OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

REA (PHB2) (NM_007273) Human Untagged Clone

Be the first to review this product
SKU
SC111193
PHB2 (untagged)-Human prohibitin 2 (PHB2), transcript variant 2
  $300.00
2 Weeks*
Bulk Requests & Clone Modifications

Frequently Bought Together (4)

TA308685 Rabbit Polyclonal antibody to Prohibitin 2 (prohibitin 2)
100 ul
$665.00
CC100003 DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
5 x 200 ul
$170.00
PRIMER Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
100 pmol
$59.00
TF81001 TurboFectin Transfection Reagent (1 mL in 1 vial)
1 ml in 1 vial
$530.00

Other products for "REA or NM_007273"

Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol REA
Synonyms BAP; Bap37; BCAP37; p22; PNAS-141; REA
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>NCBI ORF sequence for NM_007273, the custom clone sequence may differ by one or more nucleotides


ATGGCCCAGAACTTGAAGGACTTGGCGGGACGGCTGCCCGCCGGGCCCCGGGGCATGGGCACGGCCCTGA
AGCTGTTGCTGGGGGCCGGCGCCGTGGCCTACGGTGTGCGCGAATCTGTGTTCACCGTGGAAGGCGGGCA
CAGAGCCATCTTCTTCAATCGGATCGGTGGAGTGCAGCAGGACACTATCCTGGCCGAGGGCCTTCACTTC
AGGATCCCTTGGTTCCAGTACCCCATTATCTATGACATTCGGGCCAGACCTCGAAAAATCTCCTCCCCTA
CAGGCTCCAAAGACCTACAGATGGTGAATATCTCCCTGCGAGTGTTGTCTCGACCCAATGCTCAGGAGCT
TCCTAGCATGTACCAGCGCCTAGGGCTGGACTACGAGGAACGAGTGTTGCCGTCCATTGTCAACGAGGTG
CTCAAGAGTGTGGTGGCCAAGTTCAATGCCTCACAGCTGATCACCCAGCGGGCCCAGGTATCCCTGTTGA
TCCGCCGGGAGCTGACAGAGAGGGCCAAGGACTTCAGCCTCATCCTGGATGATGTGGCCATCACAGAGCT
GAGCTTTAGCCGAGAGTACACAGCTGCTGTAGAAGCCAAACAAGTGGCCCAGCAGGAGGCCCAGCGGGCC
CAATTCTTGGTAGAAAAAGCAAAGCAGGAACAGCGGCAGAAAATTGTGCAGGCCGAGGGTGAGGCCGAGG
CTGCCAAGATGCTTGGAGAAGCACTGAGCAAGAACCCTGGCTACATCAAACTTCGCAAGATTCGAGCAGC
CCAGAATATCTCCAAGACGATCGCCACATCACAGAATCGTATCTATCTCACAGCTGACAACCTTGTGCTG
AACCTACAGGATGAAAGTTTCACCAGGGGAAGTGACAGCCTCATCAAGGGTAAGAAATGA

5' Read Nucleotide Sequence
>OriGene 5' read for NM_007273 unedited
TTTGTAAACGACTCACTATAGGCGGCCCGCGAATTCGCACGAGGCTTTCGCCAGCCTTAC
GGGCCCGAACCCTCGTGTGAAGGGTGCAGTACCTAAGCCGGAGCGGGGTAGAGGCGGGCC
GGCACCCCCTTCTGACCTCCAGTGCCGCCGGCCTCAAGATCAGACATGGCCCAGAACTTG
AAGGACTTGGCGGGACGGCTGCCCGCCGGGCCCCGGGGCATGGGCACGGCCCTGAAGCTG
TTGCTGGGGGCCGGCGCCGTGGCCTACGGTGTGCGCGAATCTGTGTTCACCGTGGAAGGC
GGGCACAGAGCCATCTTCTTCAATCGGATCGGTGGAGTGCAGCAGGACACTATCCTGGCC
GAGGGCCTTCACTTCAGGATCCCTTGGTTCCAGTACCCCATTATCTATGACATTCGGGCC
AGACCTCGAAAAATCTCCTCCCCTACAGGCTCCAAAGACCTACAGATGGTGAATATCTCC
CTGCGAGTGTTGTCTCGACCCAATGCTCAGGAGCTTCCTAGCATGTACCAGCGCCTAGGG
CTGGACTACGAGGAACGAGTGTTGCCGTCCATTGTCAACGAGGTGCTCAAGAGTGTGGTG
GCCAAGTTCAATGCCTCACAGCTGATCACCCAGCGGGCCCAGGTATCCCTGGTTGATCCG
CCGGGAGCTGACAGAGAGGGCCAAGGACTTCAGCCTCATCCTGGATGATGTGGCCATCAC
AGAGCTGAGCTTTAGCCGAGAGTACACAGCTGCTGTAGAAGCAAACAAGTGGCCCAGCAG
GAGGCCCCAGCGGCCCCCATTCTTGGTAGAAAAAGCAAGCANGAACAGCGCAGAAAATGT
GCAGCCCCAGGGTGAGGCCCGAGCTGCCAAATGCTTGGAGAACACTGAGCAGAACCTGCT
ACACAACTTGCAGAATT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_007273 unedited
CTTTGGACCGGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTCAGGTTAAGT
AATAAAAATTATTGAGAATTCCTGGGTTGGTGTTTATCTCCTCCCAGCCTTGAGGGAGGG
AACAACACTGTAGGAAATCACTTGAGAAATCACGCACTGTCCCCAACAGCCCCAGTTAAC
ACAGGGAGGAGGAAAGTAATTCCCCAGAAAAGGGGCTAGTCTTCAGTCTTCCTTAATCCA
AGAGGGGTTCAGGGAACCGGTGTGGGGGACCATCGCATGATACTGGGGCGGGGTAGGGCT
GTGCTGGACCCCTGGCTGGCTCCTCAAAAACTGGAGAAGCAGATCCACTTCCTCTGGGGG
TGGAGTTCTTGGTGACTAGGCTCATTTCTTACCCTTGATGAGGCTGTCACTTCCCCTGGT
GAAACTTTCATCCTGTAGGTTCAGCACAAGGTTGTCAGCTGTGAGATAGATACGATTCTG
TGATGTGGCGATCGTCTTGGAGATATTCTGGGCTGCTCGAATCTTGCGAAGTTTGATGTA
GCCAGGGTTCTTGCTCAGTGCTTCTCCAAGCATCTTGGCAGCCTCGGCCTCACCCTCGGC
CTGCACAATTTTCTGCCGCTGTTCCTGCTTTGCTTTTTCTACCAAGAATTGGGCCCGCTG
GGCCTCCTGCTGGGCCACTTGTTTGGCTTCTACAGCAGCTGTGTACTCTCGGCTAAAGCT
CAGCTCTGTGATGGCCACATCATCCAGGATGAGGCTGAAGTCCTTGGCCCTCTCTGTCAG
CTCCGGNCGGATCAACAGGNATACCTNGGCCCGCTGGTGATCAGCTGTGAGCATTGAACT
TGCCACCACACTCTTGAGCACCTCGTGACATGGACGGCACACTCGTTCTCGTAGTCAGCC
TAGCGCTGNTACATGCTAGAGCTCTGACATTGGTCAGACACCTGCAGGAGATATACTCTG
TAGCTTTGACTGA
Restriction Sites NotI-NotI |
ACCN NM_007273
Insert Size 1400 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_007273.3, NP_009204.1
RefSeq Size 1416 bp
RefSeq ORF 900 bp
Locus ID 11331
Cytogenetics 12p13.31
Domains Band_7
Protein Families Druggable Genome, Transcription Factors
Summary Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514).UniProtKB/Swiss-Prot Function
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources
"NM_007273" in other vectors (6)
SKU Description Size Price
RC210710 PHB2 (Myc-DDK-tagged)-Human prohibitin 2 (PHB2), transcript variant 2 10 ug
$300.00
RC210710L1 Lenti ORF clone of Human prohibitin 2 (PHB2), transcript variant 2, Myc-DDK-tagged 10 ug
$600.00
RC210710L2 Lenti ORF clone of Human prohibitin 2 (PHB2), transcript variant 2, mGFP tagged 10 ug
$600.00
RC210710L3 Lenti ORF clone of Human prohibitin 2 (PHB2), transcript variant 2, Myc-DDK-tagged 10 ug
$600.00
RC210710L4 Lenti ORF clone of Human prohibitin 2 (PHB2), transcript variant 2, mGFP tagged 10 ug
$600.00
RG210710 PHB2 (tGFP-tagged) - Human prohibitin 2 (PHB2), transcript variant 2 10 ug
$489.00 $500.00

file-alt Citations

Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans
Zubovych, Straud, Roth
Mol Biol Cell (2010) 21 (6), 956-69 DOI: 10.1091/mbc.e09-08-0673
Cited by 57
AI Summary: OriGene’s phb-2 (Cat# KN402932), har-1 (Cat# KN401973), and spg-7 (Cat# KN402810) gene-specific products were used to identify and characterize mitochondrial mutations that confer multi-drug resistance in Caenorhabditis elegans.
FigureFigureFigure
A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance
Zubovych, Doundoulakis, Harran et al
Proc Natl Acad Sci U S A (2006) 103 (42), 15523-8 DOI: 10.1073/pnas.0607338103
Cited by 18
AI Summary: OriGene products contributed to this study by providing the anti-PHB2 antibody (Cat# TA324933), which was used for protein detection and analysis to investigate the role of prohibitin 2 in multidrug resistance in Caenorhabditis elegans.
Showing 1-2 of 2 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products