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PHLPP (PHLPP1) (NM_194449) Human Untagged Clone

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SKU
SC108817
PHLPP1 (untagged)-Human PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1)
  $1,050.00
In Stock*
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Specifications
Specifications
Product Data
Type Human Untagged Clone
Target Symbol PHLPP
Synonyms PHLPP; PLEKHE1; PPM3A; SCOP
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
Fully Sequenced ORF
>NCBI ORF sequence for NM_194449, the custom clone sequence may differ by one or more nucleotides


ATGGAGCCCGCCGCCGCGGCCACGGTACAGCGACTCCCCGAGCTCGGCAGGGAGGACCGAGCTTCGGCTC
CGGCGGCCGCCGCTGCGGCAGCAGCAGCAGCAGCGGCGGCCGCGGCGGCTCTGGCGGCGGCGGCCGGGGG
CGGCCGGAGTCCGGAGCCCGCGCTGACCCCGGCGGCCCCGAGCGGCGGGAACGGCAGCGGCAGCGGGGCG
CGGGAAGAGGCCCCAGGCGAGGCGCCGCCGGGGCCGCTGCCGGGCAGAGCGGGGGGTGCCGGGCGCAGGA
GGCGGCGCGGGGCGCCCCAGCCCATTGCCGGCGGGGCTGCCCCCGTACCCGGGGCCGGCGGCGGCGCCAA
CTCCCTCCTGCTGAGGAGAGGGCGGCTGAAGAGGAATCTGTCCGCGGCCGCCGCGGCCGCCTCCTCGTCG
TCGTCGTCCTCGGCCGCTGCTGCCTCGCACTCCCCCGGCGCTGCCGGCCTCCCCGCCTCCTGCTCGGCCT
CGGCGTCGCTGTGCACCCGGAGCCTGGACAGGAAGACGCTGCTTCTGAAGCACCGGCAGACGCTGCAGCT
GCAGCCGTCGGACCGGGACTGGGTGAGGCACCAGCTCCAGCGCGGCTGCGTGCACGTCTTCGACCGCCAC
ATGGCCTCGACCTACCTGCGCCCGGTGCTCTGCACACTGGACACCACGGCCGGCGAGGTGGCCGCCCGCC
TGCTGCAGCTGGGCCACAAAGGCGGCGGCGTGGTGAAGGTGCTGGGCCAGGGGCCCGGAGCCGCCGCCGC
CCGGGAGCCCGCTGAACCGCCCCCCGAGGCCGGCCCCCGGCTGGCGCCCCCGGAGCCGCGGGACTCGGAG
GTACCGCCCGCGAGGAGCGCGCCGGGTGCCTTCGGGGGGCCTCCGCGCGCGCCCCCCGCCGACCTACCCC
TGCCCGTCGGCGGCCCGGGCGGGTGGTCGCGCCGCGCCAGCCCAGCGCCCTCGGACTCCAGCCCCGGCGA
GCCGTTCGTTGGGGGCCCTGTCTCTTCGCCCCGCGCCCCACGGCCTGTGGTCTCCGACACCGAGAGCTTC
AGTCTGAGTCCCAGCGCCGAGAGCGTGTCTGACCGGTTGGACCCCTACAGCAGCGGCGGCGGCTCCTCGT
CGTCGTCGGAAGAGCTCGAGGCCGACGCAGCCTCGGCCCCGACGGGGGTCCCGGGCCAGCCCCGCCGTCC
CGGCCACCCCGCGCAGCCCCTCCCGCTTCCCCAGACGGCTTCCTCGCCTCAGCCGCAGCAGAAAGCCCCG
AGGGCCATTGACAGCCCGGGCGGGGCCGTCCGCGAGGGGTCGTGCGAGGAGAAGGCAGCGGCAGCCGTGG
CCCCGGGAGGCCTCCAGTCTACCCCCGGGAGGAGCGGGGTGACCGCGGAGAAGGCGCCTCCGCCGCCCCC
GCCGCCCACCCTGTACGTGCAGCTCCACGGAGAGACCACCCGGCGCTTGGAGGCGGAGGAGAAGCCATTG
CAGATCCAAAATGACTACCTCTTCCAACTGGGATTTGGGGAGCTGTGGAGGGTGCAGGAGGAAGGCATGG
ACTCGGAGATTGGCTGCCTCATCCGCTTCTATGCAGGAAAACCTCACAGCACGGGTAGCTCTGAACGGAT
TCAGCTCTCAGGAATGTATAATGTCCGTAAAGGCAAGATGCAGTTGCCAGTGAACCGATGGACAAGACGC
CAAGTCATCCTATGTGGGACCTGCCTGATAGTATCATCTGTGAAAGACAGCTTGACCGGAAAGATGCATG
TTCTGCCACTAATTGGTGGAAAAGTAGAAGAAGTGAAAAAGCACCAACACTGTTTAGCATTTAGCTCCTC
TGGACCCCAAAGCCAGACTTACTACATTTGCTTTGATACTTTCACAGAATACTTAAGGTGGCTGCGACAA
GTCTCCAAGGTTGCATCCCAGCGCATTAGCTCAGTGGACCTCTCGTGTTGTAGCCTGGAACATCTGCCTG
CCAACCTCTTCTACAGCCAAGACCTCACTCATCTCAATTTAAAACAAAACTTCCTAAGGCAGAACCCTAG
CCTTCCAGCTGCCAGGGGGCTTAATGAACTGCAAAGGTTCACCAAGTTGAAGAGTCTTAACCTTTCCAAT
AATCATTTAGGGGACTTCCCACTGGCAGTCTGCAGTATTCCAACCCTGGCAGAGCTGAACGTGTCCTGCA
ATGCCCTGCGATCAGTCCCGGCAGCCGTTGGAGTGATGCACAACTTACAGACATTTTTGTTGGATGGAAA
CTTTCTCCAATCCCTTCCTGCTGAGTTGGAGAACATGAAGCAGCTTAGTTATCTGGGTCTTTCTTTCAAT
GAATTTACTGACATTCCCGAAGTATTGGAGAAATTGACTGCTGTGGATAAACTTTGTATGTCTGGAAACT
GTGTGGAGACCCTTAGGCTACAGGCTTTAAGAAAAATGCCTCACATTAAACATGTGGATCTAAGGTTGAA
CGTAATTAGGAAGCTGATAGCAGATGAAGTGGACTTTCTACAGCATGTTACTCAGCTTGACCTACGAGAC
AATAAGCTTGGTGATCTAGATGCTATGATTTTCAACAACATTGAAGTTTTACACTGTGAAAGGAATCAAC
TGGTCACATTAGACATCTGTGGCTATTTCCTAAAAGCGCTCTATGCCTCTTCTAATGAACTTGTTCAACT
TGATGTTTACCCAGTTCCAAATTATCTGTCCTACATGGATGTTTCAAGGAACCGCTTAGAAAATGTGCCT
GAGTGGGTATGTGAAAGCCGAAAGCTAGAAGTTTTGGATATTGGCCATAATCAAATATGTGAACTTCCTG
CCCGCTTATTTTGTAATAGCAGTCTCCGGAAACTACTGGCAGGACACAACCAGTTGGCAAGGCTGCCTGA
AAGGCTAGAAAGAACCTCGGTGGAGGTCTTGGATGTGCAACACAACCAGCTCCTTGAGCTCCCACCTAAC
CTTCTGATGAAGGCTGACAGCCTGAGATTCCTGAACGCCTCTGCGAACAAACTGGAAAGCCTTCCTCCAG
CCACGCTTTCCGAAGAGACAAACAGTATCTTACAAGAGTTGTATTTGACAAATAACAGCCTCACAGACAA
ATGTGTGCCCTTGTTAACGGGACACCCCCATTTGAAGATCCTTCACATGGCCTATAACCGACTTCAGAGT
TTTCCAGCAAGTAAAATGGCGAAACTGGAGGAACTTGAAGAAATTGATCTCAGTGGGAATAAGCTGAAAG
CCATCCCAACAACGATCATGAATTGCAGGCGCATGCACACCGTGATTGCTCACTCCAACTGCATCGAGGT
CTTTCCCGAAGTTATGCAGCTCCCAGAGATCAAGTGTGTGGACCTGAGCTGTAATGAGCTAAGTGAAGTC
ACATTACCAGAAAACCTGCCTCCCAAACTGCAGGAGCTAGACCTGACTGGAAACCCGCGCCTTGTCCTTG
ATCACAAAACCCTGGAACTACTGAATAATATCCGCTGTTTCAAGATTGATCAGCCTTCTACAGGAGACGC
TTCCGGAGCCCCAGCTGTATGGAGTCATGGTTACACTGAAGCTTCGGGGGTAAAAAACAAGTTGTGTGTC
GCAGCCCTGTCGGTGAATAACTTCTGTGACAACCGCGAAGCCCTGTATGGTGTGTTTGACGGAGACCGGA
ATGTGGAGGTGCCCTACCTTCTCCAGTGCACTATGAGTGACATTTTGGCTGAAGAGCTGCAAAAAACAAA
AAACGAAGAAGAATACATGGTCAATACATTCATTGTCATGCAAAGGAAACTTGGAACTGCTGGGCAGAAG
CTTGGTGGTGCCGCTGTCCTTTGTCATATCAAGCATGACCCTGTGGATCCAGGAGGATCCTTCACCTTGA
CCTCTGCTAATGTGGGCAAGTGCCAAACAGTTCTCTGTCGAAATGGAAAGCCGCTGCCTCTGTCCAGATC
TTACATCATGAGCTGTGAAGAAGAGCTGAAGAGGATTAAACAGCACAAGGCCATTATCACTGAGGATGGC
AAGGTGAACGGAGTGACTGAGTCCACGCGCATCCTGGGCTACACCTTCCTCCATCCCAGTGTGGTGCCTC
GCCCCCACGTGCAGTCCGTGCTCCTGACTCCCCAGGATGAGTTCTTCATCCTAGGCAGTAAGGGGTTGTG
GGACAGCCTGTCCGTCGAGGAGGCCGTGGAAGCCGTGCGCAACGTGCCCGATGCCCTGGCTGCTGCCAAG
AAGCTGTGTACCCTGGCCCAGAGCTACGGCTGCCACGACAGCATCAGCGCTGTGGTGGTGCAGCTCAGTG
TCACTGAGGACAGCTTCTGCTGCTGCGAGCTCAGCGCCGGTGGGGCTGTGCCACCACCCAGTCCTGGCAT
CTTTCCTCCCTCAGTGAACATGGTGATCAAGGATCGGCCCTCAGATGGGCTGGGCGTGCCGTCCTCCAGC
AGCGGCATGGCTTCCGAGATTAGCAGTGAGCTCTCCACTTCTGAGATGAGCAGCGAGGTGGGGTCAACAG
CCTCCGATGAGCCCCCGCCCGGAGCCCTAAGCGAGAACAGCCCTGCCTACCCCAGTGAGCAGCGCTGCAT
GCTCCACCCCATCTGTCTGTCCAACTCCTTCCAGCGCCAGCTATCCAGCGCCACGTTCTCTAGCGCCTTC
TCCGACAACGGCCTTGACAGTGACGATGAGGAGCCCATCGAGGGCGTCTTCACCAACGGCAGCCGGGTGG
AGGTGGAGGTGGACATCCACTGCAGCCGGGCCAAGGAGAAGGAGAAACAGCAGCACCTGCTTCAGGTGCC
AGCAGAGGCCAGTGATGAGGGCATTGTCATCAGCGCCAACGAGGATGAGCCAGGTCTGCCCAGGAAGGCA
GACTTCTCTGCCGTTGGGACCATTGGGCGCCGGAGGGCCAATGGCTCTGTTGCGCCCCAGGAAAGGAGCC
ACAATGTGATAGAGGTGGCTACAGACGCACCTCTTCGAAAGCCTGGAGGCTATTTTGCTGCCCCGGCTCA
GCCGGATCCTGATGATCAGTTTATCATACCCCCGGAGCTGGAAGAGGAGGTCAAAGAAATCATGAAGCAT
CACCAGGAGCAACAGCAGCAGCAGCAGCCGCCACCACCCCCTCAGCTCCAGCCGCAGCTGCCGCGGCACT
ACCAGCTGGACCAGCTGCCAGATTATTACGACACGCCACTATGA

5' Read Nucleotide Sequence
>OriGene 5' read for NM_194449 unedited
CCGCGTATTCGGCACGAGGGAGGAGCGGGGTGACCGCGGAGAAGCGCCTCCGCCGCCCCC
GCCGCCCACCCTGTACGTGCAGCTCCACGGAGAGACCACCCGGCGCTTGGAGGCGGAGGA
GAAGCCATTGCAGATCCAAAATGACTACCTCTTCCAACTGGGATTTGGGGAGCTGTGGAG
GGTGCAGGAGGAAGGCATGGACTCGGAGATTGGCTGCCTCATCCGCTTCTATGCAGGAAA
ACCTCACAGCACGGGTAGCTCTGAACGGATTCAGCTCTCAGGAATGTATAATGTCCGTAA
AGGCAAGATGCAGTTGCCAGTGAACCGATGGACAAGACGCCAAGTCATCCTATGTGGGAC
CTGCCTGATAGTATCATCTGTGAAAGACAGCTTGACCGGAAAGATGCATGTTCTGCCACT
AATTGGTGGAAAAGTAGAAGAAGTGAAAAAGCACCAACACTGTTTAGCATTTAGCTCCTC
TGGACCCCAAAGCCAGACTTACTACATTTGCTTTGATACTTTCACAGAATACTTAAGGTG
GCTGCGACAAGTCTCCAAGGTTGCATCCCAGCGCATTAGCTCAGTGGACCTCTCGTGTTG
TAGCCTGGAACATCTGCCTGCCAACCTCTTCTACAGCCAAGACCTCACTCATCTCAATTT
AAAACAAAACTTCCTAAGGCAGAACCCTAGCCTTCCAGCTGCCAGGGGGCTTAATGAACT
GCAAGGGTTCACCAAGTGAAGAAGTCTACCCCTTTCCATATCATTTAGGGGACTTCCTCT
GGCAGNCTGCAGTATTCCAACCTGGCAAGCTGAAACGGGTCCTGCAATGCCCTGGGATCA
GTCCCCGCAGCGGTTGGAAGTGATGCACACCTACAAACT
3' Read Nucleotide Sequence
>OriGene 3' read for NM_194449 unedited
NCACCTTGTTTGTTTCTGTTTATTGTAACAAAATTATGACATGTCCATTTGTGCATTCTG
CTTGAGTATAACTCTGGGTATGTAAATGGCCTAATGGGGCACTATACAACCATGCTGATT
GTGGCAGCAGTAAGGAACACAGTTAAAAGTGTCTGTCAAAGTGGGAAGGCTGGGACAGGG
GAGGAAAATGGGTTCAGGGCCCTTGGGTGCAGGTTCTTGTCCAGTGGCCTAAGATCCATT
TCCTCCGGACAGAAACACTGCAGCTGCTCAGCCTCCTCATTCAGTGAAGTGAGGGTGAGT
TGTGAGGCAGGCAGGCTCCTCAAAGGGGAGGGGGAGGGGAAACGTCAGTTACTTGGGCTG
TGTCCTTACGCCAAGACTACAAAACATCGTAAGCCTCACTATACAACACTGAGCTATTTA
CAATGGAAATTCTCAATCAGCTGTTCTCTCAGAGAAAATTAATGAATCCCAGTGACTTAA
GTCACCTGACAAAGTAAAGCAACTCCTAGGAGTTAGTCTCCCCATTCTACGAATGTCTAT
TATTTTCAGGACATCGACCATACAAAACCTAATAAAACTAGCCCCAGGCCTTTTGCTCGC
GAACACACGCCGAATTACGCTACTAGTAAATACTTTAACATCTGCCGACTGGCATGCCTT
GTCAACCAACAGAATAGAGCCTGTTTCAAACATTTTACCCTATTCATTATATAGGAGCCC
TGACCACAACCATACGAATTGGTTCTTTTTTCTCCCCGACCCAGAGTTTTTCCGCGCACC
AATTACATAAGGTCTTATCATCGTCTTAACGAACCACCGGCGCAAAACAGCCGGTTTTTA
TAAACAAAACCACTCACTAAAGAACCTGTTGGTATTTTCACACCAACACACCGCCGCCCA
ATATCGCACCACATCCAATGGGTCACAACACAACCCTCCTTATTGT
Restriction Sites NotI-NotI |
ACCN NM_194449
Insert Size 4500 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_194449.1, NP_919431.1
RefSeq Size 4798 bp
RefSeq ORF 3618 bp
Locus ID 23239
UniProt ID O60346
Cytogenetics 18q21.33
Summary This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. provided by RefSeq, Dec 2011
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"NM_194449" in other vectors (6)
SKU Description Size Price
RC203930 PHLPP1 (Myc-DDK-tagged)-Human PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) 10 ug
$1,049.00
RC203930L1 Lenti ORF clone of Human PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), Myc-DDK-tagged 10 ug
$1,349.00
RC203930L2 Lenti ORF clone of Human PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), mGFP tagged 10 ug
$1,349.00
RC203930L3 Lenti ORF clone of Human PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), Myc-DDK-tagged 10 ug
$1,349.00
RC203930L4 Lenti ORF clone of Human PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1), mGFP tagged 10 ug
$1,349.00
RG203930 PHLPP1 (tGFP-tagged) - Human PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) 10 ug
$789.00 $1,249.00

file-alt Citations

Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells
Suljagic, Laurenti, Tarnani et al
Leukemia (2010) 24 (12), 2063-71 DOI: 10.1038/leu.2010.201
Cited by 29
AI Summary: OriGene products contributed to this study by providing the PHLPP1 cDNA (OriGene, SC119071) used for re-expression experiments in primary CLL B-cells and lymphoma cell lines, enabling the authors to assess the functional impact of PHLPP1 restoration on BCR signaling and cell survival.
Showing 1-1 of 1 papers.
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