MACROH2A1 (NM_004893) Human Untagged Clone
$457.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | MACROH2A1 |
| Synonyms | H2A.y; H2A/y; H2AF12M; H2AFY; MACROH2A1.1; macroH2A1.2; mH2A1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_004893 |
| Insert Size | 2100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_004893.2, NP_004884.1 |
| RefSeq Size | 1923 bp |
| RefSeq ORF | 1116 bp |
| Locus ID | 9555 |
| UniProt ID | O75367 |
| Cytogenetics | 5q31.1 |
| Domains | A1pp, H2A, histone |
| Protein Pathways | Systemic lupus erythematosus |
| Summary | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Oct 2015 Transcript Variant: This variant (2) has a unique 5' UTR and uses an alternate splice site in its coding region, compared to variant 3. This results in a protein (isoform 2) that is a single amino acid shorter than isoform 3. Variants 2 and 4 encode the same isoform (2). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_004893" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC210576 | H2AFY (Myc-DDK-tagged)-Human H2A histone family, member Y (H2AFY), transcript variant 2 | 10 ug |
$457.00
|
|
| RC210576L3 | Lenti ORF clone of Human H2A histone family, member Y (H2AFY), transcript variant 2, Myc-DDK-tagged | 10 ug |
$757.00
|
|
| RC210576L4 | Lenti ORF clone of Human H2A histone family, member Y (H2AFY), transcript variant 2, mGFP tagged | 10 ug |
$757.00
|
|
| RG210576 | H2AFY (tGFP-tagged) - Human H2A histone family, member Y (H2AFY), transcript variant 2 | 10 ug |
$489.00
$657.00
|
|
Citations
Inhibition of osteosarcoma cell progression by MacroH2A via the downregulation of cyclin D and cyclin‑dependent kinase genes
Yang, Yin, Zhong et al
Mol Med Rep (2014)
Yang, Yin, Zhong et al
Mol Med Rep (2014)
Cited by 7
AI Summary: OriGene contributed to this study by providing the MacroH2A open reading frame fragment (product: SC110068), which was used to construct the MacroH2A recombinant expression plasmid for investigating its effects on osteosarcoma cell progression.
Snippet: (Dallas, TX, USA;sc‑62576‑SH), and the MacroH2A recombinant expression plasmid was produced in‑house as follows: the open reading frame fragment was obtained from OriGene Technologies (SC110068;Rockville, MD, USA) and cloned into the plasmid between ... Cite SaveSaving
Showing 1-1 of 1 papers.
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