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SCO2 (NM_005138) Human Untagged Clone

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SKU
SC111130
SCO2 (untagged)-Human SCO cytochrome oxidase deficient homolog 2 (yeast) (SCO2), nuclear gene encoding mitochondrial protein, transcript variant 1
  $300.00
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol SCO2
Synonyms CEMCOX1; ECGF1; Gliostatin; MC4DN2; MYP6; PD-ECGF; SCO1L; TdRPase; TP; TYMP
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>OriGene ORF within SC111130 sequence for NM_005138 edited (data generated by NextGen Sequencing)
ATGCTGCTGCTGACTCGGAGCCCCACAGCTTGGCACAGGCTCTCTCAGCTCAAGCCTCCG
GTCCTCCCTGGGACCCTGGGAGGCCAGGCCCTGCATCTGAGGTCCTGGCTTTTGTCAAGG
CAGGGCCCTGCAGAGACAGGTGGGCAGGGCCAGCCCCAGGGCCCTGGGCTTCGAACCCGG
CTGCTGATCACAGGCCTGTTCGGGGCTGGACTCGGTGGGGCCTGGCTGGCCCTGAGGGCT
GAGAAGGAGAGGCTGCAGCAGCAAAAGCGAACAGAAGCCCTGCGCCAGGCAGCTGTGGGC
CAGGGCGACTTCCACCTGCTGGATCACAGAGGCCGGGCTCGCTGCAAGGCTGACTTCCGG
GGCCAGTGGGTGCTGATGTACTTTGGCTTCACTCACTGCCCTGACATCTGCCCAGACGAG
CTGGAGAAGCTGGTGCAGGTGGTGCGGCAGCTGGAAGCAGAGCCTGGTTTGCCTCCAGTG
CAGCCTGTCTTCATCACTGTGGACCCCGAGCGGGACGACGTTGAAGCCATGGCCCGCTAC
GTCCAGGACTTCCACCCAAGACTGTTGGGTCTGACCGGCTCCACCAAACAGGTTGCCCAG
GCTAGTCACAGTTACCGCGTGTACTACAATGCCGGCCCCAAGGATGAGGACCAGGACTAC
ATCGTGGACCACTCCATTGCCATCTACCTGCTCAACCCTGACGGCCTCTTCACGGATTAC
TACGGCCGGAGCAGATCGGCTGAGCAGATCTCAGACAGTGTGCGGCGGCACATGGCGGCT
TTCCGCAGTGTCCTGTCTTGA

Clone variation with respect to NM_005138.2
59 g=>c;633 a=>c
5' Read Nucleotide Sequence
>OriGene 5' read for NM_005138 unedited
CAGAATTTTGTAATACGACTCACTATAGGGCGGCCCGCGATTCGGCACGAGGCAAATAGA
TAACGTGGTTAGTTCAGGCAAGGCATGCACTTGGAATGCTTTCCGTCAGCAAGAGGTTCA
CCTTGCTGAGGTGCAGGTGCAGGTGCAGGGCAGGGTGCGGTGACAGGCTGGTGATCCCAG
GTAGAGGACAGGAGTGACAGGTGTGGTTGCCCAGGTGTGGATGTTTGGTGGAGGTGGAGT
TCTGAGCTCAGGTGAGCAGCTGCAAATGCCTGTTAAGCCTGAACGTGGGCTGGGTACTTC
AGATGGGTGGCTGGTCTCAAGTCGCAGGGGCAGCCCAGGCACTGTCCTGGGCCTTCCCTT
CTGGCTCCTGACGCCTGTGCTTGTTTCCAGGAGCATCAGATCCATGCTGCTGCTGACTCG
GAGCCCCACAGCTTGGCACAGGCTCTCTCAGCTCAAGCCTCCGGTCCTCCCTGGGACCCT
GGGAGGCCAGGCCCTGCATCTGAGGTCCTGGCTTTTGTCAAGGCAGGGCCCTGCAGAGAC
AGGTGGGCAGGGCCAGCCCCAGGGCCCTGGGCTTCGAACCCGGCTGCTGATCACAGGCCT
GTTCGGGGCTGGACTCGGTGGGGCCTGGCTGGCCCTGAGGGCTGAGAAGGAGAGGCTGCA
GCAGCAAAAGCGAACAGAAGCCCTGCGCCAGGCAGCTGTGGGCCAGGGCGACTTCCACCT
GCTGGNATCACAGAGCCGGGCTCGCTGCAAGGCTGACTTCCGGGGCCAGTGGGTGCTGAT
GTACTTTGGCTNACTCACTGCCCTGACATCTGCCCAAACGAGCTGNANAANNCTGTGCAN
GTGGTGCCGCANCTGAANCANAGCCTGTNTNGCCTCCAT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_005138 unedited
CCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTAAACGCAGCCCGTTTAAT
GATGGGGCCCAGACTGCAGTGGCTCAAGACAGGACACTGCGGAAAGCCGCCATGTGCCGC
CGCACACTGTCTGAGATCTGCTCAGCCGATCTGCTCCGGCCGTAGTAATCCGTGAAGAGG
CCGTCAGGGTTGAGCAGGTAGATGGCAATGGAGTGGTCCACGATGTAGTCCTGGTCCTCA
TCCTTGGGGCCGGCATTGTAGTACACGCGGTAACTGTGACTAGCCTGGGCAACCTGTTTG
GTGGAGCCGGTCAGACCCAACAGTCTTGGGTGGAAGTCCTGGACGTACCGGGCCATGGCT
TCAACGTCGTCCCGCTCGGGGTCCACAGTGATGAACACAGGCTGCACTTGGAGCAAACCA
GGCTCTGCTTCCAGCTGCCGCACCACCTGCACCACTTTTTCCACCTTGCTCTGGCCATAT
GTTAGGGGCACTGATGCGACCCTAAGTTCATTCTTCCTCCCCTGATTTCCGGAATTACCT
CCTCTTTCACCCCGATCCTTTGCTATCTAATTCCCGCAACCAATAATTCCTCTCTACGCC
CCGGATATCGCCCCATTCCCCTTTTCCTTGTCCACATCTTCTCCTCCCCCGCTCTTTTCC
CCCTCCATTTCCCTCTCCCCGTATTTCTGTTCCCCCCCCGTTTCGCTCCGGCCTTCCTAG
TATACACCCCCTTCTCTCTTCACCTCTCTCCGCCCTCTCGCCCGTCCCCCAACTCTCCCT
TACCCACCCATCCCTCCCCTCCTTCCATTCCACCCCCCCCTCCTCCCCCCTTTCCGTCAT
CTCCCTCCTTCTCTCTCCTCCCCCTCTTTCTTCCCCCGCCCCACCCTATTCCCGACTTCC
CTCCGTCNTATCTCCATCCCTTCTCTCCCCATGTTATTATTTCTCCGACTCCCCTATCTC
ATTCTCCCTGACCTCC
Restriction Sites NotI-NotI |
ACCN NM_005138
Insert Size 1310 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_005138.1, NP_005129.1
RefSeq Size 931 bp
RefSeq ORF 801 bp
Locus ID 9997
UniProt ID O43819
Cytogenetics 22q13.33
Domains SCO1-SenC
Protein Families Druggable Genome
Summary Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. provided by RefSeq, Oct 2014
Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2, 3 and 4 encode the same protein.
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Documents
Resources
"NM_005138" in other vectors (4)
SKU Description Size Price
RC211837 SCO2 (Myc-DDK-tagged)-Human SCO cytochrome oxidase deficient homolog 2 (yeast) (SCO2), nuclear gene encoding mitochondrial protein, transcript variant 1 10 ug
$300.00
RC211837L3 Lenti ORF clone of Human SCO cytochrome oxidase deficient homolog 2 (yeast) (SCO2), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged 10 ug
$600.00
RC211837L4 Lenti ORF clone of Human SCO cytochrome oxidase deficient homolog 2 (yeast) (SCO2), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged 10 ug
$600.00
RG211837 SCO2 (tGFP-tagged) - Human SCO cytochrome oxidase deficient homolog 2 (yeast) (SCO2), nuclear gene encoding mitochondrial protein, transcript variant 1 10 ug
$489.00 $500.00

file-alt Citations

SCO2 induces p53-mediated apoptosis by Thr845 phosphorylation of ASK-1 and dissociation of the ASK-1-Trx complex
Madan, Gogna, Kuppusamy et al
Mol. Cell. Biol. (2013) 33 (7), 1285-302 DOI: 10.1128/MCB.06798-11
Cited by 2
AI Summary: OriGene products, specifically p53 cDNA, SCO2 cDNA, p53 siRNA, and SCO2 siRNA, were used in this study to manipulate gene expression and investigate the roles of p53 and SCO2 in apoptosis and tumor regression.
Snippet: DMEM, penicillin, streptomycin, FBS, trypsin-EDTA, and other chemicals of culture grade were purchased from Gibco Life Sciences (India ... Transfections.p53 cDNA, SCO2 cDNA, p53 small interfering RNA (siRNA), and SCO2 siRNA were purchased from Origene (18, 19, 21,–,25
Showing 1-1 of 1 papers.
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