FGFR1 (NM_023106) Human Untagged Clone
SKU
SC109228
FGFR1 (untagged)-Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 4
$670.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | FGFR1 |
| Synonyms | bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | NotI-NotI | |
| ACCN | NM_023106 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_023106.1, NP_075594.1 |
| RefSeq Size | 3786 bp |
| RefSeq ORF | 2196 bp |
| Locus ID | 2260 |
| UniProt ID | P11362 |
| Cytogenetics | 8p11.23 |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Adherens junction, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
| Summary | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. provided by RefSeq, Jul 2008 Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses a different in-frame splice junction compared to variant 1. This variant encodes isoform 4, also known as isoform I, H3, and the 2-Ig Domain form, which is 91 aa shorter than isoform 1. |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_023106" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC220009 | FGFR1 (Myc-DDK-tagged)-Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 4 | 10 ug |
$669.00
|
|
| RC220009L1 | Lenti ORF clone of Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 4, Myc-DDK-tagged | 10 ug |
$969.00
|
|
| RC220009L2 | Lenti ORF clone of Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 4, mGFP tagged | 10 ug |
$969.00
|
|
| RC220009L3 | Lenti ORF clone of Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 4, Myc-DDK-tagged | 10 ug |
$969.00
|
|
| RC220009L4 | Lenti ORF clone of Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 4, mGFP tagged | 10 ug |
$969.00
|
|
| RG220009 | FGFR1 (tGFP-tagged) - Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 4 | 10 ug |
$869.00
|
|
| SC323593 | FGFR1 (untagged)-Kinase deficient mutant (K512M) of Human fibroblast growth factor receptor 1 (FGFR1), transcript variant 4 | 10 ug |
$670.00
|
|
Citations
EGFR mediates responses to small molecule drugs targeting oncogenic fusion kinases
Vaishnavi, Schubert, Rix et al
Cancer Res. (2017)
Vaishnavi, Schubert, Rix et al
Cancer Res. (2017)
BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells
Lavery, Swain, Falb et al
J Biol Chem (2008) 283 (30), 20948-58 DOI: 10.1074/jbc.M800850200
Lavery, Swain, Falb et al
J Biol Chem (2008) 283 (30), 20948-58 DOI: 10.1074/jbc.M800850200
AI Summary: OriGene products, specifically siRNAs targeting ACVR1A, BMPR1A, ACVR2A, BMPR2, BMPR1B, and ACVR2B, were used in this study to knock down individual BMP receptors and elucidate their distinct roles in BMP-induced osteoblastic differentiation of human mesenchymal stem cells.
Showing 1-2 of 2 papers.
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