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DUSP10 (NM_007207) Human Untagged Clone

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SKU
SC111766
DUSP10 (untagged)-Human dual specificity phosphatase 10 (DUSP10), transcript variant 1
  $457.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol DUSP10
Synonyms MKP-5; MKP5
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC111766 sequence for NM_007207 edited (data generated by NextGen Sequencing)
ATGCCTCCGTCTCCTTTAGACGACAGGGTAGTAGTGGCACTATCTAGGCCCGTCCGACCT
CAGGATCTCAACCTTTGTTTAGACTCTAGTTACCTTGGCTCTGCCAACCCAGGCAGTAAC
AGCCACCCTCCTGTCATCGCCACCACCGTTGTGTCCCTCAAGGCTGCGAATCTGACGTAT
ATGCCCTCATCCAGCGGCTCTGCCCGCTCGCTGAATTGTGGATGCAGCAGTGCCAGCTGC
TGCACTGTGGCAACCTACGACAAGGACAATCAGGCCCAAACCCAAGCCATTGCCGCTGGC
ACCACCACCACTGCCATCGGAACCTCTACCACCTGCCCTGCTAACCAGATGGTCAACAAT
AATGAGAATACAGGCTCTCTAAGTCCATCAAGTGGGGTGGGCAGCCCTGTGTCAGGGACC
CCCAAGCAGCTAGCCAGCATCAAAATAATCTACCCCAATGACTTGGCAAAGAAGATGACC
AAATGCAGCAAGAGTCACCTGCCGAGTCAGGGCCCTGTCATCATTGACTGCAGGCCCTTC
ATGGAGTACAACAAGAGTCACATCCAAGGAGCTGTCCACATTAACTGTGCCGATAAGATC
AGCCGGCGGAGACTGCAGCAGGGCAAGATCACTGTCCTAGACTTGATTTCCTGTAGGGAA
GGCAAGGACTCTTTCAAGAGGATCTTTTCCAAAGAAATTATAGTTTATGATGAGAATACC
AATGAACCAAGCCGAGTGATGCCCTCCCAGCCACTTCACATAGTCCTCGAGTCCCTGAAG
AGAGAAGGCAAAGAACCTCTGGTGTTGAAAGGTGGACTTAGTAGTTTTAAGCAGAACCAT
GAAAACCTCTGTGACAACTCCCTCCAGCTCCAAGAGTGCCGGGAGGTGGGGGGCGGCGCA
TCCGCGGCCTCGAGCTTGCTACCTCAGCCCATCCCCACCACCCCTGACATCGAGAACGCT
GAGCTCACCCCCATCTTGCCCTTCCTGTTCCTTGGCAATGAGCAGGATGCTCAGGACCTG
GACACCATGCAGCGGCTGAACATCGGCTACGTCATCAACGTCACCACTCATCTTCCCCTC
TACCACTATGAGAAAGGCCTGTTCAACTACAAGCGGCTGCCAGCCACTGACAGCAACAAG
CAGAACCTGCGGCAGTACTTTGAAGAGGCTTTTGAGTTCATTGAGGAAGCTCACCAGTGT
GGGAAGGGGCTTCTCATCCACTGCCAGGCTGGGGTGTCCCGCTCCGCCACCATCGTCATC
GCTTACTTGATGAAGCACACTCGGATGACCATGACTGATGCTTATAAATTTGTCAAAGGC
AAACGACCAATTATCTCCCCAAACCTTAACTTCATGGGGCAGTTGCTAGAGTTCGAGGAA
GACCTAAACAACGGTGTGACACCGAGAATCCTTACACCAAAGCTGATGGGCGTGGAGACG
GTTGTGTGA

Clone variation with respect to NM_007207.4
5' Read Nucleotide Sequence
>OriGene 5' read for NM_007207 unedited
GTTAGATTTTATACACTATTAGGCGGCCGCGATTCGCCGAGGACAATGAACCGATGATGG
GGGCTGAATGTGCGAGTCCATAGCTGAAGAGGAGCGCCAGATGGTGGAGGAATACACTTA
TTTATGAAACTGTCTTGAGTTCTTCTTGAATTGCCAGTTTTCAGCCTCCTCATGCCTCCG
TCTCCTTTAGACGACAGGGTAGTAGTGGCACTATCTAGGCCCGTCCGACCTCAGGATCTC
AACCTTTGTTTAGACTCTAGTTACCTTGGCTCTGCCAACCCAGGCAGTAACAGCCACCCT
CCTGTCATCGCCACCACCGTTGTGTCCCTCAAGGCTGCGAATCTGACGTATATGCCCTCA
TCCAGCGGCTCTGCCCGCTCGCTGAATTGTGGATGCAGCAGTGCCAGCTGCTGCACTGTG
GCAACCTACGACAAGGACAATCAGGCCCAAACCCAAGCCATTGCCGCTGGCACCACCACC
ACTGCCATCGGAACCTCTACCACCTGCCCTGCTAACCAGATGGTCAACAATAATGAGAAT
ACAGGCTCTCTAAGTCCATCAAGTGGGGTGGGCAGCCCTGTGTCAGGGACCCCCAAGCAG
CTAGCCAGCATCAAAATAATCTACCCCAATGACTTGGCAAAGAAGATGACCAAATGCAGC
AAGAGTCACCTGCCGAGTCANGGCCCTGTCATCATTGACTGCAGGCCCTTCATGGAGTAC
AACAAGAGTCACATCCAAGGAGCTGTCCACATTAACTGTGCCGNATAGATCAGCCGGCGG
AGACTGCAGCAGGGCAAGATCACTGTCCTAGACTTGATTTCCTGTAGGGAAAGGCAGGAC
TCTTTCAAGAGATCTTTTCAAAGAAATTATAGTTATGATGAGATACCCATGACCAAGCCG
ATGATGCCCTT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_007207 unedited
TCTATGGACCGCGGCCCGCATTTCTAAAGTCGAGTTTTTTTTTTTTTTTTTTGCGAAAAA
ATTTTTAAATAAATTTTTTTTTCTTACATTCTGATATACATATGTAACAAGGTTTATGGC
ACTGTAACCAGAATCAAATCAGAAAAAAAAAAAAAAAGGAAAAAGGTGGGAAGGAAAGTA
TTTGATATATTGTTGAATTCCTTTCTATCTCCAAGCTGGCAAATTTGCACTATTTGTCTA
TCATTCAGCTGCCAGCTCTAACTTGTTTGCACACTTAAAACATCATATTATTGCACAAGA
AGCCAGTGAAGGCATATAATGGTCAGTTCCTCACTATTTCAAAAAAAATCTCTTAAACCC
AGAGAAGGAAAAAAAAAAAAAAAATCCAGAGCATGAAACACACAAAATCAAAGGTATCCT
TTTTCTCCTTAAAGAATGCCTGAAGGATTCTTAAACCACTTAAGCTGCCCTGATCTTCTC
TTTGCACCAGTGAGCACAACAGGGCTTGGTTTGGTTGGGTTTTTGTTTTCTGTGTGGACA
GCCCAGGTTGATCCCAGGCCTTGGAGATTCAATGTCTTTTCTATTTACTTTTGGTTCTTT
TTAATTGGTTTAAAGTGTGTAGTATCTTCGGTCTATGAACCTGCACAGACTATTTAGTCA
TAAACTCTACAAATAGCTTAAAAGGAAAAGGGGGAGAAACAAGTTGTATTATATTTTTAT
TGTTGGCTTAAAAAATTACTTCTTTAACCTCCTTAATTTGNCAGTTTNGTGGGAAGTGAA
TCTCAATGGCATCAAAAGCTATAGTCTTCCTACACTTGTTAANNATNAAGTGTTAAANNC
AGTTTGTTCCATTTCACAACTTACTCCCCACCTCANNAAAAAAAGAAAGAAAAAACCCGA
ACCCTCCTCCCTCCTCATGCCTCCTAATGGAGAGCAGCATCCTTTTCATTNCAGACATTG
TNACACAACGTNNTCACGCCATAGCTTTGTTGAAGGATT
Restriction Sites NotI-NotI |
ACCN NM_007207
Insert Size 2750 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_007207.3, NP_009138.1
RefSeq Size 2619 bp
RefSeq ORF 1449 bp
Locus ID 11221
UniProt ID Q9Y6W6
Cytogenetics 1q41
Domains DSPc, RHOD
Protein Families Druggable Genome, Phosphatase
Protein Pathways MAPK signaling pathway
Summary Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. provided by RefSeq, Apr 2014
Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
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Documents
Resources
"NM_007207" in other vectors (7)
SKU Description Size Price
RC206760 DUSP10 (Myc-DDK-tagged)-Human dual specificity phosphatase 10 (DUSP10), transcript variant 1 10 ug
$457.00
RC206760L1 Lenti ORF clone of Human dual specificity phosphatase 10 (DUSP10), transcript variant 1, Myc-DDK-tagged 10 ug
$757.00
RC206760L2 Lenti ORF clone of Human dual specificity phosphatase 10 (DUSP10), transcript variant 1, mGFP tagged 10 ug
$757.00
RC206760L3 Lenti ORF clone of Human dual specificity phosphatase 10 (DUSP10), transcript variant 1, Myc-DDK-tagged 10 ug
$757.00
RC206760L4 Lenti ORF clone of Human dual specificity phosphatase 10 (DUSP10), transcript variant 1, mGFP tagged 10 ug
$757.00
RG206760 DUSP10 (tGFP-tagged) - Human dual specificity phosphatase 10 (DUSP10), transcript variant 1 10 ug
$489.00 $657.00
SC322594 DUSP10 (untagged)-Human dual specificity phosphatase 10 (DUSP10), transcript variant 1 10 ug
$457.00

file-alt Citations

DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression
Jiménez-Martínez, Ostalé, van der Burg et al
Cancers (Basel) (2019) 11 (11) DOI: 10.3390/cancers11111767
AI Summary: OriGene’s Human DUSP10 cDNA (SC31766) was used to generate DUSP10-overexpressing colorectal cancer cell lines, enabling the study of DUSP10’s role in promoting cell proliferation and colorectal cancer progression.
Snippet: DUSP10 overexpressing and DUSP10 knockdown cell lines were generated by lentiviral particle transduction carrying construct genes or empty vector/scramble basically as described elsewhere [34]. … Human DUSP10 cDNA (SC31766, OriGene Technologies, Rockville, MD, USA) was subcloned in the pLenti-CMV/TO-Hygro vector using specific primers. …
Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells
Wu, Mei, Vlassara et al
Am J Physiol Renal Physiol (2009) 297 (6), F1622-31 DOI: 10.1152/ajprenal.00078.2009
Cited by 78
AI Summary: In this study, OriGene products—specifically the MKP5 cDNA clone and MKP5 siRNA—were used to manipulate MKP5 expression in mesangial cells, enabling the authors to demonstrate that MKP5 regulates JNK activation and the proinflammatory phenotype associated with aging diabetic nephropathy.
Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells
Wu, Mei, Vlassara et al
Am J Physiol Renal Physiol (2009) 297 (6), F1622-31 DOI: 10.1152/ajprenal.00078.2009
Cited by 78
AI Summary: In this study, OriGene’s mouse MKP5 cDNA clone (Cat# MC204727) and MKP5 shRNA plasmid (Cat# TL502431) were used to overexpress and knock down MKP5 in mesangial cells, respectively, enabling the authors to demonstrate MKP5’s regulatory role in JNK activation and the proinflammatory phenotype of aging diabetic mesangial cells.
Showing 1-3 of 3 papers.
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