Cyclophilin A (PPIA) (NM_021130) Human Untagged Clone
$225.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | Cyclophilin A |
| Synonyms | CYPA; CYPH; HEL-S-69p |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_021130 |
| Insert Size | 2290 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_021130.2, NP_066953.1 |
| RefSeq Size | 1652 bp |
| RefSeq ORF | 498 bp |
| Locus ID | 5478 |
| UniProt ID | P62937 |
| Cytogenetics | 7p13 |
| Domains | pro_isomerase |
| Summary | This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. provided by RefSeq, Jul 2008 Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_021130" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC203307 | PPIA (Myc-DDK-tagged)-Human peptidylprolyl isomerase A (cyclophilin A) (PPIA) | 10 ug |
$225.00
|
|
| RC203307L1 | Lenti ORF clone of Human peptidylprolyl isomerase A (cyclophilin A) (PPIA), Myc-DDK-tagged | 10 ug |
$525.00
|
|
| RC203307L2 | Lenti ORF clone of Human peptidylprolyl isomerase A (cyclophilin A) (PPIA), mGFP tagged | 10 ug |
$525.00
|
|
| RC203307L3 | Lenti ORF clone of Human peptidylprolyl isomerase A (cyclophilin A) (PPIA), Myc-DDK-tagged | 10 ug |
$525.00
|
|
| RC203307L4 | Lenti ORF clone of Human peptidylprolyl isomerase A (cyclophilin A) (PPIA), mGFP tagged | 10 ug |
$525.00
|
|
| RG203307 | PPIA (tGFP-tagged) - Human peptidylprolyl isomerase A (cyclophilin A) (PPIA) | 10 ug |
$489.00
|
|
Citations
BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells
Lavery, Swain, Falb et al
J Biol Chem (2008) 283 (30), 20948-58 DOI: 10.1074/jbc.M800850200
Lavery, Swain, Falb et al
J Biol Chem (2008) 283 (30), 20948-58 DOI: 10.1074/jbc.M800850200
AI Summary: OriGene products, specifically siRNAs targeting ACVR1A, BMPR1A, ACVR2A, BMPR2, BMPR1B, and ACVR2B, were used in this study to knock down individual BMP receptors and elucidate their distinct roles in BMP-induced osteoblastic differentiation of human mesenchymal stem cells.
BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells
Lavery, Swain, Falb et al
J Biol Chem (2008) 283 (30), 20948-58 DOI: 10.1074/jbc.M800850200
Lavery, Swain, Falb et al
J Biol Chem (2008) 283 (30), 20948-58 DOI: 10.1074/jbc.M800850200
AI Summary: OriGene products contributed to this study by providing specific siRNAs (OriGene, SR321082, SR304684, SR304685, SR303554, SR321083, SR321084) used for RNA interference-mediated gene knockdown of BMP receptors in human mesenchymal stem cells, enabling the authors to elucidate receptor-specific signaling mechanisms during osteoblastic differentiation.
GATA3 upregulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells
Fanis, Mori, Kurnat et al
Blood (2006)
Fanis, Mori, Kurnat et al
Blood (2006)
AI Summary: In the paper "GATA3 upregulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells," OriGene products, specifically the anti-GATA3 antibody (OriGene, TA308492) and GATA3 cDNA clone (OriGene, RC208307), were used for detecting and overexpressing GATA3 to investigate its association with CD294/CRTH2 expression in human T helper cells.
Showing 1-3 of 3 papers.
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