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PDCD4 (NM_014456) Human Untagged Clone

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SKU
SC111794
PDCD4 (untagged)-Human programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4), transcript variant 1
  $457.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol PDCD4
Synonyms H731
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC111794 sequence for NM_014456 edited (data generated by NextGen Sequencing)
ATGGATGTAGAAAATGAGCAGATACTGAATGTAAACCCTGCAGATCCTGATAACTTAAGT
GACTCTCTCTTTTCCGGTGATGAAGAAAATGCTGGGACTGAGGAAGTAAAGAATGAAATA
AATGGAAATTGGATTTCAGCATCCTCCATTAACGAAGCTAGAATTAATGCCAAGGCAAAA
AGGCGACTAAGGAAAAACTCATCCCGGGACTCTGGCAGAGGCGATTCGGTCAGCGACAGT
GGGAGTGACGCCCTTAGAAGTGGATTAACTGTGCCAACCAGTCCAAAGGGAAGGTTGCTG
GATAGGCGATCCAGATCTGGGAAAGGAAGGGGACTACCAAAGAAAGGTGGTGCAGGAGGC
AAAGGTGTCTGGGGTACACCTGGACAGGTGTATGATGTGGAGGAGGTGGATGTGAAAGAT
CCTAACTATGATGATGACCAGGAGAACTGTGTTTATGAAACTGTAGTTTTGCCTTTGGAT
GAAAGGGCATTTGAGAAGACTTTAACACCAATCATACAGGAATATTTTGAGCATGGAGAT
ACTAATGAAGTTGCGGAAATGTTAAGAGATTTAAATCTTGGTGAAATGAAAAGTGGAGTA
CCAGTGTTGGCAGTATCCTTAGCATTGGAGGGGAAGGCTAGTCATAGAGAGATGACATCT
AAGCTTCTTTCTGACCTTTGTGGGACAGTAATGAGCACAACTGATGTGGAAAAATCATTT
GATAAATTGTTGAAAGATCTACCTGAATTAGCACTGGATACTCCTAGAGCACCACAGTTG
GTGGGCCAGTTTATTGCTAGAGCTGTTGGAGATGGAATTTTATGTAATACCTATATTGAT
AGTTACAAAGGAACTGTAGATTGTGTGCAGGCTAGAGCTGCTCTGGATAAGGCTACCGTG
CTTCTGAGTATGTCTAAAGGTGGAAAGCGTAAAGATAGTGTGTGGGGCTCTGGAGGTGGG
CAGCAATCTGTCAATCACCTTGTTAAAGAGATTGATATGCTGCTGAAAGAATATTTACTC
TCTGGAGACATATCTGAAGCTGAACATTGCCTTAAGGAACTGGAAGTACCTCATTTTCAC
CATGAGCTTGTATATGAAGCTATTATAATGGTTTTAGAGTCAACTGGAGAAAGTACATTT
AAGATGATTTTGGATTTATTAAAGTCCCTTTGGAAGTCTTCTACCATTACTGTAGACCAA
ATGAAAAGAGGTTATGAGAGAATTTACAATGAAATTCCGGACATTAATCTGGATGTCCCA
CATTCATACTCTGTGCTGGAGCGGTTTGTAGAAGAATGTTTTCAGGCTGGAATAATTTCC
AAACAACTCAGAGATCTTTGTCCTTCAAGGGGCAGAAAGCGTTTTGTAAGCGAAGGAGAT
GGAGGTCGTCTTAAACCAGAGAGCTACTGA

Clone variation with respect to NM_014456.4
106 a=>g
5' Read Nucleotide Sequence
>OriGene 5' read for NM_014456 unedited
TTGATTTTGTAATACGACTCACTTATAGGGCGGCCGCGAATTCGCACGAGGAGAGACTCT
CCGAGGCGGCGGCAGAGACAGAAGAGCGGGGTCGGGGCCGGCTGACCAGGAACCTGGGCG
AGCAGCGGCGGGGGCCCGAGGGATTCTGAAGGAAGATTTCCATTAGGTAATTTGTTTAAT
CAGTGCAAGCGAAATTAAGGGAAAATGGATGTAGAAAATGAGCAGATACTGAATGTAAAC
CCTGCAGATCCTGATAACTTAAGTGACTCTCTCTTTTCCGGTGATGAAGAAAATGCTGGG
ACTGAGGAAGTAAAGAATGAAATAAATGGAAATTGGATTTCAGCATCCTCCATTAACGAA
GCTAGAATTAATGCCAAGGCAAAAAGGCGACTAAGGAAAAACTCATCCCGGGACTCTGGC
AGAGGCGATTCGGTCAGCGACAGTGGGAGTGACGCCCTTAGAAGTGGATTAACTGTGCCA
ACCAGTCCAAAGGGAAGGTTGCTGGATAGGCGATCCAGATCTGGGAAAGGAAGGGGACTA
CCAAAGAAAGGTGGTGCATGAGGCAAAGGTGTCTGGGGTACACCTGGACAGGTGTATGAT
GTGGAGGAGGTGGATGTGAAAGATCCTAACTATGATGATGACCAGGAGAACTGTGTTTAT
GAAACTGTAGTTNTGCCTTTGGATGAAAGGGCATTTGAGAAGACTTTAACACCAATCATA
CAGGAATATTTTGAGCATGGAGATACCTAATGAAGNTGCNGAAATGTTAANAGATTTAAA
TCTTGGTGAAATGAANAGTGGAGTACCAGTGTTGGGCAGTATCCCTTANCATTGGAGGGG
AANNGGCTAGTCATAGAGAGATGACATCTAAAGCTCTTTTCTGACCTTTGTGGNNACAGT
ATGAGCACCACTGATGTGGGAAAATCATTTGATAAANTGTGGAAGGACTACCTGAATTAC
ACTGGAACTCCTANACACCACAGTTGGTGGCCATTATGGCTANACTGGTGA
3' Read Nucleotide Sequence
>OriGene 3' read for NM_014456 unedited
GTACGCGGCCGCAATCTACAGTCGAGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAAA
AAATCAATACTGCTTCACATGTTTTATTTTGGGGCACATTCTTCTAAAACCAGGTTCATT
TTTCCAGTTTTGTACAAAAATAGATGTTCCAGCCACCTTTTACTTAACTGGCTACCCTTT
TAAAACCAATCATTATGTCCCCTGGAAAGATGAATAAGTCTCATGACTAATTTTTTAAAA
ATTCTTTACGACAAAGAAATAACTTTCTTTTTTTACTCCCAAAGCACAGGTTCTCAACAG
CAGCAGCCAACATGGGGTTTTATAAGTTTAACTTTACCCCCTAAATAAAGCCTTTGTATA
AACCACGGATTTTACTACAAAAAACACTGTCCTTGAAAGAAAGGAGTGGCACTCAGACAT
CAATGCAAAACTTGGAATGATTCGATCATAAACATGGCACTTACAAAAGGTAGCTTATTA
AAATATCCCACTTAAAAAGAGGTCTACCTCTCTGGCCCTCCTTGCCCCCTCGAAACCCAA
CCAACCCACAAACATTTCCTTTTAAAATTCCCCTTAAATGTGGCTTATAAAATGTCAGAA
ATGCCTTGCCCCCAATACAACTGCTTTAAAAAAAAAAAAAAAACCCTGGGCCACACCCCT
TTTCCCCTTCAAATTCTTATTTTCTATTACCACCCACAATCGGACGAGTTTCCTATTCTC
AACTCCTCTCTCGGTCACACACAAACCTCACTCCTCCTTCATTCACAAATAGTTTTCTTC
GCCCCTTCACAGGTACCAAATATTTCGTGGACCGCCTGGGGAAATTATTCCACTCGCGAG
AAATCTTNTTTCCCAACAACCCGTTCCACGCCAGAACAGTTCAATGTGGGCCCCTTCAAC
ATATTCTGGCCCCGATATTCTTTTGTTCATTT
Restriction Sites NotI-NotI |
ACCN NM_014456
Insert Size 2640 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_014456.3, NP_055271.2
RefSeq Size 3591 bp
RefSeq ORF 1410 bp
Locus ID 27250
UniProt ID Q53EL6
Cytogenetics 10q25.2
Domains MA3
Protein Families Druggable Genome
Summary This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. provided by RefSeq, Dec 2010
Transcript Variant: This variant (1) encodes the longest isoform (1).
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Documents
Resources
"NM_014456" in other vectors (6)
SKU Description Size Price
RC206016 PDCD4 (Myc-DDK-tagged)-Human programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4), transcript variant 1 10 ug
$457.00
RC206016L1 Lenti ORF clone of Human programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4), transcript variant 1, Myc-DDK-tagged 10 ug
$757.00
RC206016L2 Lenti ORF clone of Human programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4), transcript variant 1, mGFP tagged 10 ug
$757.00
RC206016L3 Lenti ORF clone of Human programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4), transcript variant 1, Myc-DDK-tagged 10 ug
$757.00
RC206016L4 Lenti ORF clone of Human programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4), transcript variant 1, mGFP tagged 10 ug
$757.00
RG206016 PDCD4 (tGFP-tagged) - Human programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4), transcript variant 1 10 ug
$489.00 $657.00

file-alt Citations

PDCD4 is an androgen-repressed tumor suppressor that regulates prostate cancer growth and castration resistance
Zennami, Choi, Liao et al
Mol. Cancer Res. (2018)
AI Summary: OriGene’s pCMV6-XL5-PDCD4 plasmid (SC111794) was used in this study to overexpress PDCD4 and investigate its role in regulating prostate cancer cell growth, apoptosis, and castration resistance.
Snippet: and Bicalutamide (Sigma-Aldrich, St Louis, MO, USA) was dissolved in dimethyl sulfoxide and stored at -20 °C. pCMV6-XL5-PDCD4 (SC111794) was purchased from OriGene Technologies Inc. (Rockville, MD, USA). pCMV6-EV was generated by PDCD4
CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation
Pisano, Ceglia, Palmieri et al
J. Biol. Chem. (2015)
AI Summary: OriGene products pCMV6-IBtkα-FLAG (RC218657) and pCMV6-XL5-Pdcd4 plasmids were used to express IBtkα and Pdcd4 proteins, enabling the study of their interaction and regulation in the paper.
Snippet: proteasome. EXPERIMENTAL PROCEDURES Plasmids, siRNAs, lentiviruses and antibodies – pCMV6-IBtkα-FLAG (RC218657, IBtkα 1-1352) and pCMV6-XL5-Pdcd4 were from OriGene Technologies, Inc. (Rockville, MD USA). ... Cite SaveSaving
Showing 1-2 of 2 papers.
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