCGGCCGCGCTCGCCCAGCACTCGGTGCCGCTGCAACTGGAGCTGCGCGCCGGCGCC; GAGCGGCTGGACGCTTTGCTGGCGGACGAGGAGCGCTGTTTGAGTTGCATCCTAGCCCAG; CAGCCCGACCGGCTCCGGGATGAAGAACTGGCTGAGCTGGAGGATGCGCTGCGAAATCTG; AAGTGCGGCTCGGGGGCCCGGGGTGGCGACGGNGAGGTCGCTTCGGCCCCCTTGCAGCCC; CCGGTGCCCTCTCTGTCGGAGGTGAAGCCGNCGNCGNCGNCGCCACCTGCCCAGACTTTT; CTGTTCCAGGGTCAGCCTGTAGTGAATCGGCCGCTGAGCCTGAAGACCAACAGACGTTCG; CGCGCTCTGTGGGTCTCAAATGGCGCAAGGTGGGGCGCTCACTGCANCGAGGCTGCNCGG; CGCTGCGGAACCCNGCGCTGGACTCGCTGGCCTACGAGTCGAGCGCGAGGGACTGTACGA; GCAAGCCTTCCAGCTGCTGCGNGCCTTGTGCAG;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003789 unedited; TACCGCGGCACGCTTTTTAGNATCGAGTTTTTTTTTTTTTTTTTTATCCGTGTTATACTT; TATTATCATTGCTTAACATTCGGGGTCCCACGCTGAGTGTGAGCTGGGGGCAGGCAAGAT; TGATCCCTGTTTTACTTCACTGCAGCATCTGCAGCACCCAGGATGAAGTCCAGGACACCA; AAGATCAAGGTGCTTCATGAGTGAAACTGTAAGGGCTGGCTGTAAGCCCCGCTTTTGGGA; TGGGAGAAGGTGAGGCTGATCTACAAAGCAGGTCCCCCCCACCCCACACTCTATTAAAGT; ACCTGAGGCAGAATCCCCAATGATGCACCCCCAGTGGTCTGGCTCCTGGGGAAGGCAATT; AACTCTGTCCCAGTAGGCTCAGCAGATAGGCCAAGCGCAGTTCCAGGGCTCCGTGGCATG; GACAGGGGTTCACCCATAACCGTATAAGGAACCCTAAGGCCATCCAGGCTCTCCAAAACC; TGGCTGAACCCCTGGTCTAGGCCAGGTCGCCATTGGGATCGGCCAGGCCCAACAAGTTCT; CTGACCGGCTGGTGAGCTCGCTCCACTTTAGCGCCATCACCAGGCCCTTGCATTGCGGCG; CGGCGGCCCTCGACCTTGTTCCAACCCCGCATCTATCCGCAATGCCTGCCTTACACAGAC; CCTTCTCCTTGCACCTCCCGGCCCCTTTATCCCCATCCCCGGGTTCCCGCATTATTCCGC; CAGCCCTCCCTGACATGAGCCGCCCCCTCTCGTGTCATTCTTACCTCCCAAACACCCGCG; AACGCCTGTTTGCACCTTCAGCCTTCTGGATCCATTTATCACCCGTTCGTCCCTGTAACA; CCATATTTCGCCCGCCGCCCGCGCNGCCGTTGCTCTCACTCCCACCTACAGTTCTCGGCG; TTTTTGTGGCCTCCAACCACTTATCTTTCTCCCTGGCTCCACTATTCCTTTCTT;
• Restriction Sites: NotI-NotI
• ACCN: NM_003789
• Insert Size: 1590 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_003789.2, NP_003780.1
• RefSeq Size: 1482 bp
• RefSeq ORF: 939 bp
• Locus ID: 8717
• UniProt ID: Q15628
• Cytogenetics: 16q22.1
• Domains: DEATH
• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Apoptosis, RIG-I-like receptor signaling pathway
• Summary: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]; Transcript Variant: This variant (1) encodes a longer isoform (1).