BMPR2 (NM_001204) Human Untagged Clone

SKU SC108987

BMPR2 (untagged)-Human bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2)

Product Data

• Type: Human Untagged Clone
• Target Symbol: BMPR2
• Synonyms: BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_001204 edited; ATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTG; GTCAGCGCTGCGGCTGCTTCGCAGAATCAAGAACGGCTATGTGCGTTTAAAGATCCGTAT; CAGCAAGACCTTGGGATAGGTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGC; TCGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACATAAATCTTGTA; AAACAAGGATGTTGGTCTCACATTGGAGATCCCCAAGAGTGTCACTATGAAGAATGTGTA; GTAACTACCACTCCTCCCTCAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACA; GATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAACACCACTCAGT; CCACCTCATTCATTTAACCGAGATGAGACAATAATCATTGCTTTGGCATCAGTCTCTGTA; TTAGCTGTTTTGATAGTTGCCTTATGCTTTGGATACAGAATGTTGACAGGAGACCGTAAA; CAAGGTCTTCACAGTATGAACATGATGGAGGCAGCAGCATCCGAACCCTCTCTTGATCTA; GATAATCTGAAACTGTTGGAGCTGATTGGCCGAGGTCGATATGGAGCAGTATATAAAGGC; TCCTTGGATGAGCGTCCAGTTGCTGTAAAAGTGTTTTCCTTTGCAAACCGTCAGAATTTT; ATCAACGAAAAGAACATTTACAGAGTGCCTTTGATGGAACATGACAACATTGCCCGCTTT; ATAGTTGGAGATGAGAGAGTCACTGCAGATGGACGCATGGAATATTTGCTTGTGATGGAG; TACTATCCCAATGGATCTTTATGCAAGTATTTAAGTCTCCACACAAGTGACTGGGTAAGC; TCTTGCCGTCTTGCTCATTCTGTTACTAGAGGACTGGCTTATCTTCACACAGAATTACCA; CGAGGAGATCATTATAAACCTGCAATTTCCCATCGAGATTTAAACAGCAGAAATGTCCTA; GTGAAAAATGATGGAACCTGTGTTATTAGTGACTTTGGACTGTCCATGAGGCTGACTGGA; AATAGACTGGTGCGCCCAGGGGAGGAAGATAATGCAGCCATAAGCGAGGTTGGCACTATC; AGATATATGGCACCAGAAGTGCTAGAAGGAGCTGTGAACTTGAGGGACTGTGAATCAGCT; TTGAAACAAGTAGACATGTATGCTCTTGGACTAATCTATTGGGAGATATTTATGAGATGT; ACAGACCTCTTCCCAGGGGAATCCGTACCAGAGTACCAGATGGCTTTTCAGACAGAGGTT; GGAAACCATCCCACTTTTGAGGATATGCAGGTTCTCGTGTCTAGGGAAAAACAGAGACCC; AAGTTCCCAGAAGCCTGGAAAGAAAATAGCCTGGCAGTGAGGTCACTCAAGGAGACAATC; GAAGACTGTTGGGACCAGGATGCAGAGGCTCGGCTTACTGCACAGTGTGCTGAGGAAAGG; ATGGCTGAACTTATGATGATTTGGGAAAGAAACAAATCTGTGAGCCCAACAGTCAATCCA; ATGTCTACTGCTATGCAGAATGAACGCAACCTGTCACATAATAGGCGTGTGCCAAAAATT; GGTCCTTATCCAGATTATTCTTCCTCCTCATACATTGAAGACTCTATCCATCATACTGAC; AGCATCGTGAAGAATATTTCCTCTGAGCATTCTATGTCCAGCACACCTTTGACTATAGGG; GAAAAAAACCGAAATTCAATTAACTATGAACGACAGCAAGCACAAGCTCGAATCCCCAGC; CCTGAAACAAGTGTCACCAGCCTCTCCACCAACACAACAACCACAAACACCACAGGACTC; ACGCCAAGTACTGGCATGACTACTATATCTGAGATGCCATACCCAGATGAAACAAATCTG; CATACCACAAATGTTGCACAGTCAATTGGGCCAACCCCTGTCTGCTTACAGCTGACAGAA; GAAGACTTGGAAACCAACAAGCTAGACCCAAAAGAAGTTGATAAGAACCTCAAGGAAAGC; TCTGATGAGAATCTCATGGAGCACTCTCTTAAACAGTTCAGTGGCCCAGACCCACTGAGC; AGTACTAGTTCTAGCTTGCTTTACCCACTCATAAAACTTGCAGTAGAAGCAACTGGACAG; CAGGACTTCACACAGACTGCAAATGGCCAAGCATGTTTGATTCCTGATGTTCTGCCTACT; CAGATCTATCCTCTCCCCAAGCAGCAGAACCTTCCCAAGAGACCTACTAGTTTGCCTTTG; AACACCAAAAATTCAACAAAAGAGCCCCGGCTAAAATTTGGCAGCAAGCACAAATCAAAC; TTGAAACAAGTCGAAACTGGAGTTGCCAAGATGAATACAATCAATGCAGCAGAACCTCAT; GTGGTGACAGTCACCATGAATGGTGTGGCAGGTAGAAACCACAGTGTTAACTCCCATGCT; GCCACAACCCAATATGCCAATGGGACAGTACTATCTGGCCAAACAACCAACATAGTGACA; CATAGGGCCCAAGAAATGTTGCAGAATCAGTTTATTGGTGAGGACACCCGGCTGAATATT; AATTCCAGTCCTGATGAGCATGAGCCTTTACTGAGACGAGAGCAACAAGCTGGCCATGAT; GAAGGTGTTCTGGATCGTCTTGTGGACAGGAGGGAACGGCCACTAGAAGGTGGCCGAACT; AATTCCAATAACAACAACAGCAATCCATGTTCAGAACAAGATGTTCTTGCACAGGGTGTT; CCAAGCACAGCAGCAGATCCTGGGCCATCAAAGCCCAGAAGAGCACAGAGGCCTAATTCT; CTGGATCTTTCAGCCACAAATGTCCTGGATGGCAGCAGTATACAGATAGGTGAGTCAACA; CAAGATGGCAAATCAGGATCAGGTGAAAAGATCAAGAAACGTGTGAAAACTCCCTATTCT; CTTAAGCGGTGGCGCCCCTCCACCTGGGTCATCTCCACTGAATCGCTGGACTGTGAAGTC; AACAATAATGGCAGTAACAGGGCAGTTCATTCCAAATCCAGCACTGCTGTTTACCTTGCA; GAAGGAGGCACTGCTACAACCATGGTGTCTAAAGATATAGGAATGAACTGTCTGTGA;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001204 unedited; CCAATTCCCTCGAGGGTGAAGGAAGTCCCGAAGCGAAACTTAAGGAATCCTGCCTTCCCG; GAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCCGGCTTCGTCC; TTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGATANCCTTG; CTCTCCGCACCCTGGATATGTTTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAAC; TACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCACAGACATGCC; TTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGG; AGAGAAATGAAGGGAATTTCTGCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCA; GCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGGGAGAGAAGA; CGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCT; GATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGC; TACCATGGACCATCCTGCTGGTCAGCGCTGCGGCTGCTTCGCAGAATCAAGAACGGCTAT; GTGCGTTTAAAGATCCGTATCAGCAAGACCCTTGGATAGGTGAGAGTAGAATCTCTCATN; GAAATGGGACAATATTATGCTCGAAAGGTAGCACCTGCTATGGGCCTTGGGAGAAATCAA; AAGGGACATAAATCTTGTAAACAGGGATGTTGGTCTCACATTTGGAGATCCCAAGAGTGT; CCCTTTGAAAATGTGTAGTAACTACCCT;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001204 unedited; NTCCCCCCCCCCGGTCCNCCGCCGCCCCCCTCCCCCNCCNNTCCTCCGCCTCTGCTCCGC; GGCCCGGCATCTAGCATCGAGTTTTTTTTTTTTTTTTTTAAACATCTTCTGCATGTTTAA; ATGATGCAAAAAAAATTTCACTCCATAGGCTTGAAAACATTTCACAGACAGTTCATTCCT; ATATCTTTAGACACCATGGTTGTAGCAGTGCCTCCTTCTGCAAGGTAAACAGCAGCGCTG; GATTTGGAATGAACTGCCCTGTTACTGCCATTATTGTTGACTTCACAGTCCAGCGATTCA; GTGGAGATGACCCAGGTGGAGGGGCGCCACCGCTTAAGAGAATAGGGAGTTTTCACACGT; TTCTTGATCTTTTCACCTGATCCTGATTTGCCATCTTGTGTTGACTCACCTATCTGTATA; CTGCTGCCATCCAGGACATTTGTGGCTGAAAGATCCAGAGAATTAGGCCTCTGTGCTCTT; CTGGGCTTTGATGGCCCAGGATCTGCTGCTGTGCTTGGAACACCCTGTGCAAGAACATCT; TGCCCTGAACATGGATTGCTGTTGTTGTTATTGGAATTAGTTCGGCCACCTTCTAGTTGG; CCGCTCCCTCCTGTCCACAAGACGATCCAGAACACCTTCATCATGGCCAGNTTGNTGCTC; TCGTCTCAGTAAAGGCTCATGCTCATCAGGACTGTGATTCATACTCACCCCGTGTGTCCT; TACCAATAAACTGATTCTCGAACATTTCTTGGCCCTTATGTGTCACTATGTTCGGTGCTT; GGCCAGACACTACCGGCCCATTGCACATTGGGTTCGGGCCCATGGCACTTACCACTGTGG; CTTCTACCTGCCACACCATCCTGGGGACTGCCACACAAGAGGCTTTGTGCATTGATTGGT; TTTATTTGGGCACCTCAGTTCCACTTGTTTAAGGTT;
• Restriction Sites: NotI-NotI
• ACCN: NM_001204
• Insert Size: 3670 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.; ; The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001204.5, NP_001195.2
• RefSeq Size: 11449 bp
• RefSeq ORF: 3117 bp
• Locus ID: 659
• UniProt ID: Q13873
• Cytogenetics: 2q33.1-q33.2
• Domains: Activin_recp, pkinase, S_TKc, TyrKc
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
• Summary: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020]; Transcript Variant: This variant (1) encodes the full length isoform. Isoform 1 is 508 aa longer than isoform 2 and includes a long cytoplasmic tail unique to this bone morphogenetic protein type II receptor.