S100A4 (NM_019554) Human Untagged Clone
$150.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | S100A4 |
| Synonyms | 18A2; 42A; CAPL; FSP1; MTS1; P9KA; PEL98 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_019554 |
| Insert Size | 540 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_019554.1, NP_062427.1 |
| RefSeq Size | 507 bp |
| RefSeq ORF | 306 bp |
| Locus ID | 6275 |
| UniProt ID | P26447 |
| Cytogenetics | 1q21.3 |
| Domains | EFh, S_100 |
| Summary | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. provided by RefSeq, Jul 2008 Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same isoform. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_019554" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC201616 | S100A4 (Myc-DDK-tagged)-Human S100 calcium binding protein A4 (S100A4), transcript variant 2 | 10 ug |
$150.00
|
|
| RC201616L1 | Lenti ORF clone of Human S100 calcium binding protein A4 (S100A4), transcript variant 2, Myc-DDK-tagged | 10 ug |
$450.00
|
|
| RC201616L2 | Lenti ORF clone of Human S100 calcium binding protein A4 (S100A4), transcript variant 2, mGFP tagged | 10 ug |
$450.00
|
|
| RC201616L3 | Lenti ORF clone of Human S100 calcium binding protein A4 (S100A4), transcript variant 2, Myc-DDK-tagged | 10 ug |
$450.00
|
|
| RC201616L4 | Lenti ORF clone of Human S100 calcium binding protein A4 (S100A4), transcript variant 2, mGFP tagged | 10 ug |
$450.00
|
|
| RG201616 | S100A4 (tGFP-tagged) - Human S100 calcium binding protein A4 (S100A4), transcript variant 2 | 10 ug |
$489.00
|
|
Citations
S100A4 is activated by RhoA and catalyzes the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle
Zhang, Gunst
J. Physiol. (Lond.) (2020)
Zhang, Gunst
J. Physiol. (Lond.) (2020)
AI Summary: OriGene products, including the S100A4 shRNA plasmid (Cat# TG309668), RhoA shRNA plasmid (Cat# TG309823), and pCMV6-XL4 human untagged S100A4 (Cat# SC109749), were used in this study to manipulate the expression of S100A4 and RhoA, enabling the authors to investigate their roles in non-muscle myosin polymerization and airway smooth muscle contraction.
S100A4 is secreted by airway smooth muscle tissues and activates inflammatory signaling pathways via Receptors for Advanced Glycation End products (RAGE)
Wu, Zhang, Gunst
Am. J. Physiol. Lung Cell Mol. Physiol. (2020)
Wu, Zhang, Gunst
Am. J. Physiol. Lung Cell Mol. Physiol. (2020)
Cited by 22
AI Summary: In this study, the OriGene product pCMV6-XL4 human untagged S100A4 (Cat# SC109749) was used to express S100A4, enabling the investigation of its role in airway smooth muscle inflammation and signaling via the RAGE receptor.
Snippet: encoding human RAGE, pcDNA3-RAGE (Addgene plasmid #71435) and pcDNA3-- 106 RAGEΔcyto (Addgene plasmid #71436) (20);pCMV6-XL4 human untagged S100A4 (# 107 SC109749, Origene);RAGE Antagonist, FPS-ZM1, from Sigma-Aldrich (Cat. # 553030;- encoding human RAGE, pcDNA3-RAGE (Addgene plasmid #71435) and pcDNA3-- 106 RAGEΔcyto (Addgene plasmid #71436) (20)
Showing 1-2 of 2 papers.
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