SELS (SELENOS) (NM_018445) Human Untagged Clone
SKU
SC111961
VIMP (untagged)-Human selenoprotein S (SELS), transcript variant 2 (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below)
$429.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | SELS |
| Synonyms | AD-015; ADO15; SBBI8; SELS; SEPS1; VIMP |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_018445 |
| Insert Size | 1240 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). The expression of this clone is not guaranteed due to the nature of selenoproteins. |
| OTI Annotation | This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_018445.4, NP_060915.2 |
| RefSeq Size | 1250 bp |
| Locus ID | 55829 |
| UniProt ID | Q9BQE4 |
| Cytogenetics | 15q26.3 |
| Protein Families | Druggable Genome |
| Summary | This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). provided by RefSeq, Jul 2017 Transcript Variant: This variant (1) represents the predominant transcript, and encodes a selenocysteine-containing longer isoform (1). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_018445" in other vectors (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC200814 | VIMP (Myc-DDK-tagged)-Human selenoprotein S (SELS), transcript variant 2, (Note, selenocysteine protein, internal stop codon, see reference data summary) | 10 ug |
$118.00
|
|
| RC200814L1 | Lenti-ORF clone of VIMP (Myc-DDK-tagged)-Human selenoprotein S (SELS), transcript variant 2, (Note, selenocysteine protein, internal stop codon, see summary) | 10 ug |
$418.00
|
|
| RG200814 | VIMP (GFP-tagged) - Human selenoprotein S (SELS), transcript variant 2, (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below) | 10 ug |
$489.00
|
|
Citations
Selenoprotein S regulates adipogenesis through IRE1α-XBP1 pathway
Men, Yao, Yu et al
J. Endocrinol. (2020) 244 (3), 431-443 DOI: 10.1530/JOE-19-0292
Men, Yao, Yu et al
J. Endocrinol. (2020) 244 (3), 431-443 DOI: 10.1530/JOE-19-0292
Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency
Kelly, Greene, Carroll et al
J Biol Chem (2009) 284 (25), 16891-16897 DOI: 10.1074/jbc.M109.006288
Kelly, Greene, Carroll et al
J Biol Chem (2009) 284 (25), 16891-16897 DOI: 10.1074/jbc.M109.006288
AI Summary: OriGene products contributed to this study by providing the SEPS1 expression plasmid (OriGene, SC119827), which was used to overexpress SEPS1 in HepG2 cells to assess its effects on endoplasmic reticulum stress markers in Z variant alpha1-antitrypsin deficiency.
Showing 1-2 of 2 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
